Rchr
J-GLOBAL ID:201401071382419483   Update date: Sep. 19, 2024

Kobayashi Minoru

Kobayashi Minoru
Affiliation and department:
Research field  (1): Cell biology
Research theme for competitive and other funds  (12):
  • 2021 - 2024 がん個別化放射線治療法の確立に向けたTR研究
  • 2021 - 2024 新規リアルタイムDNA損傷修復応答検出システムの構築と腫瘍内DNA損傷応答の解析
  • 2021 - 2023 悪性固形腫瘍内低酸素がん細胞に対する血中マーカーのゲノムワイドスクリーニング
  • 2019 - 2021 A novel invasion-related gene involved in tumor recurrence after radiation therapy
  • 2018 - 2021 Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers
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Papers (39):
  • Gouki Kambe, Minoru Kobayashi, Hiroshi Ishikita, Sho Koyasu, Ester M. Hammond, Hiroshi Harada. ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1. Biochemical and Biophysical Research Communications. 2024. 733. 150604-150604
  • Huiying Mu, Shuai Shao, Bingquan Wu, Koji Miki, Minoru Kobayashi, Hiroshi Harada, Kouichi Ohe. Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance. Sensors and Actuators B: Chemical. 2024. 413. 135876-135876
  • Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shimpei I. Kubota, Hiroyuki Yatabe, et al. Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging. Science Advances. 2024. 10. 29
  • Lee PWT, Suwa T, Kobayashi M, Yang H, Koseki LR, Takeuchi S, Chow CCT, Takaaki Yasuhara, Hiroshi Harada. Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner. British journal of cancer. 2024
  • Peter W.T. LEE, Lina Rochelle Koseki, Takao Haitani, Hiroshi Harada, Minoru Kobayashi. Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells. Cancers. 2024
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MISC (9):
  • 小林 稔, 平岡, 真寛, 原田 浩. 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析. 2014
  • Minoru Kobayashi, Hiroshi Harada. [Hypoxic stress and HIF]. Seikagaku. The Journal of Japanese Biochemical Society. 2013. 85. 3. 187-195
  • 小林 稔, 曽 麗華, 後藤 容子, 井上 実, 板坂 聡, 吉村 通央, 原田 浩, 平岡 真寛. IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する. 2013
  • Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells. 2013
  • KOBAYASHI Minoru, ASHINO Shigeru, SUZUKI Ikurou, KITAMURA Hidemitsu, YASUDA Kenji, NISHIMURA Takashi. Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation. 2011
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Lectures and oral presentations  (22):
  • Decreased expression levels of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase
    (第18回がんとハイポキシア研究会 2022)
  • DNA double strand breaksのインビボ定量評価に向けたEGFP-53BP1ノックインマウスの樹立
    (2019)
  • A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes
    (2018)
  • HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating Shh.
    (2018)
  • A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes
    (The 17th International Joint Mini-Symposium on Molecular and Cell Biology 2018)
more...
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