Itoh Katsuhiko

Affiliation and department：

Research field (1)： Pathobiochemistry

Research theme for competitive and other funds (29)：

2016 - 2019 The role of HSP110 family, Apg-2 in NASH-related hepatic lipid and glucose metabolism.
2015 - 2018 The role of Apg-2 in liver steatosis and carcinogenesis
2011 - 2013 Direct reprogramming of fibroblasts to hemetopoietic stem cells
2006 - 2007 PI3キナーゼ経路調節分子群の発現制御異常の分子機構
2005 - 2006 B型肝炎ウイルスのコードするmicroRNAの検索

2005 - 2006 消化管上皮の初代培養細胞を不死化させる技法の開発

2004 - 2005 Regulatory mechanisms of gene expression at mildly low temperature and the clinical relevance of their abnormality in the testis.

2003 - 2004 HCV core蛋白を標的とした新たな遺伝子治療戦略の可能性

2002 - 2003 Studies on the trans-differentiation of hematopoietic stem cells and the application for the gene therapy

2002 - 2003 Molecular mechanism of proliteration and differentistion of male germ cells analyzed by using the cell line that undergoes "meiosis"in vitro.

2001 - 2002 Gene transfer to hematopoietic stem cells by a newly-designed retroviral vectors and expression of transgenes in the liver

2001 - 2001 がん抑制遺伝子のタンパク分解に関与するがん遺伝子ガンキリンの機能解析

2000 - 2001 Studies on the effects of heat shock proteins of the HSP110 family on the aggregation of poly-glutamine

2000 - 2001 On the transgene expression mediated by retrouival vectors

2000 - 2000 ガンキリンを標的とした肝細胞がん治療法の開発

2000 - 2000 FMEVタイプのレトロウイルス・ベクターの転写制御領域の解析

1999 - 2000 肝細胞で高発現する新しいレトロウイルスベクターの開発

1999 - 2000 Development of novel packaging cells for refrovirus vectors based on stromal cells

1999 - 2000 Functions and clinical significance of cold shock proteins in the testis

1999 - 1999 分子シャペロンAPG-1とAPG-2の生体における機能の解析

1998 - 1999 Development of a method for efficient transfer and expression of genes in hematopoietic cells.

1998 - 1998 ストローマ依存性の多能性幹細胞株の自己複製機構の解析

1998 - 1998 HSP105/110群に属するAPG-1とAPG-2の機能解析

1998 - 1998 RNA結合蛋白CIRPによる細胞増殖の抑制機序と臨床的意義

1997 - 1998 哺乳類細胞における低温ストレス応答の解析

1997 - 1998 Development of a novel retrovirus vector system for hematopoietic Stem cells

1997 - 1998 Temperature sensitive gene expression in male germ cells and its clinical signification

1997 - 1997 HSP105/110群に属する新しい遺伝子apg-1とapg-2の機能解析

1996 - 1996 造血幹細胞を標的とした新たなレトロウイルスベクター系の作成

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Papers (86)：

Itoh K, Kondoh G, Miyachi H, Sugai M, Kaneko Y, Kitano S, Watanabe H, Maeda R, Imura A, Liu Y, et al. Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo. Sci Signal. 2019. 12. 574. 10.1126/scisignal.aao7232
Fujita T, Liu Y, Higashitsuji H, Itoh K, Shibasaki K, Fujita J, Nishiyama H. Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. Biochem Biophys Res Commun. 2018. 495. 1. 935-940
Takanori Fujita, Hiroaki Higashitsuji, Hisako Higashitsuji, Yu Liu, Katsuhiko Itoh, Toshiharu Sakurai, Takahiro Kojima, Shuya Kandori, Hiroyuki Nishiyama, Motoi Fukumoto, et al. TRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3. SCIENTIFIC REPORTS. 2017. 7. 2295
Toshiharu Sakurai, Hiroaki Higashitsuji, Hiroshi Kashida, Tomohiro Watanabe, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Masayuki Kitano, Naoshi Nishida, Takaya Abe, et al. The oncoprotein gankyrin promotes the development of colitis-associated cancer through activation of STAT3. ONCOTARGET. 2017. 8. 15. 24762-24776
蒋景眞, 眞野浩人, Aoki Koji, 林達成, 武藤哲彦, 南部由希子, Takahashi Katsu, Itoh Katsuhiko, Taketani Shigeru, Nutt Stephen L., et al. ミトコンドリアによる活性化B細胞運命決定機構の解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P1350]-[1P1350]

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MISC (6)：

南部由希子, 林達成, JANG Kyoung-Jin, 青木耕史, 真野浩人, 中野圭子, 大里元美, 高橋克, 伊藤克彦, 手良向聡, et al. CD4T細胞は末梢にてCD8ααT細胞に再分化する. 日本分子生物学会年会プログラム・要旨集(Web). 2012. 35th. 4P-0456 (WEB ONLY)
伊藤克彦, 増田智子, 山口寛二, 藤田潤. マーカー遺伝子を導入し,生体内で濃縮された造血(幹)細胞は,肝細胞へ分化転換しなかった. 日本血液学会・日本臨床血液学会総会プログラム・抄録集. 2005. 67回・47回. 807-807
藤田潤, 伊藤克彦, 小杉眞司, 依藤亨, 藤村聡, 富和清隆. 「いでんネット」へのメールから見える遺伝医療の現状. 日本遺伝カウンセリング学会誌. 2005. 26. 1. 40-40
K Yamaguchi, Y Itoh, N Ohnishi, T Okanoue, K Itoh, J Fujita. LTRs in a retrovirus vector equipped with the sequence from HBV enhancer II demonstrate higher and hepatocyte-specific expression of trangenes in vitro and in vivo. HEPATOLOGY. 2003. 38. 4. 590A-590A
N Ohnishi, Y Itoh, K Yamaguchi, T Okanoue, K Itoh, J Fujita. Efficient expression of trunsduced genes by a novel hybrid retrovirus vector in hepatocytes are regulated by two elements in the upstream control region of the SFFVp LTR. HEPATOLOGY. 2001. 34. 4. 379A-379A

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Lectures and oral presentations (2)：

Interaction of cold-inducible RNA-binding protein with Dyrk1b regulates early spermatogenesis.
(2011)
Regulation of spermatogenesis by a cold inducible protein, CIRP.
(Mechanisms of early differentiation: embryogenesis, myogenesis (cardiac differentiation) and hematopoiesis/lymphopoiesis. 2008)

Professional career (1)：

医学博士 (京都大学)

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