Nagai Yuji

ナガイユウジ | Nagai Yuji

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/20415409.ja.html

Research keywords (9)： chemogenetics , 分子イメージング , PET , 獣医放射線学 , 神経科学 , 包括脳ネットワーク , 核医学(PETを含む) , ポジトロンCT , トランスレーショナルリサーチ

Research theme for competitive and other funds (7)：

2023 - 2027 化学遺伝学技術を利用した精神・神経疾患霊長類モデル動物作出技術の確立
2019 - 2022 インビボイメージングによる非ヒト霊長類脳へのDREADD技術の最適化に関する研究
2014 - 2018 Neural mechanism of cost-benefit based controlling motivation
2015 - 2017 In vivo neural projection mapping technology with a novel PET ligand
2011 - 2012 In vivo molecular neuroimaging for executive dysfunction in non-human primate model of Parkinson's disease

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Papers (75)：

Kei Oyama, Yuji Nagai, Takafumi Minamimoto. Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections. Bio-protocol. 2023. 13. 23. e4897
Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi, Mark A G Eldridge, Koki Mimura, Naohisa Miyakawa, Atsushi Fujimoto, Yuki Hori, et al. Distinct roles of monkey OFC-subcortical pathways in adaptive behavior. 2023
Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, et al. Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. EJNMMI radiopharmacy and chemistry. 2023. 8. 1. 31-31
Yuki Hori, Yuji Nagai, Yukiko Hori, Kei Oyama, Koki Mimura, Toshiyuki Hirabayashi, Ken-Ichi Inoue, Masayuki Fujinaga, Ming-Rong Zhang, Masahiko Takada, et al. Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023. 43. 39. 6619-6627
Keiichi Suzuki, Hiroko Koyama, Narumasa Nakamura, Yasuyuki Kimura, Aya Ogata, Hiroshi Ikenuma, Hideki Ishii, Ming-Rong Zhang, Kazunori Kawamura, Takafumi Minamimoto, et al. 11C-Labeling of acyclic retinoid peretinoin by rapid C-[11C]methylation to disclose novel brain permeability and central nervous system activities hidden in antitumor agent. Bioorganic & medicinal chemistry letters. 2023. 85. 129212-129212

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MISC (57)：

小野麻衣子, 高橋真奈美, 下沢明希, 藤永雅之, 森若菜, 永井裕司, 三村喬生, 熊田勝志, 下條雅文, 高堂裕平, et al. α-synuclein病変の蓄積・伝播を生体脳で可視化する分子プローブの開発. Dementia Japan. 2021. 35. 4
永井裕司, 宮川尚久, Haung Xi-Ping, Slocum Samuel T., Xiong Yan, 堀由紀子, 小山佳, 季斌, 平林敏行, 藤本淳, et al. 化学遺伝学とPETイメージングによるサル脳活動操作とモニタリング. 日本獣医麻酔外科学雑誌. 2019. 50. Suppl.2. 316-316
Oyama K, Hori Y, Nagai Y, Hirabayashi T, Miyakawa N, Fujimoto A, Mimura K, Inoue K, Eldridge A M, Saunders C R, et al. DREADD inactivation of orbitofrontal cortex revealed its critical role in reward-based adaptive decision making in monkeys. 2019
Miyakawa N, Nagai Y, Hori Y, Matsuo T, Suzuki T, Inoue K, Takada M, Suhara T, Kawasaki K, Minamimoto T. Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex. 2019
Nagai Y, Miyakawa N, Takuwa H, Hori H, Oyama K, Ji B, Takahashi M, Haung XP, Slocum ST, Xiong Y, et al. A novel ligand “deschloroclozapine” selectively visualizes and activates chemogenetic receptors in non-human primates. Brain and BrainPET 2019(パシフィコ横浜、横浜市). 2019

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Lectures and oral presentations (53)：

神経活動を選択的に制御できる人工受容体DREADDのPETイメージング
(第58回日本獣医画像診断学会 2015)
サルの報酬関連行動に影響を与える人工受容体DREADDのPETイメージング
(第30回日本大脳基底核研究会 2015)
In vivo PET imaging of the behaviorally active designer receptor in macaques
(第37回日本神経科学大会 2014)
Serotonergic dysfunction mediates decrease in motivation for instrumental action in hypothyroidism model monkeys
(8th IBRO World Congress of Neuroscience 2011)
Alteration of dopaminergic function in a primate model of hypothyroidism revealed by PET
(第34回日本神経科学大会 2011)

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Professional career (1)：

博士(獣医学) (北里大学)

Work history (4)：

2024/04 - 現在 National Institutes for Quantum Science and Technology Institute for Quantum Medical Science, Advanced Neuroimaging Center Senior Researcher
2023/04 - 2024/03 National Institutes for Quantum Science and Technology Department of Functional Brain Imaging Senior Researcher
2021/04 - 2023/03 National Institutes for Quantum and Radiological Science and Technology Neural Systems and Circuits Research Group, Department of Functional Brain Imaging, Institute for Quantum Medical Science
2016/04 - 2021/03 National Institutes for Quantum and Radiological Science and Technology

Awards (1)：

2021/04 - The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Awards for Science and Technology, Research Category

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