Horie Takahiro

Affiliation and department：

Research field (1)： Cardiology

Research theme for competitive and other funds (10)：

2023 - 2026 Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression
2020 - 2023 Elucidation of the functions of long non-coding RNA in cardiovascular diseases
2020 - 2023 コレステロールにより制御される長鎖非コードRNAの機能解析とその臨床応用
2017 - 2020 Elucidation of global metabolic control mechanisms by microRNA-33a/b and development of specific regulatory strategy using artificial nucleic acid
2017 - 2020 Investigation of the role of microRNAs in the formation of liver fibrosis

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Papers (94)：

Tsugunori Maruyama, Sho Matsui, Ryosuke Kobayashi, Takuro Horii, Yasuo Oguri, Satoshi Tsuzuki, Takahiro Horie, Koh Ono, Izuho Hatada, Tsutomu Sasaki. Medium-Chain Triglycerides-Specific Appetite is Regulated by the β-oxidation of Medium-Chain Fatty Acids in the Liver. American journal of physiology. Endocrinology and metabolism. 2024
Yugo Yamashita, Daiki Hira, Makiko Morita, Yurie Katsube, Masahito Takakura, Hiroko Tomotaki, Seiichi Tomotaki, Wei Xiong, Hiroki Shiomi, Takahiro Horie, et al. Potential treatment option of rivaroxaban for breastfeeding women: A case series. Thrombosis research. 2024. 237. 141-144
Sijia Xu, Hiroki Shiomi, Yugo Yamashita, Satoshi Koyama, Takahiro Horie, Osamu Baba, Masahiro Kimura, Yasuhiro Nakashima, Naoya Sowa, Koji Hasegawa, et al. CRISPR-Cas9-guided amplification-free genomic diagnosis for familial hypercholesterolemia using nanopore sequencing. PloS one. 2024. 19. 3. e0297231
Sawa Miyagawa, Takahiro Horie, Tomohiro Nishino, Satoshi Koyama, Toshimitsu Watanabe, Osamu Baba, Tomohiro Yamasaki, Naoya Sowa, Chiharu Otani, Kazuki Matsushita, et al. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis. Life science alliance. 2023. 6. 8
Tomohiro Yamasaki, Takahiro Horie, Satoshi Koyama, Tetsushi Nakao, Osamu Baba, Masahiro Kimura, Naoya Sowa, Kazuhisa Sakamoto, Kazuhiro Yamazaki, Satoshi Obika, et al. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways. Scientific Reports. 2022. 12. 1

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MISC (82)：

小松(藤井)貴義, 渡部宏俊, 豊田俊彬, 塩見紘樹, 田崎淳一, 堀江貴裕, 加藤貴雄, 齋藤成達, 木村剛. たこつぼ型心筋症に無症候性冠動脈3枝病変を合併した一例. 日本循環器学会近畿地方会(Web). 2018. 125th
Masataka Nishiga, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Tetsushi Nakao, Tomohiro Nishino, Daihiko Hakuno, Yasuhiro Nakashima, Kazuya Nagao, Koji Hasegawa, et al. MicroRNA-33 Maintains Cellular Cholesterol Content in Fibroblasts and Fibrotic Response in Heart. CIRCULATION. 2016. 134
Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Masataka Nishiga, Tetsushi Nakao, Tomohiro Nishino, Fumiko Nakazeki, Satoshi Koyama, Takeshi Kimura, Koh Ono. Overexpression of the lincRNA Regulated by Pressure-Overload Leads to Cardiomyocyte Hypertrophy. JOURNAL OF CARDIAC FAILURE. 2016. 22. 9. S206-S206
Satoshi Koyama, Takashi Kuragaichi, Yukihito Sato, Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Takeshi Kimura, Koh Ono. Changes and Physiological Meanings of Serum microRNA during Therapeutic Course of Acute Heart Failure. JOURNAL OF CARDIAC FAILURE. 2016. 22. 9. S178-S179
Kazuya Nagao, Hiroshi Yukawa, Kiyotaka Shimamura, Masataka Nishiga, Takahiro Horie, Koh Ono, Yukihito Sato, Tsukasa Inada, Toshinori Makita, Masaru Tanaka. Relationship between Systemic Remodeling of Extracellular Matrix (ECM) and Clinical Course of the Diseases in Heart Failure. JOURNAL OF CARDIAC FAILURE. 2016. 22. 9. S164-S164

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Awards (6)：

2015/12 - 第23回日本血管生物医学会学術集会 YIA優秀賞
2014/12 - 第29回岡本研究奨励賞
2014/04 - 第51回日本臨床分子医学会学術集会学術奨励賞
2013/07 - 第45回日本動脈硬化学会総会若手研究者奨励賞最優秀賞
2012/12 - 第1回万有医学奨励賞優秀賞

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