Daichi Morimoto

モリモトダイチ | Daichi Morimoto

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.moleng.kyoto-u.ac.jp/~moleng_01/

Research field (5)： Structural biochemistry , Biophysics , Molecular biology , Bio-, chemical, and soft-matter physics , Cell biology

Research keywords (4)： Rheo-NMR , Ubiquitin , Biophysics , Structural Biology

Research theme for competitive and other funds (22)：

2023 - 2030 生体内の流れによるタンパク質の構造破壊の理解
2022 - 2026 Development of analytical platform for proteins in electric field and its application
2024 - 2025 タンパク質の細胞内再利用の絶対定量による新規細胞診断技術の開発
2022 - 2025 ユビキチン鎖の形状とストレス顆粒に関わる物性との関係の解明
2021 - 2024 Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation

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Papers (46)：

Tomoki Sorada, Erik Walinda, Daichi Morimoto. Cyclization of ubiquitin chains reinforces their recognition by ZNF216. FEBS Letters. 2024
Tomoki Sorada, Erik Walinda, Masahiro Shirakawa, Kenji Sugase, Daichi Morimoto. An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi-domain protein. Protein Science. 2023
Yusuke Shuto, Erik Walinda, Daichi Morimoto, Kenji Sugase. Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields. The Journal of Physical Chemistry B. 2023
Erik Walinda, Kenji Sugase, Naoki Ishii, Masahiro Shirakawa, Kazuhiro Iwai, Daichi Morimoto. Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity. Journal of Biological Chemistry. 2023. 105165-105165
T Sorada, D Morimoto, E Walinda, K Sugase. Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1 (vol 562, pg 94, 2021). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023. 660. 100

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MISC (4)：

森本大智, ヴァリンダ・エリック, 深田はるみ, 菅瀬謙治, 蔭山俊, 星野大, 難波啓一, 小松雅明, 田中啓二, 白川昌宏. タンパク質の構造破綻とその関連疾患物性化学から臨床まで細胞内におけるユビキチン陽性タンパク質凝集体の形成機構の解明. 日本生化学会大会プログラム・講演要旨集. 2016. 89回. [1S07-3]
森本大智, WALINDA Erik, 菅瀬謙治, 深田はるみ, 曽友深, 蔭山俊, 蔭山俊, 星野大, 藤井高志, 土屋光, et al. ユビキチン化に伴うタンパク質構造不安定化. Abstracts. Annual Meeting of the NMR Society of Japan. 2014. 53rd
森本大智, 磯貝信, 阿部翔吾, 有田恭平, 雲財悟, 天野剛志, 有吉眞理子, 杤尾豪人, 小松雅明, 田中啓二, et al. p62 UBAドメインのユビキチン認識機構の構造学的研究. 日本生化学会大会プログラム・講演要旨集. 2009. 82回. 3P-449
Shin Isogai, Takeshi Tenno, Morimoto Daichi, Abe Shogo, Tochio Hidehito, Arita Kyouhei, Ariyoshi Mariko, Tanaka Keiji, Shirakawa Masahiro. Crystal structure of p62 ubiquitin associated (UBA) domain. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2008. 64. C325-C325

Patents (1)：

Books (7)：

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Lectures and oral presentations (25)：

生体内の流れによるタンパク質の構造破壊
(第1回CCC講演会 2023)
生体内環境がタンパク質凝集に与える影響
(第8回生体分子凝縮体勉強会 2023)
Elucidation of structural dynamics of a cyclic multi-domain protein by an integrated approach of NMR relaxation experiments and coarse-grained MD simulations
(2023)
Atomic-level elucidation of amyloid formation mechanism by NMR spectroscopy
(第61回NMR討論会 2022)
レオロジーNMR法によるSOD1アミロイド形成の多状態その場観察
(第60回日本生物物理学会年会 2022)

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Education (3)：

2011 - 2015 Kyoto University Graduate School of Engineering Department of Molecular Engineering
2009 - 2011 Kyoto University Graduate School of Engineering Department of Molecular Engineering
2005 - 2009 Kyoto University Faculty of Engineering Industrial Chemistry

Professional career (1)：

Work history (2)：

Committee career (5)：

Awards (7)：

2022/11 - The Nuclear Magnetic Resonance Society of Japan Young Scientist Award
2022/06 - Protein Science Society of Japan Young Scientist Award
2015/09 - The Biophysical Society of Japan Early Career Presentation Award
2014/11 - The Nuclear Magnetic Resonance Society of Japan Young scientist travel award
2014/11 - The Nuclear Magnetic Resonance Society of Japan JEOL RESONANCE award at the 53rd Annual Meeting of the NMR Society of Japan

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Association Membership(s) (3)：

Protein Science Society of Japan , The Biophysical Society of Japan , The Nuclear Magnetic Resonance Society of Japan

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