Nagai Yuji

ナガイユウジ | Nagai Yuji

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/20415409.ja.html

Research keywords (9)： chemogenetics , 分子イメージング , PET , 獣医放射線学 , 神経科学 , 包括脳ネットワーク , 核医学(PETを含む) , ポジトロンCT , トランスレーショナルリサーチ

Research theme for competitive and other funds (7)：

2023 - 2027 化学遺伝学技術を利用した精神・神経疾患霊長類モデル動物作出技術の確立
2019 - 2022 Optimization of DREADDs technology to the non-human primate brain using in vivo imaging
2014 - 2018 Neural mechanism of cost-benefit based controlling motivation
2015 - 2017 In vivo neural projection mapping technology with a novel PET ligand
2011 - 2012 In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's disease

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Papers (81)：

Yukiko Hori, Haruhiko Iwaoki, Koki Mimura, Yuji Nagai, Makoto Higuchi, Takafumi Minamimoto. Effects of a 5-HT4 receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task. Scientific reports. 2024. 14. 1. 19619-19619
Toshiyuki Hirabayashi, Yuji Nagai, Yuki Hori, Yukiko Hori, Kei Oyama, Koki Mimura, Naohisa Miyakawa, Haruhiko Iwaoki, Ken-Ichi Inoue, Tetsuya Suhara, et al. Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates. Nature communications. 2024. 15. 1. 5369-5369
Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, et al. Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases. Neuron. 2024
Takafumi MINAMIMOTO, Yuji NAGAI, Kei OYAMA. Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates. Proceedings of the Japan Academy, Series B. 2024
Kei Oyama, Yuji Nagai, Takafumi Minamimoto. Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections. Bio-protocol. 2023. 13. 23. e4897

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MISC (59)：

山崎友照, 藤永雅之, 大久保崇之, 大久保崇之, 下條雅文, 小野麻衣子, 永井裕司, 小川政直, 念垣信樹, 小川政直, et al. 新規レポーター遺伝子イメージング剤[¹⁸F]FE-TMP-d4の小動物を用いた有効性評価. 核医学(Web). 2023. 60. Supplement
大久保崇之, 大久保崇之, 下條雅文, 小野麻衣子, 藤永雅之, 小川政直, 小川政直, 念垣信樹, 念垣信樹, 永井裕司, et al. ecDHFRイメージング用の遺伝子レポータートPETトレーサー[18F]FHP-TMPの開発. 核医学(Web). 2022. 59. Supplement
小野麻衣子, 高橋真奈美, 下沢明希, 藤永雅之, 森若菜, 永井裕司, 三村喬生, 熊田勝志, 下條雅文, 高堂裕平, et al. α-synuclein病変の蓄積・伝播を生体脳で可視化する分子プローブの開発. Dementia Japan. 2021. 35. 4
永井裕司, 宮川尚久, Haung Xi-Ping, Slocum Samuel T., Xiong Yan, 堀由紀子, 小山佳, 季斌, 平林敏行, 藤本淳, et al. 化学遺伝学とPETイメージングによるサル脳活動操作とモニタリング. 日本獣医麻酔外科学雑誌. 2019. 50. Suppl.2. 316-316
Oyama K, Hori Y, Nagai Y, Hirabayashi T, Miyakawa N, Fujimoto A, Mimura K, Inoue K, Eldridge A M, Saunders C R, et al. DREADD inactivation of orbitofrontal cortex revealed its critical role in reward-based adaptive decision making in monkeys. 2019

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Lectures and oral presentations (53)：

神経活動を選択的に制御できる人工受容体DREADDのPETイメージング
(第58回日本獣医画像診断学会 2015)
サルの報酬関連行動に影響を与える人工受容体DREADDのPETイメージング
(第30回日本大脳基底核研究会 2015)
In vivo PET imaging of the behaviorally active designer receptor in macaques
(第37回日本神経科学大会 2014)
Serotonergic dysfunction mediates decrease in motivation for instrumental action in hypothyroidism model monkeys
(8th IBRO World Congress of Neuroscience 2011)
Alteration of dopaminergic function in a primate model of hypothyroidism revealed by PET
(第34回日本神経科学大会 2011)

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Professional career (1)：

Work history (4)：

2024/04 - 現在 National Institutes for Quantum Science and Technology Institute for Quantum Medical Science, Advanced Neuroimaging Center Senior Researcher
2023/04 - 2024/03 National Institutes for Quantum Science and Technology Department of Functional Brain Imaging Senior Researcher
2021/04 - 2023/03 National Institutes for Quantum and Radiological Science and Technology Neural Systems and Circuits Research Group, Department of Functional Brain Imaging, Institute for Quantum Medical Science
2016/04 - 2021/03 National Institutes for Quantum and Radiological Science and Technology

Awards (1)：

2021/04 - The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Awards for Science and Technology, Research Category

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