Rchr
J-GLOBAL ID:201401015424423713   Update date: Feb. 01, 2024

Toshifumi Hara

ハラ トシフミ | Toshifumi Hara
Research field  (3): Virology ,  Molecular biology ,  Tumor biology
Research keywords  (3): メチル化修飾 ,  RNA ,  metastasis
Research theme for competitive and other funds  (5):
  • 2022 - 2025 スキルス胃癌の悪性化に伴い発現増加するMETTL27の機能解析
  • 2019 - 2022 Analysis of RNA methylation in metastasis of human scirrhous gastric cancer
  • 2017 - 2019 Functional analysis of long non-coding RNAs associated with metastasis of human scirrhous gastric cancers
  • 2015 - 2018 Crosstalk between stress granules and autophagy in protein degradation
  • 2015 - 2017 Identification of miRNAs inducing synthetic lethality in ATL cells
Papers (27):
  • Toshifumi Hara, Yuuki Tominaga, Koji Ueda, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei. Elevated METTL9 is associated with peritoneal dissemination in human scirrhous gastric cancers. Biochemistry and Biophysics Reports. 2022. 30. 101255-101255
  • Toshifumi Hara, Yuri Nomura, Masaaki Hattori, Keichiro Mihara, Kazuyoshi Yanagihara, Yoshifumi Takei. Elevated Expression of CELSR1 is Associated with Peritoneal Metastasis in Human Scirrhous Gastric Cancers. BPB Reports. 2021. 4. 4. 103-111
  • Mariko Mizuguchi, Toshifumi Hara, Manami Yoshita-Takahashi, Takashi Kohda, Yuetsu Tanaka, Masataka Nakamura. Promoter CpG methylation inhibits Krüppel-like factor 2 (KLF2)-Mediated repression of hTERT gene expression in human T-cells. Biochemistry and Biophysics Reports. 2021. 26. 100984-100984
  • Yoshifumi Takei, Toshifumi Hara, Akiko Suzuki, Keichiro Mihara, Kazuyoshi Yanagihara. Long Noncoding RNA HOTAIR Promotes Epithelial-Mesenchymal Transition and Is a Suitable Target to Inhibit Peritoneal Dissemination in Human Scirrhous Gastric Cancers. Pathobiology : journal of immunopathology, molecular and cellular biology. 2020. 1-14
  • Svetlana Piatnitskaia, Masahiko Takahashi, Hiroki Kitaura, Yoshinori Katsuragi, Taichi Kakihana, Lu Zhang, Akiyoshi Kakita, Yuriko Iwakura, Hiroyuki Nawa, Takeshi Miura, et al. USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells. Scientific Reports. 2019. 9. 1
more...
MISC (1):
  • M. Mizuguchi, H. Asao, T. Hara, M. Higuchi, M. Fujii, M. Nakamura. Induction of Interleukin-21 and its Receptor Genes by HTLV-1 Tax. AIDS RESEARCH AND HUMAN RETROVIRUSES. 2009. 25. 11. 1264-1264
Books (2):
  • T-Cell Leukemia
    Intech Open 2011
  • 別冊医学の歩み、サイトカイン : State of arts
    医歯薬出版株式会社 2004
Lectures and oral presentations  (5):
  • The importance of methyltransferase like (METTL) genes on metastatic property in human scirrhous gastric cancer
    (2021)
  • スキルス胃癌の腹膜転移で発現増加するCELSR1の役割
    (第67回日本薬学会東海支部総会大会 2021)
  • 癌転移における新規メチル基転移酵素の機能解析
    (愛知学院大学 医療生命薬学研究所 第8回サイエンスフォーラム 2021)
  • 癌転移を標的とした新しい創薬探索基盤の開発とその実践
    (愛知学院大学 医療生命薬学研究所 第7回サイエンスフォーラム 2019)
  • 癌転移に関わる分子機構の解明とそのアプローチ
    (愛知学院大学薬学部 第96回薬学セミナー 2018)
Education (1):
  • 2003 - 2007 東京医科歯科大学 医歯学総合研究科博士課程
Professional career (1):
  • 博士(医学) (東京医科歯科大学)
Work history (5):
  • 2022/01 - 現在 Aichi Gakuin University School of Pharmacy
  • 2017/01 - 2021/12 Aichi Gakuin University
  • 2014/03 - 2016/12 新潟大学 医歯学総合研究科 助教
  • 2011/08 - 2014/02 National Cancer Institute (NIH) Genetics Branch Visiting Fellow
  • 2007/04 - 2011/07 東京医科歯科大学 医歯学研究支援センター (現: 統合研究機構 研究基盤クラスター リサーチコアセンター ) 助教
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