Hirayasu Kouyuki

ヒラヤスコウユキ | Hirayasu Kouyuki

Affiliation and department：

Research field (3)： Bacteriology , Medical biochemistry , Immunology

Research keywords (11)： LILR , マラリア , 抑制化レセプター , 感染症 , 病原体 , 遺伝子多型 , 細菌 , KIR , 自然選択 , NK細胞 , 活性化レセプター

Research theme for competitive and other funds (6)：

2019 - 2022 Host-bacteria interactions through immune evasion mechanism
2019 - 2021 Immune evasion mechanism of tumors mediated by NK cell receptors
2016 - 2019 The role of immune receptors with inter- and intraspecies diversity in infectious diseases
2015 - 2018 New mechanism of autoimmune diseases mediated by misfolded protein/MHC class II complex
2015 - 2017 Studies on new host-pathogen interaction via bacterial protease

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Papers (30)：

Kouyuki Hirayasu, Seik-Soon Khor, Yosuke Kawai, Mihoko Shimada, Yosuke Omae, Gen Hasegawa, Yuko Hashikawa, Hiromu Tanimoto, Jun Ohashi, Kazuyoshi Hosomichi, et al. Identification of the hybrid gene LILRB5-3 by long-read sequencing and implication of its novel signalling function. Frontiers in Immunology. in press. 2024
Wang Jiaqi, Furukawa Atsushi, Yamazaki Rika, Hirayasu Kouyuki, Kadomatsu Tsuyoshi, Oike Yuichi, Arase Hisashi, Maenaka Katsumi. 免疫受容体LILRA2のANGPTL6認識機構(Molecular mechanism of ANGPTL6 recognition by immune activation receptor LILRA2). 生物物理. 2022. 62. Suppl.1-2. S269-S269
Mei-Tzu Su, Masanori Inui, Yi Li Wong, Maika Takahashi, Akiko Sugahara-Tobinai, Karin Ono, Shotaro Miyamoto, Keiichi Murakami, Ari Itoh-Nakadai, Dai Kezuka, et al. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. International immunology. 2021. 33. 8. 447-458
Kouyuki Hirayasu, Jinwen Sun, Gen Hasegawa, Yuko Hashikawa, Kazuyoshi Hosomichi, Atsushi Tajima, Katsushi Tokunaga, Jun Ohashi, Rikinari Hanayama. Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population. Journal of human genetics. 2021. 66. 7. 739-748
Akihito Sakoguchi, Fumiji Saito, Kouyuki Hirayasu, Kyoko Shida, Sumiko Matsuoka, Sawako Itagaki, Wataru Nakai, Masako Kohyama, Tadahiro Suenaga, Shiroh Iwanaga, et al. Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2. Biochemical and biophysical research communications. 2021. 548. 167-173

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MISC (25)：

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Books (16)：

LILRファミリーの歴史と展望
炎症と免疫 (先端医学社) 31:503-507 2023
LILRファミリーの多様性と疾患
炎症と免疫 (先端医学社) 30:400-404 2022
抑制化レセプターによるマクロファージの機能制御
シン・マクロファージ(羊土社) 2022
デジタルPCRによる免疫受容体のコピー数多型解析
実験医学別冊リアルタイム・デジタルPCR実験スタンダード (羊土社) 2022
LILRファミリーを標的とした病原体および腫瘍の免疫逃避機構
臨床免疫・アレルギー科 71(3), 283-287 (科学評論社) 2019

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Lectures and oral presentations (48)：

細菌はいかにして宿主からの攻撃を回避するのか?
(岡山大学医学部医学科「細菌学」特別講義 2023)
ヒト特有な免疫レセプター群にみる赤の女王仮説の例
(都医学研セミナー 2022)
免疫レセプターLILRの多様性とデジタルPCRの活用例
(QIAGEN デジタルPCR ユーザー講演 2022)
Genetic diversity of immune receptors LILRB3 and LILRA6 suggests their interaction with bacteria
(The 50th Annual Meeting of The Japanese Society for Immunology 2021)
LILRファミリーを介した宿主微生物相互作用
(第21回日本アデノウイルス研究会 2021)

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Education (2)：

- 2009 The University of Tokyo Graduate School of Medicine International Health
- 2004 The University of Tokyo Faculty of Medicine School of Health Sciences and Nursing

Professional career (1)：

博士(保健学) (東京大学)

Work history (6)：

2023/04 - 現在金沢大学先進予防医学研究科免疫進化学分野主任
2022/04 - 現在 Kanazawa University
2018/01 - 2022/03 Kanazawa University
2012/04 - 2017/12 Osaka University WPI Immunology Frontier Research Center
2010/04 - 2012/03 Osaka University WPI Immunology Frontier Research Center

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Committee career (2)：

2023/10 - 現在日本細菌学会中部支部評議員
2021/11 - 現在 Editorial Board of Immunogenetics (specialty section of Frontiers in Genetics) Review Editor

Awards (7)：

2023/09 - 学術変革領域研究(A)「自己指向性免疫学」ベストプレゼンテーション賞
2019/04 - 文部科学大臣表彰若手科学者賞
2018/05 - 第9回ライフサイエンス研究交流セミナー最優秀ポスター賞
2017/12 - The Japanese Society for Immunology JSI Young Investigator Award
2017/02 - 第45回日本免疫学会学術集会ベストプレゼンテーション賞

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Association Membership(s) (4)：

JAPANESE SOCIETY FOR BACTERIOLOGY , JAPANESE SOCIETY FOR HISTOCOMPATIBILITY AND IMMUNOGENETICS , THE JAPANESE SOCIETY FOR IMMUNOLOGY , 日本人類遺伝学会

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