Rchr
J-GLOBAL ID:201401017332467520   Update date: Nov. 17, 2024

Shimizu Toshio

シミズ トシオ | Shimizu Toshio
Affiliation and department:
Job title: Professor
Research field  (1): Tumor diagnostics and therapeutics
Research keywords  (3): 第I相試験 ,  新薬開発 ,  臨床腫瘍学
Research theme for competitive and other funds  (3):
  • 2022 - 2025 進行癌に対する次世代抗体薬投与時サイトカインプロファイル緊急網羅的解析モデル探索
  • 2017 - 2019 <領域1-1>がんの最適医療(Precision Medicine)の実現に資するゲノム異常及びバイオマーカーの同定と臨床的有用性の検証 がん薬物療法におけるexceptional responseをもたらす遺伝子異常の研究と治療開発
  • 2012 - 2015 進行非小細胞肺癌を対象としたエルロチニブとYM155の分子標的治療薬併用第I相試験
Papers (94):
  • Noboru Yamamoto, Takafumi Koyama, Jun Sato, Tatsuya Yoshida, Kazuki Sudo, Satoru Iwasa, Shunsuke Kondo, Kan Yonemori, Atsuko Kawasaki, Kyoko Satake, et al. Correction to: Phase I study of the anti-TIGIT antibody tiragolumab in combination with atezolizumab in Japanese patients with advanced or metastatic solid tumors. Cancer chemotherapy and pharmacology. 2024. 94. 3. 491-491
  • Pierre Peterlin, Esma Saada-Bouzid, Mor Moskovitz, Arnaud Pigneux, Junichiro Yuda, Mahipal Sinnollareddy, William R Henner, Diana Chen, Kevin J Freise, Rachel S Leibman, et al. First-in-human clinical trial results with ABBV-184, a first-in-class T-cell receptor/anti-CD3 bispecific protein, in adults with previously treated AML or NSCLC. Expert review of anticancer therapy. 2024. 24. 9. 893-904
  • Takafumi Koyama, Kan Yonemori, Toshio Shimizu, Jun Sato, Shunsuke Kondo, Kazuki Sudo, Tatsuya Yoshida, Yuki Katsuya, Tatsuki Imaizumi, Masashi Enomoto, et al. Phase I Study of Simlukafusp Alfa (FAP-IL2v) with or without Atezolizumab in Japanese Patients with Advanced Solid Tumors. Cancer research communications. 2024. 4. 9. 2349-2358
  • Toshiaki Takakura, Hiroaki Akamatsu, Atsushi Washioka, Eriko Murakami, Ryota Shibaki, Toshio Shimizu, Yasuhiro Koh, Nobuyuki Yamamoto. Unsuccessful rechallenge with nivolumab in a patient with advanced non-small cell lung cancer who had a 6-year complete response and treatment-free period: Case report. Respirology case reports. 2024. 12. 9. e01401
  • Toshiaki Takakura, Toshio Shimizu, Nobuyuki Yamamoto. Antibody-drug conjugates in solid tumors; new strategy for cancer therapy. Japanese journal of clinical oncology. 2024. 54. 8. 837-846
more...
MISC (118):
  • 武田 真幸, 中川 和彦, 林 秀敏, 岩朝 勤, 川上 尚人, 渡邉 諭美, 山本 昇, 米盛 勧, 小山 隆文, 佐藤 潤, et al. ベンダムスチン塩酸塩経口剤(SyB C-0501)の進行性固形がん患者に対する第1相臨床試験. 日本癌治療学会学術集会抄録集. 2021. 59回. O13-5
  • 清水 俊雄. アジア圏における早期新薬開発共通標準化は可能なのか?. 腫瘍内科. 2021. 27. 6. 738-742
  • 古川孝広, BARDIA Aditya, 清水俊雄, TOLCHER Anthony, SPIRA Alexander, 向原徹, LISBERG Aaron E., KROP Ian, PAPADOPOULOS Kyriakos P., HAMILTON Erika, et al. Datopotamab deruxtecanの第1相臨床試験TNBC中間結果. 日本癌治療学会学術集会(Web). 2021. 59th
  • 小山 隆文, 清水 俊雄, 米盛 勧, 小島 勇貴, 松井 直子, 大熊 ひとみ, 野口 瑛美, 須藤 一起, 平川 晃弘, 沖田 南都子, et al. MDM2阻害剤を用いた内膜肉腫対象医師主導治験. 日本心臓血管外科学会学術総会抄録集. 2020. 50回. P23-3
  • 小山 隆文, 清水 俊雄, 米盛 勧, 小島 勇貴, 松井 直子, 大熊 ひとみ, 野口 瑛美, 須藤 一起, 平川 晃弘, 沖田 南都子, et al. MDM2阻害剤を用いた内膜肉腫対象医師主導治験. 日本心臓血管外科学会学術総会抄録集. 2020. 50回. P23-3
more...
