Okuda Hiroko

Research field (3)： Hygiene and public health (laboratory) , Genetics , Neuroscience - general

Research keywords (5)：遺伝性疾患 , 神経科学 , 遺伝疫学 , 衛生学 , 小児四肢疼痛発作症

Research theme for competitive and other funds (5)：

2021 - 2024 Elucidation of infantile episodic limb pain mechanism induced by cold exposure
2020 - 2023 Investigation of mechanisms of pain evoked by meteorological environment
2017 - 2021 Mechanisms of temperature- and pressure-induced pain
2016 - 2019 Role of mitochondrial Ca2+ transporter in vascular function and vascular diseases
2015 - 2019 Functional analysis of novel mutations of SCN11A for future drug of familial episodic pain

Papers (46)：

Atsuko Noguchi, Tohru Tezuka, Hiroko Okuda, Hatasu Kobayashi, Kouji H. Harada, Takeshi Yoshida, Shinji Akioka, Keiko Wada, Aya Takeya, Risako Kabata-Murasawa, et al. Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic Criteria. International Journal of Molecular Sciences. 2024. 25. 13. 6832-6832
峰晴陽平, 鎌田貴彦, 松井恭澄, 手塚徹, 尾市雄輝, 森本貴昭, 丹治正大, 小林果, 奥田裕子, 原田浩二, et al. RNF213欠損は髄芽腫の腫瘍形成能を亢進させ、GAS6を介して低栄養への抵抗性を誘発する(RNF213 regulates tumorgenity and induces starvation resistance via GAS6 in medulloblastoma). 日本癌学会総会記事. 2023. 82回. 1816-1816
Kouji H. Harada, Hiroko Okuda. Correspondence on “Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish”. Environmental Science & Technology. 2023. 57. 33. 12339-12339
Hiroko Okuda, Sumiko Inoue, Yoshihiro Oyamada, Akio Koizumi, Shohab Youssefian. Reduced pain sensitivity of episodic pain syndrome model mice carrying a Nav1.9 mutation by ANP-230, a novel sodium channel blocker. Heliyon. 2023. 9. 4. e15423
Sharif Ahmed, Toshiyuki Habu, Jiyeong Kim, Hiroko Okuda, Shinji Oikawa, Mariko Murata, Akio Koizumi, Hatasu Kobayashi. Suppression of RNF213, a susceptibility gene for moyamoya disease, inhibits endoplasmic reticulum stress through SEL1L upregulation. Biochemical and Biophysical Research Communications. 2022. 609. 62-68

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MISC (45)：

鎌田貴彦, 鎌田貴彦, 峰晴陽平, 松井恭澄, 手塚徹, 尾市雄輝, 森本貴昭, 丹治正大, 佐野徳隆, 寺田行範, et al. Absence of RNF213 in medulloblastoma induces starvation resistance via GAS6 and results in tumor progression. 日本脳腫瘍学会学術集会プログラム・抄録集. 2023. 41st
松井恭澄, 峰晴陽平, 鎌田貴彦, 手塚徹, 尾市雄輝, 森本貴昭, 丹治正大, 小林果, 奥田裕子, 原田浩二, et al. RNF213 deficiency in medulloblastoma promotes tumor development via enhanced PDGFRA expression. 日本脳腫瘍学会学術集会プログラム・抄録集. 2023. 41st
Yohei Mineharu, Yuki Oichi, Takahiko Kamata, Yasuzumi Matsui, Takaaki Morimoto, Masahiro Tanji, Hatasu Kobayashi, Hiroko Okuda, Kouji H. Harada, Akio Koizumi, et al. SIGNIFICANCE OF RNF213 IN TUMORGENICITY OF MEDULLOBLASTOMA. NEURO-ONCOLOGY. 2020. 22. 402-402
小林果, 西村泰光, 奥田裕子, 原田浩二, 加畑理咲子, 武田美都里, 崔廷米, Youssefian Shohab, 大槻剛巳, 小泉昭夫. Rnf213遺伝子改変マウスにおける免疫細胞・血清サイトカインの系統的解析. 日本衛生学雑誌. 2019. 74. Suppl. S121-S121
奥田裕子, 加畑理咲子, 小林果, 人見敏明, 原田浩二, 小泉昭夫. 小児四肢疼痛発作症の新規変異における電気生理学的特徴. 日本衛生学雑誌. 2019. 74. Suppl. S176-S176

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