Sasaki Katsuhiro

ササキカツヒロ | Sasaki Katsuhiro

Affiliation and department：

Research field (3)： Cell biology , Immunology , Pathobiochemistry

Research keywords (4)：癌 , 免疫 , 炎症 , ユビキチン

Research theme for competitive and other funds (5)：

2020 - 2023 炎症性微小環境適応機構を標的とした抗腫瘍効果の統合的検討
2018 - 2020 T cell-induced autoinflammatory diseases
2016 - 2018 A role of anti-inflammatory T cell subset on LUBAC-deficient autoinflammatory diseases
2011 - 2013 胸腺特異的タンパク質分解メカニズムによる免疫制御機構の解明
2008 - 2010 胸腺プロテアソームによる免疫制御機構の解明

Papers (20)：

Katsuhiro Sasaki, Yoshie Hayamizu, Ryuji Murakami, Masakazu Toi, Kazuhiro Iwai. Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion. FEBS Letters. 2023
Yusuke Sakamoto, Katsuhiro Sasaki, Mayuki Omatsu, Kensuke Hamada, Yuki Nakanishi, Yoshiro Itatani, Kenji Kawada, Kazutaka Obama, Hiroshi Seno, Kazuhiro Iwai. Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation. The Journal of Pathology. 2022. 259. 3. 304-317
Koji Jimbo, Ayuna Hattori, Shuhei Koide, Takahiro Ito, Katsuhiro Sasaki, Kazuhiro Iwai, Yasuhito Nannya, Atsushi Iwama, Arinobu Tojo, Takaaki Konuma. Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia. Leukemia. 2022. 37. 1. 122-133
Katsuhiro Sasaki, Kazuhiro Iwai. Role of linear ubiquitination in inflammatory responses and tissue homeostasis. International Immunology. 2022
Yutaka Shinkawa, Koshi Imami, Yasuhiro Fuseya, Katsuhiro Sasaki, Koichiro Ohmura, Yasushi Ishihama, Akio Morinobu, Kazuhiro Iwai. ABIN1 is a signal-induced autophagy receptor that attenuates NF-κB activation by recognizing linear ubiquitin chains. FEBS letters. 2022. 596. 9. 1147-1164

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MISC (1)：

Koji Jimbo, Shuhei Koide, Takahiro Ito, Arinobu Tojo, Katsuhiro Sasaki, Kazuhiro Iwai, Atsushi Iwama, Yasuhito Nannya, Takaaki Konuma. Deficiency of the E3 Ligase Hoip Impairs Adult Hematopoiesis and Myeloid Leukemia. BLOOD. 2021. 138

Books (3)：

創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術 --自己免疫疾患のTRを成功に導く発症・病態メカニズムのモデル化
技術情報協会 2021 ISBN:9784861048562
生化学 --直鎖状ユビキチン鎖を生成するLUBACリガーゼの構造,機能,T細胞機能制御
東京化学同人・日本生化学会 2020
医学のあゆみ --多様化するユビキチンコード
医歯薬出版 2018

Lectures and oral presentations (12)：

Cancer, inflammation, and polyubiquitin signaling
(2023)
直鎖状ユビキチン鎖シグナルが創り出す病的・恒常的炎症環境
(第95回日本生化学会 2022)
癌進展を加速させる炎症駆動型直鎖状ユビキチン修飾機構
(第94回日本生化学会 2021)
直鎖状ユビキチン鎖生成酵素LUBACによる免疫制御と組織恒常性維持
(第42回日本分子生物学会年会)
An autoinflammatory mechanism by TNFalpha-expressing T cells
(17th TNF conference 2019 2019)

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Professional career (1)：

Awards (6)：

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Association Membership(s) (3)：

日本免疫学会 , The Molecular Biology Society of Japan , The Japanese Biochemical Society

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