Hattori Akira

Affiliation and department：

Research field (1)： Cell biology

Research theme for competitive and other funds (32)：

2022 - 2026 脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略
2022 - 2025 ユビキチン修飾反応による細胞間接着維持の分子メカニズムの解明と創薬への応用
2021 - 2025 新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用
2019 - 2022 Design, Synthesis and Evaluation of Biologically Active Molecules Based on Ring Strain
2019 - 2021 Identification and analysis of a new group of diseases with a common etiology of abnormal immune response to embryonic signals

2017 - 2020 Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system

2017 - 2019 Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage

2016 - 2019 Identification of non-canonical degradation pathway of HIF-1 alpha promoted by de-ubiqutinating enzyme inhibitor.

2016 - 2019 Stereocontrolled synthesis of poly-substituted medium-sized cyclic compounds by electrocyclic ring opening reaction and the synthesis of biologically active molecules

2016 - 2017 Analysis of chorionic villi-derived embryo stem cells by novel sten cell markers, laeberin and hTERT

2015 - 2017 Role of ERAP1 in the pathogenesis of mental disorders

2014 - 2017 Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application

2013 - 2016 Pathophysiological roles of M1 aminopeptidases

2013 - 2016 Discovery of new reactions and utilities of 4-membered carbocyles based on their unique ring strains.

2012 - 2015 Role of aminopeptidases in atherosclerosis

2012 - 2014 Mechanism of unanchored polyubiquitin chain production

2011 - 2014 Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placentation

2011 - 2014 Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics

2011 - 2013 抗原トリミングアミノペプチダーゼの作用発現メカニズムと制御

2012 - 2012 Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin

2010 - 2010 免疫系による発生初期胚の認識機構-透明帯を利用した哺乳類の着床誘導戦略の証明-

2008 - 2010 Biological Function of the M1 Family of Human Aminopeptidases

2008 - 2010 Analysis of tissue remodeling mechanisms by circulating blood cells during human reproduction

2006 - 2008 Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases

2006 - 2007 小胞体におけるMHCクラスI提示抗原のN末端トリミング過程の分子メカニズム解析

2004 - 2005 抗原ペプチドプロセシングにおける小胞体アミノペプチダーゼの作用メカニズムの解明

2004 - 2005 血管新生の制御を目指した新たな標的分子の探索

2003 - 2005 The oxytocinase subfamily of M1 aminopeptidases

2002 - 2003 オキシトシナーゼサブファミリーの細胞内膜系局在の意義およびそのメカニズムの解明

2000 - 2001 オキシトシナーゼサブファミリーに属する新規酵素の生理機能の解明

1999 - 2001 STRUCTURE AND FUNCTION OF NOVEL AMINOPEPTIDASES BELONGING TO OXYTOCINASE SUB-FAMILY

1998 - 1999 腫瘍壊死因子によるアポトーシス誘導のシグナル系におけるcPLA_2の役割の解明

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Papers (96)：

Yanjun Pan, Takehiro Suzuki, Kazuko Sakai, Yoshinori Hirano, Hiroaki Ikeda, Akira Hattori, Naoshi Dohmae, Kazuto Nishio, Hideaki Kakeya. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. European journal of pharmacology. 2023. 960. 176156-176156
飯塚崇, 鈴木拓馬, 鏡京介, 松本多圭夫, 山崎玲奈, 八十島巌, 田中有華, 大黒多希子, 堀江昭史, 小野政徳, et al. 「胎盤の形成と形成細胞及び妊娠成立のための免疫機構の新知見」ヒト絨毛外栄養膜細胞による新規の免疫寛容誘導機構. 日本生殖医学会雑誌. 2023. 68. 4. 315-315
Takuma Suzuki, Takashi Iizuka, Kyosuke Kagami, Takeo Matsumoto, Rena Yamazaki, Takiko Daikoku, Akihito Horie, Masanori Ono, Akira Hattori, Hiroshi Fujiwara. Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human monocytes. iScience. 2023. 26. 9. 107692-107692
Takuro Matsuoka, Akira Hattori, Shinya Oishi, Mitsugu Araki, Biao Ma, Toshiki Fujii, Norihito Arichi, Yasushi Okuno, Hideaki Kakeya, Sho Yamasaki, et al. Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands. Journal of medicinal chemistry. 2023. 66. 17. 12520-12535
Tatsuhito Kanda, Kyosuke Kagami, Takashi Iizuka, Haruki Kasama, Takeo Matsumoto, Yuya Sakai, Takuma Suzuki, Megumi Yamamoto, Ayumi Matsuoka, Rena Yamazaki, et al. Spheroid formation induces chemokine production in trophoblast-derived Swan71 cells. American journal of reproductive immunology (New York, N.Y. : 1989). 2023. 90. 2. e13752

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MISC (75)：

神田龍人, 鏡京介, 飯塚崇, 笠間春輝, 松本多圭夫, 坂井友哉, 鈴木拓馬, 山本惠, 松岡歩, 山崎玲奈, et al. Swan71細胞株はスフェロイド培養でケモカインの発現が上昇する. 日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集. 2023. 41st-31st
平井杏奈, 鈴木優香, 中村孝博, 小川健司, 服部明, 辻本雅文, 後藤芳邦. Dysfuction of ER-aminopeptidase 1 induce serotonin-dependent anxiety. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
松岡巧朗, 本園千尋, 本園千尋, 服部明, 掛谷秀昭, 山崎晶, 山崎晶, 大石真也, 大野浩章, 井貫晋輔. MAIT細胞の活性化を担うMR1リガンドの構造活性相関研究. 創薬懇話会講演要旨集. 2022. 2022
松岡巧朗, 服部明, 大石真也, 有地法人, 掛谷秀昭, 山崎晶, 山崎晶, 大野浩章, 井貫晋輔. Identification of a novel MR1 ligand by screening with split-luciferase and its structure-activity relationship study. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)
山岡庸介, 立石海斗, 山川拓朗, 服部明, 瀧川紘, 掛谷秀昭, 高須清誠. Total Synthesis of Cryptopleurine Derivatives and their Bioactivity Evaluation. 日本薬学会年会要旨集(Web). 2021. 141st

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Patents (4)：

Lectures and oral presentations (19)：

TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する
(2018)
脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御.
(2016)
脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定
(第89回日本生化学会大会 2016)
脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析
(日本薬学会134年会 2014)
脱Urm1化活性の検出および分子同定
(日本薬学会134年会 2014)

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