Rchr
J-GLOBAL ID：201401018168107794   Update date: Jun. 12, 2024

Tominaga Kaoru

トミナガ カオル | Tominaga Kaoru
Affiliation and department：
Jichi Medical University School of Medicine

About Jichi Medical University School of Medicine


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/20265242.ja.html
Research field  (9)： Nutrition and health science ,  Functional biochemistry ,  Neuroscience - general ,  Molecular biology ,  Genomics ,  Laboratory animal science ,  Tumor biology ,  Cell biology ,  Medical biochemistry
Research keywords  (22)： mitochondria ,  senescence ,  metabolism ,  Epigenetics ,  cancer ,  aging ,  histone modification ,  stem cell ,  chromatin ,  cellular senescence ,  リポ多糖 ,  C3H ,  MAPキナーゼ ,  IL-6 ,  マクロファージ ,  HeJマウス ,  線維芽細胞 ,  NF-κB ,  感染防御 ,  スカベンジャー受容体 ,  LPS(リポ多糖) ,  ノックアウトマウス
Research theme for competitive and other funds  (6)：
  • 2021 - 2024 Investigation of chromatin regulation network for fate decision of neural stem cells and establishment of functional brain structure
  • 2017 - 2021 The role of epigenetic regulator in neural stem cell maintenance and differentiation
  • 2012 - 2016 Mechanism of neural stem cell maintenance by chromatin regulator
  • 1996 - 1996 THE ROLE OF SCAVENGER RECEPTORS ON MURINE MACROPHAGES AGAINST INFECTION
  • 1996 - 1996 リポ多糖(LPS)によるマウスマクロファージ及び線維芽細胞の活性比に関する研究
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Papers (58)：
  • Hirofumi Nakano, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Takashi Ikeda, Shin-Ichiro Kawaguchi, Kiyomi Mashima, Kento Umino, Kaoru Morita, et al. Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease. ImmunoHorizons. 2024. 8. 3. 228-241
  • Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo. Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells. International Journal of Molecular Sciences. 2023. 24. 3. 2113-2113
  • Kiyomi Mashima, Kazuya Sato, Takashi Ikeda, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Shin-Ichiro Kawaguchi, Hirofumi Nakano, Takashi Nagayama, Kento Umino, et al. Dimethyl fumarate ameliorates graft-versus-host disease by inhibiting T-cell metabolism and immune responses through a reactive oxygen species-dependent mechanism. British Journal of Haematology. 2022
  • Rintaro Kuroda, Kaoru Tominaga, Katsumi Kasashima, Kenji Kuroiwa, Eiji Sakashita, Hiroko Hayakawa, Tom Kouki, Nobuhiko Ohno, Kensuke Kawai, Hitoshi Endo. Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo. PLOS ONE. 2021. 16. 7. e0255355-e0255355
  • Yasufumi Kawasaki, Kazuya Sato, Kiyomi Mashima, Hirofumi Nakano, Takashi Ikeda, Kento Umino, Kaoru Morita, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, et al. Mesenchymal Stromal Cells Inhibit Aerobic Glycolysis in Activated T Cells by Negatively Regulating Hexokinase II Activity Through PD-1/PD-L1 Interaction. TRANSPLANTATION AND CELLULAR THERAPY. 2021. 27. 3
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MISC (31)：
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Professional career (1)：
  • 博士(医学) (自治医科大学)
Work history (3)：
  • 2022/04 - 現在 Jichi Medical University School of Medicine, Department of Biochemistry, Division of Structural Biochemistry Professor
  • 2020/10 - 2022/03 Jichi Medical University Division of Functional Biochemistry, Department of Biochemistry, School of Medicine Professor
  • 2011/04 - 2020/09 Jichi Medical University School of Medicine
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