2018 - 2021 Development of periodontal tissue regenerative therapy by using neural crest-derived MSCs and cell clumps culture technique
2016 - 2019 Development of a xeno-free induction and maintenance protocol for MSCs from PSCs
2016 - 2018 Identification of the cell-of-origin of ectopic bones using lineage tracing mice
2016 - 2018 Induction of tendon/ligament progenitor cells from human iPSCs
2015 - 2018 Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment
2015 - 2017 Functional analyses of mutant NLRP3 on the growth and differentiation of growth plate chondrocytes
2015 - 2017 Induction of corneal endothelial like cells from human pluripotent stem cells through derived neural crest cells.
2014 - 2016 Derivation of human PSC-derived mesodermal cells
2013 - 2016 Analysis of fibrodysplasia ossificans progressive by using iPSCs
2012 - 2015 Investigation for the pathomechanism of cartilage-forming tumors by whole exome sequencing
2012 - 2014 Establishment of canine iPS cells for the study of disease-model dogs
2011 - 2012 Establishment of the assay system of drug screening for fibrodysplasia ossificans progressiva
2009 - 2010 Functional analysis of BMP binding protein, Cv2, in nephorogenesis
1998 - 2000 背側神経管で発現するWnt遺伝子(Wnt-1及びWnt-3a)の機能解析
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Papers (85)：
Pan Gao, Mikihito Kajiya, Souta Motoike, Makoto Ikeya, Jingmei Yang. Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges. The Japanese dental science review. 2024. 60. 95-108
Megumi Yokomizo-Goto, Nana Takenaka-Ninagawa, Chengzhu Zhao, Clémence Kiho Bourgeois Yoshioka, Mayuho Miki, Souta Motoike, Yoshiko Inada, Denise Zujur, William Theoputra, Yonghui Jin, et al. Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice. Stem cell research & therapy. 2024. 15. 1. 340-340
Pan Gao, Yoshiko Inada, Akitsu Hotta, Hidetoshi Sakurai, Makoto Ikeya. iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva. Stem cell research & therapy. 2024. 15. 1. 83-83
Ziadoon Al-Akashi, Denise Zujur, Daisuke Kamiya, Tomohisa Kato, Toru Kondo, Makoto Ikeya. Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification. Frontiers in Cell and Developmental Biology. 2023. 11
Keisuke Mizuno, Hiroe Ohnishi, Masayoshi Yoshimatsu, Chengzhu Zhao, Yasuyuki Hayashi, Fumihiko Kuwata, Shinji Kaba, Hideaki Okuyama, Yoshitaka Kawai, Nao Hiwatashi, et al. Laryngeal Cartilage Regeneration of Nude Rats by Transplantation of Mesenchymal Stem Cells Derived from Human-Induced Pluripotent Stem Cells. Cell Transplantation. 2023. 32. 096368972311784-096368972311784
