Research theme for competitive and other funds (14):
2021 - 2023 分泌経路を含むマルチステップを標的とした核酸医薬による肝線維化治療
2020 - 2023 小胞体からの巨大分子分泌と外界シグナルによる分泌制御機構の解明
2020 - 2022 小胞体上の分泌ゾーンERESの局在決定機構
2019 - 2022 Identification of Factors Responsible for Liver Fibrosis Focusing on Secretory Pathways and Development of Novel Therapeutic Agents
2017 - 2020 Functional analysis of novel membrane complexes involved in collagen secretion and ERES formation
2014 - 2018 Mechanisms of large cargoes secretion
2014 - 2018 Analysis of activation mechanism and physiological function of ARL family small GTPases
2011 - 2016 Analysis of the regulation and mode of action of atypical G-protein cycles
2011 - 2015 Analysis of atypical small GTPases involved in membrane dynamics
2012 - 2014 Mechanism of large protein secretion regulated by small GTPase and complex localized at the ER
2011 - 2013 表皮水疱症及び肝線維化の病態理解に向けたコラーゲン分泌機構の解明
2010 - 2011 Mechanism of large protein secretion coordinated by the small GTPase and the ER-resident proteins
2009 - 2010 巨大分子の分泌を制御する新規小胞体膜蛋白質の機能解析
2005 - 2009 Functional analysis of atypical G proteins involved in cell signaling network
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Papers (33):
Miharu Maeda, Masashi Arakawa, Yukie Komatsu, Kota Saito. Small GTPase ActIvitY ANalyzing (SAIYAN) system: A method to detect GTPase activation in living cells. Journal of Cell Biology. 2024
Kota Saito, Miharu Maeda. p24 family Tango(1) at the endoplasmic reticulum exit site to organize cargo exit. Journal of Cell Biology. 2024
Miharu Maeda, Masashi Arakawa, Yukie Komatsu, Kota Saito. A Novel Method to Visualize Active Small GTPases Unveils Distinct Sites of Sar1 Activation During Collagen Secretion. 2024
Keiko Saegusa, Kohichi Matsunaga, Miharu Maeda, Kota Saito, Tetsuro Izumi, Ken Sato. Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells. Communications Biology. 2022. 5. 1
Miharu Maeda, Yukie Komatsu, Kota Saito. Mitotic ER exit site dynamics: insights into blockade of secretion from the ER during mitosis. Molecular & Cellular Oncology. 2020. 7. 6. 1832420-1832420