Togashi Yu

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： http://www-user.yokohama-cu.ac.jp/~nai3naib/wp/

Research field (1)： Metabolism and endocrinology

Research keywords (2)：膵β細胞量 , 2型糖尿病

Research theme for competitive and other funds (6)：

2022 - 2025 リン酸化プロテオミクスによる膵切除後膵β細胞増殖機構の解明
2020 - 2023 Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity
2018 - 2021 A novel sarcopenia model by insulin / IGF-1 receptor inhibition
2016 - 2019 Fate determination of pancreatic beta cells by glucokinase activation
2016 - 2018 The mechanism of recovery after inhibition of insulin receptor and IGF-1 receptor in pancreatic beta cells, liver, adipose tissue.

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Papers (40)：

Kuniyuki Nishiyama, Masato Ono, Takahiro Tsuno, Ryota Inoue, Ayako Fukunaka, Tomoko Okuyama, Mayu Kyohara, Yu Togashi, Setsuko Fukushima, Takuto Atsumi, et al. Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice. Endocrinology. 2023. 164. 8
Daisuke Miyashita, Ryota Inoue, Takahiro Tsuno, Tomoko Okuyama, Mayu Kyohara, Chigusa Nakahashi-Oda, Kuniyuki Nishiyama, Setsuko Fukushima, Yutaro Inada, Yu Togashi, et al. Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes. iScience. 2022. 25. 12. 105662-105662
Yu Togashi, Daisuke Miyashita, Takahiro Tsuno, Ryota Inoue, Tomoko Okuyama, Mayu Kyohara, Kuniyuki Nishiyama, Masanori Arai, Kenta Kanematsu, Soichiro Kanataki, et al. Abdominal aortic calcification is associated with Fibrosis-4 index and low body mass index in type 2 diabetes patients: A retrospective cross-sectional study. Journal of diabetes investigation. 2022. 13. 11. 1861-1872
Jinghe Li, Ryota Inoue, Yu Togashi, Tomoko Okuyama, Aoi Satoh, Mayu Kyohara, Kuniyuki Nishiyama, Takahiro Tsuno, Daisuke Miyashita, Tatsuya Kin, et al. Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway. Diabetes. 2022. 71. 3. 424-439
Sakiko Terui, Ryoichi Akamatsu, Masanori Arai, Ryota Inoue, Tomoko Okuyama, Mayu Kyohara, Jinghe Li, Takahiro Tsuno, Daisuke Miyashita, Yu Togashi, et al. Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2021. 12. 11. 2873-2889

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MISC (20)：

H. Inoue, J. Shirakawa, K. Orime, Y. Togashi, K. Tajima, Y. Terauchi. The role of S100A8 and S100A9 in inflammatory interaction between pancreatic islets and macrophages. DIABETOLOGIA. 2014. 57. S304-S304
Jun Shirakawa, Tomoko Okuyama, Eiko Yoshida, Mari Shimizu, Yuka Horigome, Takayuki Tuno, Moe Hayasaka, Shiori Abe, Masahiro Fuse, Yu Togashi, et al. Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice. Endocrinology. 2014. 155. 6. 2102-11
Yu Togashi, Jun Shirakawa, Kazuki Orime, Mitsuyo Kaji, Eri Sakamoto, Kazuki Tajima, Hideaki Inoue, Akinobu Nakamura, Yoshihiro Tochino, Yoshio Goshima, et al. β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. Endocrinology. 2014. 155. 5. 1643-52
Jun Shirakawa, Yuko Murohashi, Noriko Okazaki, Shunsuke Yamazaki, Tetsuya Tamura, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi. Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy. Endocrine journal. 2014. 61. 11. 1115-23
Jun Shirakawa, Yu Togashi, Eri Sakamoto, Mitsuyo Kaji, Kazuki Tajima, Kazuki Orime, Hideaki Inoue, Naoto Kubota, Takashi Kadowaki, Yasuo Terauchi. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells. Diabetes. 2013. 62. 10. 3448-58

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Professional career (1)：

医学博士 (横浜市立大学)

Work history (3)：

2014 - Yokohama City University
Yokohama City University Hospital, Endocrinology/Diabetes and Metabolism
Yokohama City University School of Medicine Medical Course Assistant Professor

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