Rchr
J-GLOBAL ID：201401038787297205
Update date: Jan. 31, 2024
Fujihashi Masahiro
フジハシ マサヒロ | Fujihashi Masahiro
Affiliation and department：
Research field (1)：
Structural biochemistry
Research theme for competitive and other funds (15)：
- 2021 - 2024 Mass identification and modification of pyrophosphate-dependent kinases based on their three-dimensional structures
- 2020 - 2023 放射光と中性子の連携利用による電子伝達タンパク質の精密構造解析
- 2019 - 2022 multiple identification of non-ATP-dependent kinases based on registered crystal structures of enzymes with unknown function
- 2019 - 2021 Research on Mining, functional analysis, and modification of biosynthetic enzymes based on three-dimensional structure
- 2018 - 2021 Discovery of new terpene cyclization pathway and identification of various novel terpenes
- 2017 - 2020 Structural Biology of Molecular Mechanism of Hydrogenase Maturation Proteins
- 2017 - 2019 新規酵素の立体構造を基にした、有用酵素のマイニングと機能改良
- 2016 - 2019 Experimental analysis of the electrostatic repulsion between enzyme and substrates to elucidate the reaction mechanism, and development anti-malaria agent
- 2013 - 2016 Creation of novel terpenoids from biosynthetic study on sesquarterpene
- 2012 - 2015 Elucidation of catalytic mechanism of two characteristic enzymes and its application based on crystal structures.
- 2010 - 2011 Investigation of the reaction mechanism of orotidine monophosphate decarboxylase using the distortion of the substrate
- 2008 - 2009 Investigation of the structural change of orotidine 5'-monophosphate decarboxylase during the reaction and its catalytic mechanism
- 2005 - 2007 結晶構造の時間変化からみるオロチジン-リン酸脱炭酸酵素の反応触媒機構
- 2004 - 2004 酵素の反応時における立体構造変化を含む詳細な反応触媒機構の解析
- 2002 - 2004 Structure and Function of DNA Repair Enzyme and Their Homologous Proteins
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Papers (55)：
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Shogo Iwakata, Kazuya Asada, Tomoyuki Nishi, Rafaella Stepanova, So Shinoda, Daijiro Ueda, Masahiro Fujihashi, Yoko Yasuno, Tetsuro Shinada, Tsutomu Sato. Insight into the mechanism of geranyl-β-phellandrene formation catalyzed by Class IB terpene synthases. Bioscience, biotechnology, and biochemistry. 2022. 86. 6. 724-729
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Yasunobu Mori, Hiroki Kawamura, Takaaki Sato, Takayuki Fujita, Ryuhei Nagata, Masahiro Fujihashi, Kunio Miki, Haruyuki Atomi. Identification and enzymatic analysis of an archaeal ATP-dependent serine kinase from the hyperthermophilic archaeon Staphylothermus marinus. Journal of Bacteriology. 2021
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Ryo Tashiro, Takaaki Sato, Haruyuki Atomi, Kunio Miki, Masahiro Fujihashi. Altering the Phosphorylation Position of Pyrophosphate-Dependent myo-Inositol-1-Kinase Based on Its Crystal Structure. ACS Chemical Biology. 2021. 16. 5. 794-799
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Rafaella Stepanova, Hayato Inagi, Kei Sugawara, Kazuya Asada, Tomoyuki Nishi, Daijiro Ueda, Yoko Yasuno, Tetsuro Shinada, Kunio Miki, Masahiro Fujihashi, et al. Characterization of Class IB Terpene Synthase: The First Crystal Structure Bound with a Substrate Surrogate. ACS chemical biology. 2020. 15. 6. 1517-1525
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Ryuhei Nagata, Masahiro Fujihashi, Takaaki Sato, Haruyuki Atomi, Kunio Miki. Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants. Nature Communications. 2018. 9. 1. 1765
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MISC (32)：
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Masahiro FUJIHASHI. Crystallographic Analysis with Anomalous Dispersion Effects of Phosphorus Atoms Using Remote and Automated Measurements. Nihon Kessho Gakkaishi. 2021. 63. 3. 222-223
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浅田和也, 上田大次郎, 三木邦夫, 藤橋雅宏, 品田哲郎, 佐藤努. Analysis of cyclic structure formation mechanism of class IB terpene synthase. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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金本壮平, 佐藤努, 品田哲朗, 三木邦夫, 深井周也, 藤橋雅宏. クラスIB大型テルペン合成酵素の基質複合体の結晶構造. 日本結晶学会年会講演要旨集. 2020. 2020 (CD-ROM)
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藤橋雅宏, 稲木隼人, 西智之, 上田大次郎, 佐藤努, 品田哲朗, 三木邦夫. Class IB大型テルペン合成酵素の基質認識機構の解析. イソプレノイド研究会例会講演要旨集. 2019. 29th
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稲木隼人, 佐藤努, 保野陽子, 品田哲郎, 三木邦夫, 藤橋雅宏. Analysis of ligand-recognition mechanism of class IB terpene synthase. 量子ビームサイエンスフェスタ(Web). 2019. 2018
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Books (1)：
Professional career (1)：
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