Research keywords (5)：
Molecular biology of the inner ear function
, Regenerative medicine of the inner ear
, Development of the inner ear
, Cochlear implantation
, Otology and Neurotology
Research theme for competitive and other funds (34)：
2024 - 2027 Analysis of the mechanism of cochlear planar polarity formation by spatial transcriptome analysis
2023 - 2026 Mechanisms of supporting cell reprogramming for inducing hair cell regeneration in chick basilar papillae
2022 - 2025 Elucidation of Inner Ear Development Mechanisms using multi-omics
2022 - 2025 Diversity and Alteration of the phenotype of cochlear resident macrophates during development
2021 - 2024 Elucidation of the cochlear development and inner ear pathology with imaging mass-spectrometry for the treatment of sensorineural hearing loss
2018 - 2021 Mechanism of cochlear hair cell damage due to homeostatic disruption
2017 - 2021 Development of a new treatment method for hearing loss by fusing cochlear implant technology and cochlear nerve regeneration
2017 - 2021 Roles of IGF-1-Netrin axis in the cochlea
2016 - 2020 Csf1r signaling plays a key role on origin and differentiation of resident macrophages in the developing cochlea
2015 - 2018 Cochlear supporting cells as a target of cochlear pathology and regenerative medicine
2014 - 2018 Histopathological evaluation using optical coherence tomography in the head and neck region
2014 - 2017 Roles of IGF1 signaling in age-related hearing impairment
2013 - 2016 Auditory processing with bilateral cochlear implantation in patients with pervasive developmental disorder
2013 - 2016 Identification of causative genetic locus of a large family with hearing loss
2011 - 2016 Elucidation of inner ear development mechanisms and its application to regenerative medicine
2013 - 2015 Assisting system for surgical and examination endoscopy using virtual reality with internal information obtained by OCT
2012 - 2015 Tranlational research for the improved outcome and the broader indication of the cochlear implantation
2012 - 2014 Development of a new device mimicking the vestibular epithelium using piezoelectric materials
2011 - 2013 ヒト多能性幹細胞から有毛細胞分化誘導の高効率化
2011 - 2012 Induction of inner ear tissue by stem cell injection into the inner ear deficient mouse embryos
2011 - 2012 Visualization of regenerated auditory nerves via cell transplantation
2010 - 2012 A novel method for analyzing inner ear disorders using disease-specific iPS cells
2010 - 2011 Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration
2008 - 2010 Development of the regeneration method for inner ear disorders -Applying molecular mechanisms of inner ear development-
2005 - 2006 Wnt signaling activation for regeneration of inner ear hair cell
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Papers (154)：
Shintaro Otsuka, Chihiro Morimoto, Shin-ya Nishio, Shinya Morita, Daisuke Kikuchi, Masahiro Takahashi, Kozo Kumakawa, Yasuhiro Arai, Hajime Sano, Hidekane Yoshimura, et al. The Heterozygous p.A684V Variant in the WFS1 Gene Is a Mutational Hotspot Causing a Severe Hearing Loss Phenotype. Genes. 2025
Hiroshi Yamazaki, Saburo Moroto, Tomoko Yamazaki, Rinko Tamaya, Naoko Fujii, Keizo Fujiwara, Norio Yamamoto, Yasushi Naito. Significant influence of prelingual deafness but less impact of elderly age at implantation on long-term psychoacoustic CI programming parameters. Auris Nasus Larynx. 2024
Masayuki Kitano, Hiroe Ohnishi, Akiko Makino, Tatsuo Miyamoto, Yasuyuki Hayashi, Keisuke Mizuno, Shinji Kaba, Yoshitaka Kawai, Tsuyoshi Kojima, Yo Kishimoto, et al. An infection model for SARS-CoV-2 using rat transplanted with hiPSC-airway epithelial cells. Tissue engineering. Part A. 2024
Hiroki Kagoshima, Hiroe Ohnishi, Ryosuke Yamamoto, Akiyoshi Yasumoto, Yosuke Tona, Takayuki Nakagawa, Koichi Omori, Norio Yamamoto. EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development. The Journal of Neuroscience. 2024. 44. 7. e1060232023-e1060232023
