Mizutani Tatsuaki

ミズタニタツアキ | Mizutani Tatsuaki

Affiliation and department：
Job title： Senior lecturer

Research field (8)： Immunology , Cell biology , Tumor biology , Molecular biology , Laboratory animal science , Experimental pathology , Structural biochemistry , Pathobiochemistry

Research keywords (8)： tumor immunology , 好中球 , マクロファージ , 血液腫瘍 , erythrocyte , GFPイメージング , FRET , 結晶構造解析

Research theme for competitive and other funds (5)：

2022 - 2025 癌助長性好中球におけるS100A9依存的転写制御メカニズムの解明
2017 - 2020 Regulation of macrophages polarization by neutrophils: implication in tuberculosis and cancer pathology
2014 - 2017 Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery
2014 - 2016 Revealing the mechanism of the tumor initiation and development due to the tumor immunosuppression by Prothymosin-alpha.
2006 - 2007 骨髄幹細胞から免疫細胞への分化制御における分子基盤の解明

Papers (23)：

Tatsuaki Mizutani, Toshiaki Ano, Yuya Yoshioka, Satoshi Mizuta, Keiko Takemoto, Yuki Ouchi, Daisuke Morita, Satsuki Kitano, Hitoshi Miyachi, Tatsuaki Tsuruyama, et al. Neutrophil S100A9 supports M2 macrophage niche formation in granulomas. iScience. 2023. 106081-106081
Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita. Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding. Journal of Biological Chemistry. 2022. 298. 7. 102100-102100
Shuzo Urata, Olaposi Idowu Omotuyi, Ayako Izumisawa, Takeshi Ishikawa, Satoshi Mizuta, Yasuteru Sakurai, Tatsuaki Mizutani, Hiroshi Ueda, Yoshimasa Tanaka, Jiro Yasuda. Identification of novel chemical compounds targeting filovirus VP40-mediated particle production. Antiviral Research. 2022. 199. 105267-105267
Daisuke Morita, Chieri Iwashita, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita. Crystal structure of the ternary complex of TCR, MHC class I, and lipopeptides. International immunology. 2020. 32. 12. 805-810
Yoko Shima, Daisuke Morita, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita. Crystal structures of lysophospholipid-bound MHC class I molecules. The Journal of biological chemistry. 2020. 295. 20. 6983-6991

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MISC (22)：

水谷龍明, 杉田昌彦. 肉芽腫深部における好中球主導型マクロファージM2化機構. 医学の歩み. 2024. 289. 12. 907-908
水谷龍明, 大場雄介, 水田賢志, 浦田秀造. アレナウイルスZ蛋白の自己重合を検出するFRETバイオセンサーの開発と,それを利用した抗ウイルス薬スクリーニング法の確立. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
泉澤文子, 水谷龍明, 浦田秀造. 【グローバル時代の新興再興感染症への科学的アプローチ】デング・ジカ・SFTS・出血熱へのアプローチラッサウイルス・エボラウイルスに対する創薬研究. 生体の科学. 2021. 72. 4. 326-329
大和勇輝, 水谷龍明. S100A9は抗腫瘍型M1-TAMを誘導し、腫瘍成長を抑制する. 日本癌学会総会記事. 2020. 79回. OJ12-2
浦田秀造, 浦田秀造, OMOTUYI Olaposi Idowu, 石川岳志, 水田賢志, 櫻井康晃, 櫻井康晃, 水谷龍明, 植田弘師, 田中義正, et al. Identification of novel chemical compounds which inhibited filovirus VP40-mediated virus-like particle (VLP) production. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web). 27F-pm12

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Lectures and oral presentations (7)：

Neutrophil/macrophage interactions in deep granulomas
(2023)
Neutrophil S100A9-Cox2 axis dictates the formation of the M2 macrophage niche in granulomas
(The 29th East Asia Joint Symposium 2023)
好中球S100A9による肉芽腫M2マクロファージの誘導機序,
(第34回日本生体防御学会学術総会, 2023)
STAT3β plays a tumor-suppressive role in acute myeloid leukemia
(2023)
肉芽腫形成を制御するS100A9
(第29回日本生体防御学会学術総会 2018)

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Education (3)：

2003 - 2007 The University of Tokyo Graduate School of Medicine
2001 - 2003 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1996 - 2001 Tokyo Institute of Technology School of Bioscience and Biotechnology

Professional career (1)：

博士 (東京大学)

Work history (7)：

2023/12 - 現在 Hokkaido University Departmen of Cell Physiology Faculty of Medicine Senior lecturer
2022/04 - 2023/11 Institute for Life and Medical Sciences, Kyoto University. Lab of Cell Regulation Assistant Professor
2017/01 - 2022/03 Institute for Frontier Life and Medical Sciences Kyoto University Assistant professor
2014/07 - 2016/12 Institute for virus research Kyoto university Assistant professor
2013/02 - 2014/06 Nagasaki University Assistant professor

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Awards (2)：

2010/05 - Austrian Champions in European Research
2007/05 - 東京免疫フォーラム若手奨励賞

Association Membership(s) (2)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION

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