Books (8):
  • がん分子標的治療 2014年6月号(Vol.12 No.2)
    メディカルレビュー社 2014
  • 腫瘍内科 第13巻第6号(2014年6月発行)
    科学評論社 2014
  • 日本臨床 最新がん薬物療法学
    日本臨床社 2014
  • 腫瘍内科 第13巻第1号(2014年1月発行)
    科学評論社 2014
  • 腫瘍内科 第9巻第5号(2012年5月発行)
    科学評論社 2012
more...
Lectures and oral presentations  (31):
  • A first-in-Asian phase I dose escalation study to evaluate the safety and pharmacokinetics of VS-6063 (defactinib), a focal adhesion kinase inhibitor in subjects with non-hematologic malignancies
    (The 73rd Annual Meeting of the Japanese Cancer Association (JCA) 2014)
  • Phase I study of YM155, selective survivin suppressant plus elrotnib in patients with EGFR-mutant advanced non-small-cell lung cancer (NSCLC)
    (The 12th Annual Meeting of Japanese Society of Medical Oncology 2014)
  • 日本における早期探索臨床試験の推進について ~海外ベンチャー製薬企業主導型新薬第I相試験実施
    (第22回日本乳癌学会学術集会 JBCS/JSMO Joint Symposium 2014)
  • Completed Phase I Trial of TLC388
    (The 3rd Japan-Taiwan Phase I Oncology Conference (JTOPIC), Taipei, Taiwan 2014)
  • Infrastructural capability of investigator-initiated trials involving unapproved investigational drugs in Japan
    (The 11th Annual Meeting of Japanese Society of Medical Oncology 2013)
more...
Education (2):
  • 2003 - 2007 Kinki University Graduate School Medical Oncology
  • 1993 - 1999 Kinki University Faculty of Medicine Faculty of Medicine
Professional career (1):
  • 博士(医学) (近畿大学)
Work history (8):
  • 2024/11 - 現在 Kansai Medical University Department of New Experimental Therapeutics Professor
  • 2022/04 - 2024/10 Wakayama Medical University Associate Professor
  • 2016/04 - 2022/03 National Cancer Center Hospital of Japan Department of Experimental Therapeutics Head of Physician (Early Phase 1 Drug Development Service)
  • 2012/04 - 2016/03 Kindai University Faculty of Medicine Department of Medical Oncology Associate Professor
  • 2010/01 - 2012/03 START (South Texas Accelerated Research Therapeutics) Phase I Center Clinical Fellow
Show all
Committee career (5):
  • 2022/04 - 現在 ESMO Targeted Anticancer Therapies (TAT) Phase 1 Scientific Committee
  • 2020/04 - 現在 Asia Pacific Oncology Drug Development Consortium (APODDC) Executive Committee
  • 2017/04 - 現在 The Consortium on Harmonization of Institutional Requirements for Clinical Research (CHAIR) Joint Scientific Committee Review Member for Phase 1 trials in Hong Kong, HKSAR IRB Member / Joint Scientific Committee Review Member for Phase 1 trials in Hong Kong, HKSAR
  • 2013/04 - 現在 日本臨床腫瘍学会 学術企画委員
  • 2012/04 - 現在 日本臨床腫瘍学会 協議員
Awards (2):
  • 2019/10 - Chinese Society of Clinical Oncology (CSCO) CSCO 2019 Travel Grant Award 受賞
  • 2011/06 - ASCO ASCO 2011 Merit Award The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in first-in-human phase 1 study
Association Membership(s) (8):
日本製薬医学会 ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  THE JAPAN LUNG CANCER SOCIETY ,  JSMO(日本臨床腫瘍学会) ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  ASCO(American Society of Clinical Oncology) ,  ESMO (European Society of Medical Oncology) ,  AACR (American Association of Cancer Research)
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