Rchr
J-GLOBAL ID：201401025470837480
Update date: Feb. 29, 2024
Okuda Hiroshi
Okuda Hiroshi
Affiliation and department：
Job title：
Assistant Professor
Research field (2)：
Immunology
, Tumor biology
Research theme for competitive and other funds (8)：
- 2023 - 2026 疾病よる転写因子IRF8の発現変化の分子メカニズムの解明
- 2022 - 2025 膵癌における腫瘍関連マクロファージのマスター転写因子を標的とした新規治療法への探索研究
- 2020 - 2023 がん遺伝子MLL-AF4のRNA結合因子による発がん抑制機構
- 2016 - 2020 新規MLL-AEP転写活性化複合体を介した白血病化メカニズム
- 2017 - 2019 Mechanism of leukemogenesis through MLL-AF4 and its regulatory factors
- 2013 - 2015 Mechanisms of niche-independent self-renewal by MLL fusion proteins
- 2013 - 2015 Mechanism of transcriptional activation and leukemogenesis by AF4
- 2011 - 2015 The role of the AEP complex in MLL fusion-dependent leukemogenesis
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Papers (33)：
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Shunichiro Tsukamoto, Toru Suzuki, Hiromichi Wakui, Tatsuki Uehara, Juri Ichikawa, Hiroshi Okuda, Kotaro Haruhara, Kengo Azushima, Eriko Abe, Shohei Tanaka, et al. Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity. Metabolism. 2023. 149. 155706-155706
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Hiroshi Okuda, Ryo Miyamoto, Satoshi Takahashi, Takeshi Kawamura, Juri Ichikawa, Ibuki Harada, Tomohiko Tamura, Akihiko Yokoyama. RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4. Nature Communications. 2022. 13. 1
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Satoshi Takahashi, Akinori Kanai, Hiroshi Okuda, Ryo Miyamoto, Yosuke Komata, Takeshi Kawamura, Hirotaka Matsui, Toshiya Inaba, Akifumi Takaori-Kondo, Akihiko Yokoyama. HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis. eLife. 2021. 10
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Ryo Miyamoto, Akinori Kanai, Hiroshi Okuda, Yosuke Komata, Satoshi Takahashi, Hirotaka Matsui, Toshiya Inaba, Akihiko Yokoyama. HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways. eLife. 2021. 10
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Nikola Sekulovski, James A MacLean, Sambasiva R Bheemireddy, Zhifeng Yu, Hiroshi Okuda, Cindy Pru, Kyle N Plunkett, Martin Matzuk, Kanako Hayashi. Niclosamide’s potential direct targets in ovarian cancer. Biology of Reproduction. 2021. 105. 2. 403-412
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MISC (8)：
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Akihiko Yokoyama, Hiroshi Okuda. The Molecular Mechanism of Transcriptional Activation By MLL-AEP Fusion Proteins. BLOOD. 2015. 126. 23
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Sambad Sharma, Hiroshi Okuda, Fei Xing, Aya Kobayashi, Misako Watabe, Puspa R. Pandey, Sudha K. Pai, Wen Liu, Koji Fukuda, Megumi Iiizumi, et al. HAS2 promotes tumor progression by stimulating interaction of cancer stem-like cells with tumor associated macrophage and stromal cells through a paracrine loop of growth factors in the bone. CANCER RESEARCH. 2013. 73. 8
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Hiroshi Okuda, Fei Xing, Aya Kobayashi, Misako Watabe, Sudha K. Pai, Wen Liu, Puspa R. Pandey, Koji Fukuda, Megumi Iiizumi. Hyaluronan synthase 2 promotes breast cancer bone metastasis by stimulating interaction of cancer stem-like cells with tumor-associated macrophage. CANCER RESEARCH. 2012. 72
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Fei Xing, Aya Kobayashi, Hiroshi Okuda, Misako Watabe, Puspa R. Pandey, Sudha K. Pai, Koji Fukuda, Megumi Iiizumi, Kounosuke Watabe. Reactive astrocytes promote the growth of cancer stem-like cells of metastatic breast tumor by activating Notch signaling in brain. CANCER RESEARCH. 2012. 72
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Aya Kobayashi, Hiroshi Okuda, Fei Xing, Puspa R. Pandey, Misako Watabe, Shigeru Hirota, Sudha K. Pai, Wen Liu, Koji Fukuda, Christopher Chambers, et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone (vol 19, pg 2641, 2011). JOURNAL OF EXPERIMENTAL MEDICINE. 2012. 209. 3. 639-639
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Education (3)：
- 2004 - 2007 Kindai University Graduate School of Agriculture Major in Advanced life Science
- 2002 - 2004 Kindai University Graduate School of Agriculture Major in Advanced life Science
- 1998 - 2002 Kindai University Faculty of Agriculture
Professional career (1)：
Work history (6)：
Association Membership(s) (4)：
日本免疫学会
, 日本分子生物学会
, 日本血液学会
, 日本癌学会
