Kamikubo Yasuhiko

カミクボヤスヒコ | Kamikubo Yasuhiko

Affiliation and department：
Job title： Specific Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60548527.ja.html

Research field (1)： Hematology and oncology

Research keywords (12)： AML1/RUNX1 , ノックアウトマウス , 骨髄異形成症候群 , 癌 , 骨髄ニッチ , ASXL1 , 家族性血小板減少症 , 白血病 , 遺伝子 , 造血幹細胞 , 動物 , CBF白血病

Research theme for competitive and other funds (11)：

2022 - 2025 CROX: Construction of tumor immunity / metastasis control strategy by suppressing RUNX
2019 - 2021 Study to develop nucleic acid analog to inhibit transcription network to maintain glioma stemness
2018 - 2020 Developing novel therapeutics for Translocation Renal Cell Carcinoma by sequence specific DNA alkylation
2017 - 2020 Development of new diagnostic method for refractory maliganant diseases
2017 - 2020 Establishment of novel anti-cancer concept overcoming drug resisitancies.

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Papers (44)：

Masamitsu Mikami, Tatsuya Masuda, Takuya Kanatani, Mina Noura, Katsutsugu Umeda, Hidefumi Hiramatsu, Hirohito Kubota, Tomoo Daifu, Atsushi Iwai, Etsuko Yamamoto Hattori, et al. RUNX1-Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors. Molecules and cells. 2022. 45. 12. 886-895
Yasuzumi Matsui, Yohei Mineharu, Yuki Noguchi, Etsuko Yamamoto Hattori, Hirohito Kubota, Masahiro Hirata, Susumu Miyamoto, Hiroshi Sugiyama, Yoshiki Arakawa, Yasuhiko Kamikubo. Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation. Biochemical and biophysical research communications. 2022. 620. 150-157
Tatsuya Masuda, Shintaro Maeda, Sae Shimada, Naoya Sakuramoto, Ken Morita, Asami Koyama, Kensho Suzuki, Yoshihide Mitsuda, Hidemasa Matsuo, Hirohito Kubota, et al. RUNX1 transactivates BCR-ABL1 expression in Philadelphia chromosome positive acute lymphoblastic leukemia. Cancer science. 2022. 113. 2. 529-539
Satoshi Obu, Katsutsugu Umeda, Hiroo Ueno, Mari Sonoda, Keiji Tasaka, Hideto Ogata, Kagehiro Kouzuki, Seishiro Nodomi, Satoshi Saida, Itaru Kato, et al. CD146 is a potential immunotarget for neuroblastoma. Cancer science. 2021. 112. 11. 4617-4626
Hirohito Kubota, Tatsuya Masuda, Mina Noura, Kana Furuichi, Hidemasa Matsuo, Masahiro Hirata, Tatsuki R. Kataoka, Hidefumi Hiramatsu, Takahiro Yasumi, Tatsutoshi Nakahata, et al. RUNX inhibitor suppresses graft-versus-host disease through targeting RUNX-NFATC2 axis. eJHaem. 2021. 2. 3. 449-458

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MISC (15)：

Kana Nakatani, Hidemasa Matsuo, Yutarou Harata, Moe Higashitani, Asami Koyama, Mina Noura, Yoko Nishinaka-Arai, Yasuhiko Kamikubo, Souichi Adachi. Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia Cells. BLOOD. 2020. 136
松井恭澄, 峰晴陽平, 山本悦子, 荒川芳輝, 上久保靖彦, 足立壮一, 宮本享. A study to develop a chemotherapy inhibiting RUNX transcriptional factors for medulloblastoma. 日本脳腫瘍学会プログラム・抄録集. 2020. 38th
Hidemasa Matsuo, Kenichi Yoshida, Kazutaka Fukumura, Kana Nakatani, Yuki Noguchi, Saho Takasaki, Mina Noura, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, et al. Recurrent Genomic Aberrations of D-Type Cyclins Are Therapeutic Targets of CDK4/6 Inhibitors in t(8;21) and MLL-Rearranged Acute Myeloid Leukemia. BLOOD. 2018. 132
Yuki Noguchi, Natsuki Wariishi, Shiina Iwai, Gengo Kashiwazaki, Junichi Taniguchi, Toshikazu Bando, Masaya Baba, Souichi Adachi, Hiroshi Sugiyama, Yasuhiko Kamikubo. Genetic regulation of RUNX2 induce apoptotic cell death through regulating the expression of SOX2 in CRPC-NE cells. CANCER RESEARCH. 2018. 78. 13
梅田雄嗣, 濱端隆行, 上月景弘, 田中孝之, 加藤格, 馬場志郎, 平松英文, 丹羽明, 齋藤潤, 上久保靖彦, et al. 患者由来iPS細胞を用いたShwachman-Diamond症候群の病態解明. 日本再生医療学会総会(Web). 2018. 17th. ROMBUNNO.O-40-1 (WEB ONLY)

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Professional career (1)：

医学博士 (京都大学)

Work history (1)：

2013 - Osaka University

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