Nozawa Takashi

Affiliation and department：

Research field (1)： Bacteriology

Research theme for competitive and other funds (17)：

2024 - 2027 多様な細菌感染に対するロバストネスを支えるゼノファジー機構の解明
2023 - 2026 Elucidation of the mechanism of competition between different bacterial species via extracellular vesicles and its application to the development of new drug discovery technologies
2022 - 2025 A群レンサ球菌の金属輸送系を標的とした治療薬剤としての人工抗体の取得
2022 - 2025 Elucidation of Xenophagy Regulation by Bacterial Glycan Recognition
2021 - 2024 A群レンサ球菌の分泌毒素Ngaの新規機能による宿主制御機構の解析

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Papers (48)：

Yu Kawagishi, Teresia M Kimeu, Kazunori Murase, Akemi Yoshida, Atsuko Minowa-Nozawa, Takashi Nozawa, Yasuhiro Tsuchido, Taro Noguchi, Miki Nagao, Saeko Nakajima, et al. Complete genome sequence of three Staphylococcus epidermidis strains isolated from patients with skin diseases in Japan. Microbiology resource announcements. 2024. e0017924
Junpei Iibushi, Takashi Nozawa, Hirotaka Toh, Ichiro Nakagawa. ATG9B regulates bacterial internalization via actin rearrangement. iScience. 2024. 27. 5. 109623-109623
Takashi Nozawa, Hirotaka Toh, Junpei Iibushi, Kohei Kogai, Atsuko Minowa-Nozawa, Junko Satoh, Shinji Ito, Kazunori Murase, Ichiro Nakagawa. Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy. Nature Communications. 2023. 14. 1
Chihiro Aikawa, Akihide Shimizu, Makoto Nakakido, Kazunori Murase, Takashi Nozawa, Kouhei Tsumoto, Ichiro Nakagawa. Group A Streptococcus cation diffusion facilitator proteins contribute to immune evasion by regulating intracellular metal concentrations. Biochemical and biophysical research communications. 2023. 676. 141-148
Miyako Hikichi, Hirotaka Toh, Atsuko Minowa-Nozawa, Takashi Nozawa, Ichiro Nakagawa. Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation. Cellular Microbiology. 2022. 2022

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MISC (7)：

Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa. TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy. Nature communications. 2020. 11. 1. 770-770
Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa. Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells. Frontiers in cellular and infection microbiology. 2019. 9. 398-398
大倉正稔, 野澤孝志, 渡辺孝康, 中川一路, 高松大輔, 大崎慎人, 関崎勉, 浜田茂幸, 丸山史人. ゲノム解析から明らかとなったStreptococcus suisにおける曖昧な種の境界及び進化の鍵となるスポット. 日本細菌学雑誌. 2015. 70. 1
山田俊介, 柴崎真樹, 渡辺孝康, 相川知宏, 野澤孝志, 丸山史人, 中川一路. CRISPR-プロファージ相互作用解析から見出されたA群レンサ球菌のゲノム進化機構. 日本細菌学雑誌. 2015. 70. 1
渡辺孝康, 野澤孝志, 丸山史人, 中川一路. P25-42 CRISPRを保有するバクテリオファージの系統学的普遍性(ポスター発表). 日本微生物生態学会講演要旨集. 2014. 2014. 259-259

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Lectures and oral presentations (4)：

TBC1D9を介したカルシウムシグナリングはTBK1依存性ゼノファジーを制御する
(第92回日本細菌学会総会 2019)
選択的オートファジーを制御するRab GTPaseネットワーク
(第26回母子医療センターシンポジウム 2019)
細胞内病原体センサーNLRP4はRho-アクチン制御を介してA群レンサ球菌に対するオートファジーを誘導する
(第91回日本生化学会大会 2018)
The Rab35 GTPase and TBK1 mark targets of autophagosomes by recruiting NDP52
(The 17th Awaji International Forum on Infection and Immunity 2018)

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