Rchr
J-GLOBAL ID：201401022033812100   Update date: Aug. 24, 2024

Woltjen Knut

Woltjen Knut
Affiliation and department：
Kyoto University Center for iPS Cell Research and Application(CiRA)

About Kyoto University Center for iPS Cell Research and Application(CiRA)


Job title： Associate Professor
Research field  (6)： Genetics ,  Developmental biology ,  Cell biology ,  Medical biochemistry ,  Molecular biology ,  Genomics
Research keywords  (9)： 遺伝子ターゲティング ,  SNP ,  pluripotent stem cells ,  transposons ,  recombinases ,  CRISPR ,  iPS cells ,  molecular genetics ,  genome editing
Research theme for competitive and other funds  (7)：
  • 2021 - 2024 肺オルガノイドを用いた呼吸器病原体の革新的研究基盤の構築と病原性発現機序の解明
  • 2021 - 2024 Evaluating the role of cis-regulatory tandem DNA repeats in human disease and evolution
  • 2021 - 2024 Developing a versatile technique to create transgenic rodents and medium sized animals
  • 2021 - 2023 Regulation of gene expression revealed by genome editing of repetitive and polymorphic cis-elements
  • 2017 - 2020 Establishment of universal iPS cells for regenerative medicine applications through regulated HLA expression
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Papers (85)：
  • Ryo Niwa, Tomoko Matsumoto, Alexander Yusuke Liu, Maki Kawato, Takayuki Kondo, Kayoko Tsukita, Haruhisa Inoue, Thomas Luc Maurissen, Knut Woltjen. Enrichment of allelic editing outcomes by Prime Editing in iPS cells. 2024
  • Eiichi Okamura, Seiya Mizuno, Shoma Matsumoto, Kazuya Murata, Yoko Tanimoto, Dinh Thi Huong Tra, Hayate Suzuki, Woojin Kang, Tomoka Ema, Kento Morimoto, et al. Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation. 2023
  • Takumi Okubo, Nicolas Rivron, Mio Kabata, Hideki Masaki, Keiko Kishimoto, Katsunori Semi, May Nakajima-Koyama, Haruko Kunitomi, Belinda Kaswandy, Hideyuki Sato, et al. Hypoblast from human pluripotent stem cells regulates epiblast development. Nature. 2023
  • Jun Otomo, Knut Woltjen, Hidetoshi Sakurai. Uniform transgene activation in Tet-On systems depends on sustained rtTA expression. iScience. 2023. 26. 10. 107685-107685
  • 中村 桃子, 蝶名林 和久, 丹羽 諒, Woltjen Knut, 越智 陽太郎, 南谷 泰仁, 小川 誠司, 高折 晃史, 吉田 善紀. DDX41の病的バリアントと体細胞変異の機能的差異. 日本血液学会学術集会. 2023. 85回. 48-48
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MISC (17)：
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Patents (1)：
  • Method for genome editing
Books (1)：
  • iPS細胞を用いた正確な ゲノム編集法(MhAX法)
    実験医学 2018
Lectures and oral presentations  (32)：
  • Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
    (2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』 2019)
  • The history and potential of iPSC research
    (AAAS 2019 Annual Meeting 2019)
  • 医療応用に向けたヒトiPS細胞でのゲノム編集
    (OPERA「ゲノム編集」産学共創コンソーシアム・公開シンポジウム、卓越大学院キックオフシンポジウム 2018)
  • Japan’s experience in regenerative medicine and superdonor cells
    (NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’ 2018)
  • Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining
    (Concordia University Seminar 2018)
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Education (3)：
  • 2000 - 2006 University of Calgary Dept. Biochemistry and Molecular Biology, Doctoral Research Program
  • 1998 - 2000 University of Calgary Dept. Biochemistry and Molecular Biology, Masters Research Program
  • 1994 - 1998 University of Alberta Dept. of Biological Sciences, Faculty of Genetics, Molecular Genetics Program
Professional career (1)：
  • 博士(Biochemistry and Molecular Biology) (カルガリー大学)
Work history (6)：
  • 2013/04 - 2018/03 Kyoto University Center for iPS Cell Research and Application (CiRA)/ Hakubi Center for Advanced Research Associate Professor
  • 2010/04 - 2013/03 Kyoto University Center for iPS Cell Research and Application (CiRA) Assistant Professor
  • 2009/02 - 2010/03 Ontario Human iPS Cell Facility The Hospital For Sick Children iPS Cell Facility Manager
  • 2006/09 - 2010/03 Mount Sinai Hospital, Samuel Lunenfeld Research Institute Dr. Andras Nagy Lab Postdoctoral Research Fellow
  • 2005/01 - 2006/08 University of Calgary Centre for Mouse Genomics Molecular/Gene Targeting Consultant
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Committee career (4)：
  • 2018/07 - 現在 Japanese Society for Genome Editing International Committee
  • 2018/07 - 現在 日本ゲノム編集学会 国際委員会委員
  • 2016/07 - 現在 Japanese Society for Genome Editing Public Relations Committee
  • 2016/07 - 現在 日本ゲノム編集学会 広報委員会委員
Awards (1)：
  • 2020/01 - CiRA, Kyoto University 7th Annual CiRA Award For remarkable contributions to collaborative research
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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