Rchr
J-GLOBAL ID：201401047989137934
Update date: Sep. 18, 2024
Sakaguchi Reiko
Sakaguchi Reiko
Affiliation and department：
Research field (3)：
Pharmaceuticals - chemistry and drug development
, Chemical biology
, Molecular biology
Research theme for competitive and other funds (7)：
- 2021 - 2024 トランスファーRNA修飾酵素によるタンパク質品質管理機構の解明
- 2018 - 2021 Stimuli-Responsive Synthetic Ion Channels Based on Metal-Organic Polyhedra
- 2018 - 2020 蛍光性タンパク質温度センサーを用いた生体内温度分布の意義の解明
- 2017 - 2020 Non-contact and non-invasive manipulation of biological functionalities using all-optical method
- 2016 - 2020 Regulation of cell responses by light controled signal releasing material
- 2014 - 2019 Molecular physiological studies of in vivo hypoxia niche: formation, sensing and adaptation
- 2014 - 2016 Development of fluorescent sensors to quantitatively detect signal molecules in single cells
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Papers (40)：
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Reiko Sakaguchi, Nobuaki Takahashi, Takashi Yoshida, Nozomi Ogawa, Yoshifumi Ueda, Satoshi Hamano, Kaori Yamaguchi, Seishiro Sawamura, Shinichiro Yamamoto, Yuji Hara, et al. Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals. The Journal of biological chemistry. 2024. 107705-107705
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Masayuki X. Mori, Ryo Okada, Reiko Sakaguchi, Hideharu Hase, Yuko Imai, Onur K. Polat, Satoru G. Itoh, Hisashi Okumura, Yasuo Mori, Yasushi Okamura, et al. Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP2 regulation. Scientific Reports. 2022. 12. 1
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Shunsuke Tajima, Eiji Nakata, Reiko Sakaguchi, Masayuki Saimura, Yasuo Mori, Takashi Morii. A two-step screening to optimize the signal response of an auto-fluorescent protein-based biosensor. RSC advances. 2022. 12. 24. 15407-15419
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Shin Hamada, Emmanuelle Masson, Jian-Min Chen, Reiko Sakaguchi, Vinciane Rebours, Louis Buscail, Ryotaro Matsumoto, Yu Tanaka, Kazuhiro Kikuta, Fumiya Kataoka, et al. Functionally deficient TRPV6 variants contribute to hereditary and familial chronic pancreatitis. Human mutation. 2022. 43. 2. 228-239
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Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian Ebert, Tatsuki Kurokawa, et al. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. Current biology : CB. 2020. 30. 17. 3378-3396
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MISC (18)：
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Reiko Sakaguchi, Yasuo Mori. Transient receptor potential (TRP) channels: Biosensors for redox environmental stimuli and cellular status. Free Radical Biology and Medicine. 2020. 146. 36-44
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小谷 拓史, 濱田 晋, 平野 達也, 川本 哲也, 坂口 怜子, 森 誠之, 森 泰生, 正宗 淳. TRPV6の消化器疾患発症に果たす役割に関する分子機能解析. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-202]
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小谷 拓史, 濱田 晋, 平野 達也, 川本 哲也, 坂口 怜子, 森 誠之, 森 泰生, 正宗 淳. TRPV6の消化器疾患発症に果たす役割に関する分子機能解析. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-202]
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ヘバ バドゥー, 香西大輔, 坂口怜子, 沼田朋大, 森泰生. アセトアミノフェンに誘導されるヒト肝ガン細胞死における酸化還元感受性TRPチャネルの役割. 日本薬理学会近畿部会プログラム・要旨集. 2016. 130th
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Visualization of subcellular thermal changes using fluorescent thermosensor proteins. 2015. 66. 2. 169-174
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Lectures and oral presentations (15)：
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蛍光性タンパク質温度センサーを用いた生体内温度分布の可視化とその意義の解明
(第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会 2019)
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Development of Fluorescent Tools to Visualize Intracellular Signaling
(The International Symposium of Biofunctional Chemistry 2019)
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ミトコンドリアのエネルギー産生システムの理解を目指した細胞内温度センサーの開発
(ゼロエミッションエネルギー研究拠点 平成30年度 共同利用・共同研究成果報告会 2019)
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Development of Intracellular Thermosensors for the Understanding of Energy Production in Mitochondria.
(The 9th International Symposium of Advanced Energy Science. 2018)
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TRPC5 channel-Caveolin-1- eNOS signalplexes coordinate interplay between Ca2+ and NO signals in endothelial cells.
(18th World Congress of Basic and Clinical Pharmacology. 2018)
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Work history (6)：
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