Kuwahara Koichiro

クワハラコウイチロウ | Kuwahara Koichiro

Affiliation and department：
Other affiliations (1)：

京都大学非常勤講師

Research field (5)： Cardiology , Internal medicine - General , Metabolism and endocrinology , Genomics , Molecular biology

Research keywords (11)：循環器内科学 , 心不全 , ナトリウム利尿ペプチド , 細胞・再生治療 , 重症心不全 , iPS細胞 , 心血管代謝内分泌学 , エピゲノム制御 , シグナル伝達 , 遺伝子転写制御 , 地域医療・医療連携

Research theme for competitive and other funds (32)：

2022 - 2025 心不全におけるBNP、ANP前駆体の分泌調節不全の機序解明と新規治療法の開発
2022 - 2025 肺動脈性肺高血圧症におけるTRPC6, CNP経路の研究
2021 - 2024 Elucidation of significance of saliva PRPs as a potential biomarker and therapeutic target for aging-associated cardiovascular and renal diseases
2021 - 2024 肺動脈性肺高血圧症に対する治療薬としての TRPC3/6阻害薬L862の有効性についての治験準備
2020 - 2023 Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets

2019 - 2022 Development of novel diagnostic and therapeutic methods for cardiac diseases based on the elucidation of the regulatory mechanism of glycosylation of proBNP

2018 - 2021 Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertension

2017 - 2020 Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function

2017 - 2020 Long term follow-up of cardiac function and prognosis after optimal therapy in patients with systemic amyloidosis

2018 - 2020 高齢心不全患者の多剤併用および薬剤性有害事象に関する診療実態調査

2016 - 2019 Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation

2016 - 2018 Investigation of the significance of MRTF-A, a co-activator of SRF, in the development of obesity that is an underlying risk factor for cardiovascular diseases

2015 - 2018 Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial Hypertension

2015 - 2018 Elucidation of the molecular mechanism and clinical application of increased plasma level of BNP precursor in patients with heart failure

2014 - 2017 Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism

2014 - 2017 Impact of exercise therapy on oxidative stress in patients with peripheral artery disease

2014 - 2016 Elucidation of significance of vascular CNP-GC-B system in vascular integrity and pathology

2013 - 2016 Elucidation of pathophysiological significance of glycosylation in the regulatory mechanism of BNP processing

2012 - 2016 HCN4-luciferase knock-in mouse is a new tool for pacemaker cell reprogramming

2012 - 2015 Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling

2012 - 2014 Significance of reciprocal expression of myocardian and MRTF-A during the development of vascular disease

2011 - 2014 Elucidation of transcriptional and epigenomic regulation in the development of heart failure

2009 - 2014 Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

2012 - 2014 新規創薬を目指した生活習慣病・難治性疾患モデル遺伝子変異ラットの開発と解析

2011 - 2013 Translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin

2011 - 2012 新規カルシウムチャネルTRPC3/6イオンチャネルを標的とした新規心血管病治療薬の開発

2010 - 2012 Elucidation of significance of TRPM2 in progression of heart failure

2009 - 2011 新規遺伝子変異ラット作製技術に基づく生活習慣病・難治性疾患モデルラットの開発

2008 - 2010 Elucidation of molecular mechanisms regulating the gene expression of fetal cardiac ion channels and its implication as a novel therapeutic target for the treatment of heart failure

2007 - 2008 Crosstalk between NRSF-NRSE system and PPAR system contributing to the homeostasis of cardiac myocyte function

2006 - 2006 ヒストンアセチル化酵素の心筋ミトコンドリア形成と細胞生存維持における役割の解明

2000 - 2002 心筋細胞の最終分化に関わる転写調節機構の解明

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Papers (267)：

Hideki Kobayashi, Shugo Tohyama, Hajime Ichimura, Noburo Ohashi, Shuji Chino, Yusuke Soma, Hidenori Tani, Yuki Tanaka, Xiao Yang, Naoko Shiba, et al. Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids. Circulation. 2024
Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, et al. Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin. Stem cell research & therapy. 2023. 14. 1. 240-240
Nishikawa R, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Yamamoto E, Ozasa N, Tada T, Sakamoto H, et al. The characteristics and outcomes in patients with acute heart failure who used tolvaptan: from KCHF registry. ESC Heart Fail. 2023
Shun-Ichi Wakabayashi, Satoru Joshita, Kazuhiro Kimura, Hirohiko Motoki, Taiki Okumura, Hiroyuki Kobayashi, Yuki Yamashita, Ayumi Sugiura, Tomoo Yamazaki, Takefumi Kimura, et al. Symptom-based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease. JGH open : an open access journal of gastroenterology and hepatology. 2023. 7. 8. 527-536
Kanai M, Minamisawa M, Motoki H, Seko Y, Kimura K, Okano T, Ueki Y, Yoshie K, Kato T, Saigusa T, et al. Prognostic Impact of Hyperpolypharmacy Due to Noncardiovascular Medications in Patients After Acute Decompensated Heart Failure - Insights From the Clue of Risk Stratification in the Elderly Patients With Heart Failure (CURE-HF) Registry. Circ J. 2023

