Rchr
J-GLOBAL ID:201401073899761214
Update date: Nov. 13, 2024
Yoshikawa Takeo
ヨシカワ タケオ | Yoshikawa Takeo
Affiliation and department:
Job title:
Professor
Homepage URL (1):
https://pharmacology1.med.hokudai.ac.jp/
Research field (1):
Pharmacology
Research theme for competitive and other funds (13):
- 2023 - 2027 中枢神経系脆弱性と全身麻酔に関連した周術期認知機能障害の神経病理解析
- 2022 - 2025 Elucidation of important research issues to be solved in pharmacological research on histamine
- 2021 - 2024 Analysis of heparanse in skeletal muscles
- 2020 - 2023 吸入麻酔薬の意識消失作用におけるニューロテンシン神経系の役割
- 2019 - 2022 Translational research of a 18F-labeled cation type myocardium perfusion imaging agent
- 2018 - 2021 Mechanism of histamine-induced aggresive behaviors in mice
- 2016 - 2018 Development of a novel labeling method for affibody by F-18 labeled amino acid and a cell-free protein synthesis system
- 2016 - 2018 Importance of histamine metabolizing enzyme in the brain
- 2014 - 2018 Analysis of histamine system through genetically modified mice
- 2014 - 2016 Analysis of plasma membrane monoamine transporter in brain
- 2014 - 2015 Molecular mechanism of brain histamine clearance
- 2012 - 2014 Generation of molecular imaging pharmacology using small primate mamosets
- 2009 - 2011 Integrated research of histamine system from molecular to wholeanimals and humans using leading-edge technologies
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Papers (100):
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Fumito Naganuma, Birkan Girgin, Anne Bernadette S Agu, Kyosuke Hirano, Tadaho Nakamura, Kazuhiko Yanai, Ramalingam Vetrivelan, Takatoshi Mochizuki, Masashi Yanagisawa, Takeo Yoshikawa. Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy. SLEEP. 2024
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Fumito Naganuma, Mudasir Khanday, Sathyajit Sai Bandaru, Whidul Hasan, Kyosuke Hirano, Takeo Yoshikawa, Ramalingam Vetrivelan. Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus. Experimental Neurology. 2024
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Kensuke Sakaji, Sara Ebrahimiazar, Yasuhiro Harigae, Kenichi Ishibashi, Takeya Sato, Takeo Yoshikawa, Gen-ichi Atsumi, Ching-Hwa Sung, Masaki Saito. MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1. Life Science Alliance. 2023. 6. 11. e202301947-e202301947
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Nami Tateyama, Teizo Asano, Tomohiro Tanaka, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Guanjie Li, Ren Nanamiya, Takeo Yoshikawa, Mika K Kaneko, et al. Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies (C3Mab-6 and C3Mab-7). Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023. 42. 2. 68-72
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Yu Isoda, Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Kaishi Kitamura, Yuma Kudo, Ryo Ejima, Kazuki Ozawa, Takeo Yoshikawa, Mika K Kaneko, et al. Epitope Mapping of the Novel Anti-Human CCR9 Monoclonal Antibody (C9Mab-11) by 2 × Alanine Scanning. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023. 42. 2. 73-76
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MISC (101):
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吉川雄朗, GIRGIN Birkan, AGU Anne Bernadette, 谷内一彦, 中村正帆, 長沼史登. ヒスタミン代謝酵素阻害薬の薬理作用について. 日本ヒスタミン学会プログラム・講演要旨集. 2024. 24th
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吉川雄朗, 長沼史登, 長沼史登, 長谷茜音, 谷内一彦, 中村正帆, 中村正帆. ヒスタミン代謝酵素阻害剤メトプリンの行動薬理学的検討. 日本薬理学雑誌. 2023. 158. Supplement
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長沼史登, 長沼史登, GIRGIN Birkan, BERNADETTE S Agu Anne, 中村正帆, 谷内一彦, 吉川雄朗, 吉川雄朗. ヒスタミン代謝酵素阻害薬のナルコレプシー治療に対する有用性の検討. 時間生物学. 2023. 29. 2
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中村 正帆, 長沼 史登, 田中 聖人, 井上 まり絵, 直野 留美, 吉川 雄朗, 岡村 信行. 扁桃体中心核ニューロテンシン神経細胞の睡眠覚醒サイクルにおける役割の検討. 応用薬理. 2022. 102. 5-6. 128-128
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吉川 雄朗, 松澤 拓郎, 谷内 一彦, 山口 祐. ブドウ糖代謝におけるヘパラン硫酸の役割について. 糖尿病. 2022. 65. Suppl.1. S-282
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Books (1):
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創薬技術の革新 マイクロドーズからPET分子イメージングへの新展開
メディカルドゥ 2010
Lectures and oral presentations (298):
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ヒスタミン神経系を標的とした創薬研究について
(2024年度脳科学研究教育センター合宿研修 2024)
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視床下部外側ニューロテンシン神経の覚醒調節における重要性の検討
(第75回日本薬理学会北部会 2024)
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過眠症治療におけるヒスタミン代謝酵素阻害薬の有効性評価
(第75回日本薬理学会北部会 2024)
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Evaluation of histamine N-methyltransferase inhibition on sleep- wake behavior in wild-type and narcolepsy model mice
(第37回北海道薬物作用談話会 2024)
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Evaluation of Therapeutic Potential for Histamine N-methyltransferase Inhibitior in Narcolepsy
(Neuro2024 2024)
more...
Education (2):
- 2004 - 2008 Tohoku University Graduate School, Division of Medical Sciences
- 1996 - 2002 Tohoku University School of Medicine
Professional career (1):
Work history (5):
- 2023/10 - 現在 北海道大学脳科学研究教育センター 教員
- 2023/05 - 現在 Hokkaido University Graduate School of Medicine, Department of Neuropharmacology Professor
- 2016/04 - 2023/04 Tohoku University Graduate School of Medicine
- 2009/04 - 2016/03 Tohoku University Graduate School of Medicine
- 2002/04 - 2004/03 福島県太田総合病院附属太田西ノ内病院 研修医
Awards (7):
Association Membership(s) (7):
日本糖尿病学会
, 日本生化学会
, 日本神経科学学会
, 日本薬理学会
, Society for Neuroscience
, 日本臨床薬理学会
, 日本糖質学会
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