Research keywords (4):
抗体工学
, モノクローナル抗体
, 抗体創薬
, 腫瘍生物学
Research theme for competitive and other funds (23):
2022 - 2025 膜タンパク質を標的とした先端的がん特異的抗体の開発とその作用機序解明
2022 - 2025 Elucidation of the molecular basis of oral-renal association by periodontal disease exosomes in exacerbation of diabetes and complications of nephropathy
2022 - 2024 The oral-lung axis mediated by exosomes from oral epithelial cells in COVID-19 and the drug discovery
2019 - 2024 難治性がんを標的とした先端的がん特異的抗体創製基盤技術開発とその医療応用
2018 - 2023 Molecular mechanisms and target therapy of vessel co-option and mimicry for glioblastoma
2019 - 2022 糖タンパク質を標的とした革新的がん特異的抗体の開発とその作用機序の解明
2017 - 2022 抗体関連高度開発支援と糖鎖細胞工学による高度化
2019 - 2021 Novel antibody therapy targeting tumor specific sugar-chain modification in tumor cells and cancer associated fibroblasts
2018 - 2021 Study on epidemiological meta-analysis of diabetic nephropathy focusing on complex systems of periodontal disease and intestinal immune disturbance
2017 - 2019 Elucidation of cancer stem cell niche formation mechanisms of CAF derived from oral tissue using Pdpn-cKO mouse
2016 - 2019 脳腫瘍の変異型IDHを標的とした高精度診断法の確立と分子生物学的解析
2014 - 2019 革新的次世代型がん特異的抗体の開発とその臨床応用
2015 - 2018 Elucidation of the pathogenic mechanism of diabetic nephropathy by oral microorganism-derived blood TLR ligand and development for prevention
2012 - 2016 Anti-angiogenic therapy for glioma beyond VEGF inhibition based on tumor microenvironment
2016 - 2016 がん特異的抗体CasMabの開発とその臨床応用
2013 - 2016 変異型イソクエン酸デヒドロゲナーゼの分子生物学的解析とその臨床応用
2012 - 2015 Development of a novel antibody therapy based on antibody-dependent cellular cytotoxicity activity against lung cancer and mesothelioma and identification of the immunological biomarkers
2010 - 2012 CLEC2-PLAG complex-induced oncogenic transformation in the intra-lymphatic microenvironment
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Papers (491):
Miu Hirose, Hiroyuki Suzuki, Rena Ubukata, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato. Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies. Biochemistry and biophysics reports. 2024. 40. 101824-101824
Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Miyuki Yanaka, Guanjie Li, Tomohiro Tanaka, Akira Ohkoshi, Manabu Kawada, Mika Kaneko, et al. Antitumor activities of anti-CD44 monoclonal antibodies in mouse xenograft models of esophageal cancer. Oncology Reports. 2024. 52. 5
Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Guanjie Li, Tomohiro Tanaka, Manabu Kawada, Akira Ohkoshi, Mika K. Kaneko, Yukio Katori, Yukinari Kato. Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas. International Journal of Molecular Sciences. 2024. 25. 17. 9190-9190
Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato. Anti-HER2 Cancer-Specific mAb, H2Mab-250-hG1, Possesses Higher Complement-Dependent Cytotoxicity than Trastuzumab. International journal of molecular sciences. 2024. 25. 15
Rena Ubukata, Hiroyuki Suzuki, Tomohiro Tanaka, Guanjie Li, Mika K Kaneko, Yukinari Kato. Development of Sensitive Anti-Mouse CCR5 Monoclonal Antibodies Using the N-Terminal Peptide Immunization. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2024