Yamamoto Norio

Affiliation and department：

Research field (1)： Otorhinolaryngology

Research keywords (5)： Molecular biology of the inner ear function , Regenerative medicine of the inner ear , Development of the inner ear , Cochlear implantation , Otology and Neurotology

Research theme for competitive and other funds (33)：

2023 - 2026 Mechanisms of supporting cell reprogramming for inducing hair cell regeneration in chick basilar papillae
2022 - 2025 Elucidation of Inner Ear Development Mechanisms using multi-omics
2022 - 2025 Diversity and Alteration of the phenotype of cochlear resident macrophates during development
2022 - 2025 アブミ骨筋反射の可視化とAIを組み合わせた顔面神経麻痺の早期予後診断法の開発
2022 - 2025 Off-frequencyノイズオージオメトリによる聴覚求心路障害診断法の開発

2021 - 2024 Elucidation of the cochlear development and inner ear pathology with imaging mass-spectrometry for the treatment of sensorineural hearing loss

2021 - 2024 内耳蝸牛三次元構造形成メカニズムの解明と蝸牛型オルガノイド作製への応用

2021 - 2023 CRISPR/Cas系による新型コロナウイルス感染と気道上皮バリア破壊機構の解明

2020 - 2023 Mechanisms for the initial process of hair cell regeneration in avian inner ears

2019 - 2022 Elucidation of the develpmental mechanism of the cochlear sensory epithelia based on the single cell analysis

2019 - 2022 The role of cochlear resident macrophages in age-related hearing loss

2018 - 2021 Function of long non-coding RNA in the development and regeneration of inner ears

2018 - 2021 蝸牛・前庭感覚上皮発生機序の解析とヒトiPS細胞を用いた難聴モデル作製への応用

2018 - 2021 Mechanism of cochlear hair cell damage due to homeostatic disruption

2017 - 2021 Development of a new treatment method for hearing loss by fusing cochlear implant technology and cochlear nerve regeneration

2017 - 2021 Roles of IGF-1-Netrin axis in the cochlea

2016 - 2020 Csf1r signaling plays a key role on origin and differentiation of resident macrophages in the developing cochlea

2015 - 2018 Cochlear supporting cells as a target of cochlear pathology and regenerative medicine

2014 - 2018 Histopathological evaluation using optical coherence tomography in the head and neck region

2014 - 2017 Roles of IGF1 signaling in age-related hearing impairment

2013 - 2016 Auditory processing with bilateral cochlear implantation in patients with pervasive developmental disorder

2013 - 2016 Identification of causative genetic locus of a large family with hearing loss

2011 - 2016 Elucidation of inner ear development mechanisms and its application to regenerative medicine

2013 - 2015 Assisting system for surgical and examination endoscopy using virtual reality with internal information obtained by OCT

2012 - 2015 Tranlational research for the improved outcome and the broader indication of the cochlear implantation

2012 - 2014 Development of a new device mimicking the vestibular epithelium using piezoelectric materials

2011 - 2013 ヒト多能性幹細胞から有毛細胞分化誘導の高効率化

2011 - 2012 Induction of inner ear tissue by stem cell injection into the inner ear deficient mouse embryos

2011 - 2012 Visualization of regenerated auditory nerves via cell transplantation

2010 - 2012 A novel method for analyzing inner ear disorders using disease-specific iPS cells

2010 - 2011 Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration

2008 - 2010 Development of the regeneration method for inner ear disorders -Applying molecular mechanisms of inner ear development-

