J-GLOBAL ID:201401089160331894   Update date: Mar. 31, 2021

Kozaka Takashi

コザカ タカシ | Kozaka Takashi
Affiliation and department:
Job title: Assistant Professor
Homepage URL  (1): http://ri-center.w3.kanazawa-u.ac.jp/
Research field  (1): Radiology
Research keywords  (1): Organic synthetic chemistry, Radiopharmaceutical chemistry, Molecular imaging
Research theme for competitive and other funds  (4):
  • 2014 - 2017 アルツハイマー病の早期診断用シナプス前コリン作動性神経分子イメージング剤の開発
  • 2014 - 2016 固形腫瘍の早期発見・増殖能診断を目的としたσ-2受容体イメージング剤の開発研究
  • 2011 - 2013 アルツハイマー病の早期診断を目的としたコリントランスポーターイメージング剤の開発
  • 2011 - 2013 脳内σ-1受容体イメージングによる老化及びストレス性疾患の客観的評価に関する研究
Papers (32):
  • Taiki Shigeno, Takashi Kozaka, Yoji Kitamura, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT. Annals of nuclear medicine. 2021. 35. 2. 167-175
  • Daisuke Miwa, Yoji Kitamura, Takashi Kozaka, Taiki Shigeno, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba. (-)-o-[11 C]methyl-trans-decalinvesamicol ((-)-[11 C]OMDV) as a PET ligand for the vesicular acetylcholine transporter. Synapse (New York, N.Y.). 2020. 74. 11. e22176
  • Tuyen Thuy Bich Ho, Alessandro Nasti, Akihiro Seki, Takuya Komura, Hiiro Inui, Takashi Kozaka, Yoji Kitamura, Kazuhiro Shiba, Taro Yamashita, Tatsuya Yamashita, et al. Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis. Journal for immunotherapy of cancer. 2020. 8. 2
  • Kazuma Ogawa, Ryohei Masuda, Kenji Mishiro, Mengfei Wang, Takashi Kozaka, Kazuhiro Shiba, Seigo Kinuya, Akira Odani. Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging. Bioorganic & medicinal chemistry. 2019. 27. 10. 1990-1996
  • Ogawa Kazuma, Masuda Ryohei, Mishiro Kenji, Wang Mengfei, Kozaka Takashi, Shiba Kazuhiro, Kinuya Seigo, Odani Akira. Syntheses and evaluation of azavesamicol homologous as radioiodine labeled probes for sigma-1 receptor imaging. JOURNAL OF NUCLEAR MEDICINE. 2019. 60
MISC (1):
  • K. Ogawa, H. Kanbara, K. Shiba, Y. Kiyono, T. Mori, Y. Kitamura, T. Kozaka, T. Kiwada, A. Odani. Development and evaluation of a radiobromine labeled sigma ligand for tumor imaging. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2011. 38. S147-S147
Lectures and oral presentations  (58):
  • Study on the Application of ATR for the Measurement of Infrared Absorption Spectrum of Food Adductives Identification Tests
    (137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
  • The structure-activity relationship between structure of vesamicol analogs and affinity of VAChT and sigma receptors.
    (137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
  • The possibility of vesamicol analog with 5-membered ring as a sigma-1 receptor imaging probe
    (137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
  • Changes of the dopamine nerve system by stress in the model mouse for 15q duplication.
    (137th Annual Meeting of the Pharmaceutical Society of Japan 2017)
  • SPECT用σ-2受容体イメージング剤[<sup>123</sup>I]PIDVの開発研究
    (第56回日本核医学会学術総会 2016)
Professional career (1):
  • 博士(薬学)
Association Membership(s) (6):
Society of Nuclear Medicine and Molecular Imaging ,  Japanese Society of Radiation Safety Management ,  Japan Radioisotope Association ,  Japanese Society for Molecular Imaging ,  The Pharmaceutical Society of Japan ,  The Japanese Society of Nuclear Medicine
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