2020 - 2023 Optogenetic regulation of function, regeneration and diseases of the female reproductive organ using stem cell and genome editing technologies
2019 - 2022 Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9
2021 - 2022 iPS細胞由来ヒト軟骨前駆細胞ペースト(Chondro-paste)の開発
2017 - 2019 Regeneration and functional control of the uterus using decellularization technologies in non-human primates
2016 - 2019 Regulation of uterine endometrial function using photogenetics and tissue engineering: its possible therapeutic potential
2016 - 2019 Development and Molecular regulatory mechanism of mesenchymal epithelial transition (MET) model
2015 - 2017 Development of uterine leiomyoma model using CRISPR/CAS9 genome editing system
2011 - 2016 子宮内膜細胞の老化逸脱へのゲノム多様性の関与
2013 - 2016 The mechanism of signal for regulating differentiation in human trophoblast stem cells
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Papers (34):
Shojiro Hanaki, Daisuke Yamada, Tomoka Takao, Ryosuke Iwai, Takeshi Takarada. Efficient Production of Chondrocyte Particles from Human iPSC-Derived Chondroprogenitors Using a Plate-Based Cell Self-Aggregation Technique. International journal of molecular sciences. 2024. 25. 22
Taro Osawa, Daisuke Yamada, Tomoka Takao, Lu Ming, Takeshi Takarada. PRRX1 upregulates PD-L1 in human mesenchymal stem cells. In Vitro Cell Dev Biol Anim. 2024
Shota Takihira, Daisuke Yamada, Tatsunori Osone, Tomoka Takao, Masakiyo Sakaguchi, Michiyuki Hakozaki, Takuto Itano, Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, et al. PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours. British journal of cancer. 2024. 130. 9. 1493-1504
Yuki Fujisawa, Tomoka Takao, Daisuke Yamada, Takeshi Takarada. Development of cartilage tissue using a stirred bioreactor and human iPSC-derived limb bud mesenchymal cells. Biochemical and biophysical research communications. 2023. 687. 149146-149146
Tomoyuki Ota, Tomoka Takao, Ryosuke Iwai, Takeshi Moriwaki, Yohei Kitaguchi, Yuki Fujisawa, Daisuke Yamada, Yoshihiro Kimata, Takeshi Takarada. Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique. Biomedical materials (Bristol, England). 2023. 18. 6
花木祥二朗, 花木祥二朗, 高尾知佳, 藤澤佑樹, 山田大祐, 岩井良輔, 宝田剛志. Development of Regenerative Therapy for Pediatric Tracheal Disorders using Human iPSC-Derived Cartilage Tissue. 日本小児外科学会雑誌. 2024. 60. 3. 509-509
2023/10 - award Limb development lineage of human induced pluripotent stem cell-derived limb bud mesenchymal cells
2023/09 - 第95回日本組織培養学会 English Presentation Award (EPA) Production of hyaline cartilage sheet using human induced pluripotent stem cell- derived chondrocyte precursor cells
2021/11 - Excellence Award for the 3rd SMF Paper Award Project Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9
2021/11 - Japan Society for Reproductive Medicine Academic Encouragement Award Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR/Cas9
2012/09 - International Federation of Placenta Associations (IFPA) Y.W. Loke New Investigator Travel Awards Isolation and characterization of human trophoblast progenitor cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line