Rchr
J-GLOBAL ID：201401042230227449   Update date: Aug. 06, 2024

Kodan Atsushi

コダン アツシ | Kodan Atsushi
Affiliation and department：
Kyoto University Institute for Advanced Study

About Kyoto University Institute for Advanced Study


Job title： Program-Specific Associate Professor
Other affiliations (1)：
Research field  (6)： Nutrition and health science ,  Molecular biology ,  Cell biology ,  Pharmacology ,  Structural biochemistry ,  Applied biochemistry
Research keywords  (7)： 脂質代謝 ,  nascent HDL ,  drug discovery ,  structure based molecular mechanism ,  conformational change ,  conformation and activity relationship ,  biological macromolecule
Research theme for competitive and other funds  (7)：
  • 2021 - 2025 細胞外基質による細胞機能制御機構の包括的理解とその応用基盤の研究
  • 2020 - 2023 脂質輸送型ABC蛋白質の分子構造と役割の解明
  • 2017 - 2020 Structural Basis for drug transport by ABC transporters
  • 2012 - 2015 Elucidation of the molecular mechanism of ABC transporters
  • 2010 - 2011 X-ray crystallographic analysis of an ABC transporter
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Papers (21)：
  • Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
  • Fumihiko Ogasawara, Atsushi Kodan, Kazumitsu Ueda. ABC proteins in evolution. FEBS letters. 2020. 594. 23. 3876-3881
  • Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda. In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein. Journal of Biological Chemistry. 2020. 295. 15. 5002-5011
  • Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda. The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells. bioRxiv. 2019
  • Kodan A, Yamaguchi T, Nakatsu T, Matsuoka K, Kimura Y, Ueda K, Kato H. Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1. Nature communications. 2019. 10. 1. 88-88
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MISC (59)：
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Books (5)：
  • BIOSCIENCE & INDUSTRY
    2021
  • ファルマシア
    日本薬学会 2020
  • 膜タンパク質工学ハンドブック
    エヌ・ティー・エス 2020 ISBN:9784860435370
  • 未来材料
    エヌ・ティー・エス 2006
  • ABC蛋白質
    学会出版センター 2005 ISBN:4762230421
Lectures and oral presentations  (8)：
  • Direct Visualization of ABCA1 Reconstituted in Nanodisc by High-Speed Atomic Force Microscopy (HS-AFM)
    (ABC2023, the 9th FEBS Special Meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Disease” Innsbruck, Austria 2023)
  • Cryo-EM解析を目指した脂質輸送型ABC蛋白質の生産・調製基盤の構築
    (日本農芸化学大会2021年度大会 (オンライン開催) 2021)
  • 多剤排出ポンプMDR1の薬剤絞り出しメカニズム
    (第15回トランスポーター研究会年会 (オンライン開催) 2020)
  • Structural basis for gating mechanisms of a eukaryotic ABC transporter
    (WPI-iCeMS Industry Advisory Committee Conference 2014)
  • High-resolution crystal structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote
    (ABC2014, the 5th FEBS Special Meeting “ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease” 2014)
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Professional career (1)：
  • Ph.D. (Kyoto University)
Association Membership(s) (4)：
Japan Society for Bioscience, Biotechnology, and Agrochemistry ,  SPring-8ユーザー共同体(SPRUC)X線自由電子レーザーXFEL利用研究会会員 ,  SPring-8ユーザー共同体(SPRUC)放射光構造生物学研究会 ,  The Japanese Biochemical Society
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