Sasaki Mariko

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://sasaki-lab.labby.jp/

Research field (1)： Molecular biology

Research keywords (10)： ecDNA , rDNA , Extrachromosomal DNA circle , Genome changes , DNA double-strand break , DNA replication stress , Genome rearrangements , Homologous recombination , Cancer , chromatin

Research theme for competitive and other funds (9)：

2022 - 2029 染色体外環状DNAの包括的理解とその応用
2024 - 2027 リボソームDNAのコピー数変化に対する生物応答力の解明
2020 - 2023 Understanding the mechanisms by which Ctf4 protein suppresses repair of DNA double-strand breaks by homologous recombination
2020 - 2022 Understanding the mechanisms by which chromatin assembly factors promote the maintenance of genome stability upon inhibition of DNA replication
2018 - 2020 DNA二重鎖切断修復によるゲノム安定性維持機構の4D情報

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Papers (21)：

Junno Ohira, Mariko Sasaki, Takehiko Kobayashi. The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster. bioRxiv. 2024
Hajime Futami, Mariko Sasaki, Takehiko Kobayashi. The histone chaperone CAF-1 maintains the stability of the ribosomal RNA gene cluster by suppressing end resection of replication-associated DNA double-strand breaks. bioRxiv. 2024
Acidic growth conditions stabilize the ribosomal RNA gene cluster and extend lifespan through noncoding transcription repression. Genes to Cells. 2024. 29. 2. 111-130
Mariko Sasaki, Takehiko Kobayashi. Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes. bioRxiv. 2023
Mariko Sasaki, Takehiko Kobayashi. Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks. Genes & Genetic Systems. 2023. 98. 3. 103-119

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Lectures and oral presentations (39)：

Nearby transcription activity impacts repair pathway choice of DSBs that are formed in response to replication fork arrest
(The 96th annual meeting of the Japanese Biochemical Society 2023)
Mechanism and Impact of DNA quantity changes ~understanding as-yet unidentified potential of circular DNA~
(Joint Symposium of Shizuoka University and National Institute of Genetics 2023)
Transcription near arrested DNA replication forks triggers rDNA copy number changes.
(The 2023 Cold Spring Harbor Asia Conference on YEAST AND LIFE SCIENCES 2023)
Understanding mechanisms underlying extrachromosomal circular DNA using budding yeast
(The 82nd annual meeting of the Japanese Cancer Association 2023)
構造特異的ヌクレアーゼRad27(FEN-1)によるrDNA安定性維持機構の解析
(日本遺伝学会第95回大会 2023)

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Education (3)：

2004 - 2012 米国Weill Cornell Graduate School of Medical Sciences (Ph.D. program)/Memorial Sloan Kettering Cancer Center (Scott Keeney laboratory) Molecular Biology Program
2001 - 2004 Osaka University
1997 - 2001 Osaka University School of Engineering

Professional career (1)：

Ph.D. (Cornell University)

Work history (5)：

2023/04 - 現在 National Institute of Genetics National Institute of Genetics
2022/04 - 2023/03 The University of Tokyo Institute for Quantitative Biosciences, Laboratory of Genome Regeneration
2018/04 - 2022/03 The University of Tokyo
2015/04 - 2018/03 The University of Tokyo
2012/04 - 2015/03 National Institute of Genetics

Committee career (1)：

2021/04 - 現在 The Genetics Society of Japan committee

Awards (11)：

2024 - 公益財団法人がん研究振興財団がん研究助成金がん化促進因子ecDNAが複製される分子メカニズムの解明
2023 - The Sumitomo Foundation, Basic Science Research Project
2021 - The Naito Foundation Research Grant
2020 - Genes & Genetic Systems GGS prize 2020
2019/09 - 日本遺伝学会奨励賞 DNA複製阻害時のDNA二本鎖切断修復機構に関する研究

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Association Membership(s) (2)：

日本分子生物学会 , 日本遺伝学会

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