2005 - 2006 Wnt signaling activation for regeneration of inner ear hair cell

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Papers (145)：

山本典生, 十名洋介, 岡野高之, 大森孝一. 術中移動式コーンビームCT支援下のcommon cavity deformity症例に対する人工内耳電極挿入. 日本耳科学会総会・学術講演会抄録集. 2023. 33回. 131-131
Yuji Kitada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Masayuki Kitano, Keisuke Mizuno, Koichi Omori. Transplantation of Induced Pluripotent Stem Cell-Derived Airway Epithelia with a Collagen Scaffold into the Nasal Cavity. Tissue Engineering Part C: Methods. 2023. 29. 11. 526-534
楯谷智子, 岡野高之, 西村幸司, 暁久美子, 吉澤亮, 山崎博司, 濱口清海, 扇田秀章, 田浦晶子, 山本典生, et al. めまいを主訴とする初診患者の外来診療実態調査. Equilibrium Research. 2023. 82. 5. 498-498
Naoe Mori, Norio Yamamoto, Shinobu Yamaguchi, Kanako Kondo, Misaki Yoshizawa, Takayuki Okano, Juichi Ito, Koichi Omori. Long-term effects of second cochlear implantation with sequential bilateral cochlear implantation in Japanese children. Auris, nasus, larynx. 2023
Taishi Inoue, Yosuke Tona, Takayuki Okano, Koichi Omori, Norio Yamamoto. Detection of Tip Fold-Over of the Slim Modiolar Electrode Using Intraoperative Mobile Cone-Beam Computed Tomography. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 2023. 169. 1. 105-111

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MISC (284)：

井上大志, 山本典生, 岡野高之, 十名洋介, 大森孝一. Slim modiolar電極のtip fold-overを術中コーンビームCTで指摘しえた2症例. 日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集. 2022. 31st
山本典生. 【みみ・はな・のどの外来診療update-知っておきたい達人のコツ26-】鼓膜穿孔への対処法. ENTONI. 2021. 257. 19-26
山本典生. 【難聴の治療-再生医療から人工聴覚器まで】IGF-1による急性感音難聴の治療. 医学のあゆみ. 2021. 276. 7. 689-694
松永麻美, 山本亮介, 山本典生, 岡野高之, 大森孝一, 中川隆之. 鳥類蝸牛有毛細胞再生初期過程における支持細胞活性化機構の探索. 日本耳鼻咽喉科学会会報. 2021. 124. 4
吉澤美咲, 山本典生, 森尚彫, 森尚彫, 近藤香菜子, 井口奈美江, 小林泰輔, 十河ゆかり, 土居奈央, 岡野高之, et al. オンライン会議システムを用いて遠隔診療施設と共同でマッピングを行った人工内耳小児例. Audiology Japan. 2021. 64. 5

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Patents (1)：

内耳の有毛細胞を誘導するための医薬

Books (13)：

標準耳鼻咽喉科・頭頸部外科学
医学書院 2022 ISBN:9784260047654
今日の治療指針 : 私はこう治療している
医学書院 2022 ISBN:9784260047760
【みみ・はな・のどの外来診療update-知っておきたい達人のコツ26-】
全日本病院出版会 2021
内科医が知っておくべき疾患102 : 各科スペシャリストが伝授
中山書店 2020 ISBN:9784521748054
今日の治療指針 2020年版
医学書院 2020

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Lectures and oral presentations (132)：

よくわかる人工内耳医療 -小児から高齢者まで-
(京都大学耳鼻咽喉科・頭頸部外科市民公開講座ー補聴器でも聞き取りにくい方へー 2021)
最近の人工内耳の話題
(第2回聴覚補償研究会 2021)
シンポジウム2 Digital Transformation(DX)時代の耳鼻咽喉科医療音声認識技術を用いた聴覚障害者支援
(第122回日本耳鼻咽喉科学会学術総会・講演会 2021)
スタンダードな治療をめざした鼓膜再生療法の実際 -これから鼓膜再生治療を始めたい先生方のために- 症例報告2
(第82回耳鼻咽喉科臨床学会総会・学術講演会 2020)
人工内耳機器の最新トピック人工内耳パネルディスカッション:新製品Slim Modiolar電極-使用経験と電極選択 Placement
(第30回日本耳科学会総会・学術講演会 2020)

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