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MISC (202)：

Hidenori Yaku, Takao Kato, Takeshi Morimoto, Yasutaka Inuzuka, Yodo Tamaki, Erika Yamamoto, Yusuke Yoshikawa, Neiko Ozasa, Koichiro Kuwahara, Takeshi Kimura. Association of Mineralocorticoid Receptor Antagonist by Hospitalized Patients With Heart Failure With Preserved Ejection Fraction With Outcomes After Discharge. 第23回日本心不全学会. 2019
中川靖章, 錦見俊雄, 酒井宏, 大野聖子, 木下秀之, 稲住英明, 森内健史, 柳澤洋, 桑原宏一郎, 堀江稔, et al. BNP異常高値の原因がmacro-proBNP血症であった症例. 日本内分泌学会雑誌. 2018. 94. 1. 347-347
趙晃済, 桑原宏一郎, 錦見俊雄, 中川靖章, 木下秀之, 南丈也, 稲住英明, 森内健史, 大矢未来, 南野直人, et al. アドレノメデュリンは加齢や肥満に伴う高血圧を抑制する. Anti-aging Science. 2017. 9. 2. 100-100
中川靖章, 錦見俊雄, 酒井宏, 大野聖子, 木下秀之, 稲住英明, 森内健史, 桑原宏一郎, 堀江稔, 木村剛. マクロproBNP血症の一例. 日本内分泌学会雑誌. 2017. 93. 4. 1392-1392
Tamon Kato, Yusuke Miyashita, Takashi Miura, Souitirou Ebisawa, Tatsuya Saigusa, Koichiro Kuwahara. 2-Year Natural History of Lower Limbs in Patients With End-stage Renal Disease on Hemodialysis Due to Diabetic Nephropathy; From PREDICT Study. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017. 70. 18. B71-B71

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Education (3)：

1999 - 1999 京都大学大学院医学研究科臨床病態医科学
1995 - 1999 Kyoto University
1985 - 1991 Kyoto University

Work history (13)：

2023/08 - 現在信州大学医学部附属病院脳卒中・心臓病等総合支援センターセンター長
2023/04 - 現在信州大学医学部附属病院先端心臓血管病センターセンター長
2016/10 - 現在信州大学医学部附属病院胸痛センターセンター長
2016/10 - 現在信州大学医学部循環器内科学教室(内科学第五教室) 教授
2009/11 - 2016/09 Kyoto University

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Committee career (37)：

2023/10 - 現在日本腫瘍循環器学会理事
2023 - 現在日本循環器学会第89回・第90回日本循環器学会学術集会プログラム検討カテゴリー(心不全・心筋症・移植)メンバー
2022 - 現在日本高血圧学会学術委員
2022 - 現在日本高血圧学会評議員
2022 - 現在日本心臓病学会国際交流委員会委員

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Awards (15)：

2015/10 - 日本心不全学会学術賞
2015/04 - 日本臨床分子医学会学会賞
2013/03 - 日本心臓財団佐藤賞
2010/03 - 日本内分泌学会研究奨励賞
2009/10 - 日本心血管内分泌代謝学会第13回高峰譲吉研究奨励賞

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Association Membership(s) (20)：

日本循環器協会 , 日本腫瘍循環器学会 , 日本心血管インターベンション学会 , 日本心臓リハビリテーション学会( , 日本肺高血圧・肺循環器学会 , 日本抗加齢医学会 , 日本生理学会 , 国際心臓研究学会(ISHR)日本部会 , 日本高血圧学会 , 日本心エコー図学会 , 日本心臓病学会 , 日本不整脈心電学会 , 日本糖尿病学会 , 日本臨床分子医学会 , American Heart Association , 日本心不全学会 , 日本心血管内分泌代謝学会 , 日本内分泌学会 , 日本循環器学会 , 日本内科学会

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