Uchibori ryosuke

ウチボリリヨウスケ | Uchibori ryosuke

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/20458285.ja.html

Research field (2)： Tumor diagnostics and therapeutics , Hematology and oncology

Research keywords (7)：キメラ抗原受容体 , 多発性骨髄腫 , B細胞性腫瘍 , 細胞治療 , 遺伝子治療 , 癌 , 間葉系幹細胞

Research theme for competitive and other funds (5)：

2019 - 2022 Development of selective regulatory system for proliferation and persistence of CAR-T cells
2016 - 2018 Development of CD269-CAR T cells for the adoptive immunotherapy of multiple myeloma.
2012 - 2015 Development of gene therapy for refractory non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor
2012 - 2014 Development of switch promoters driven by activation signals from the chimeric antigen receptors.
2009 - 2011 Development of gene therapy using bone-marrow-derived mesenchymal stem cells

Papers (46)：

Yoshihide Sehara, Yuki Hashimotodani, Ryota Watano, Kenji Ohba, Ryosuke Uchibori, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami. Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus. Molecular neurobiology. 2024
Somsak Prasongtanakij, Sarinthip Preedagasamzin, Bunyada Jittorntrum, Usanarat Anurathapan, Teeraya Puavilai, Pimjai Niparuck, Pichika Chantrathammachart, Thanakrit Piyajaroenkij, Kitipong Uaesoontrachoon, Ryosuke Uchibori, et al. Cytotoxicity and exhaustion markers of chimeric antigen receptor T cells targeting BCMA in multiple myeloma cell lines between patients and healthy donors. European Journal of Haematology. 2023
内堀亮介, 大嶺謙. 【遺伝子治療update】CAR-T細胞療法の現状と課題. BIO Clinica. 2022. 37. 6. 525-529
Ken Ohmine, Ryosuke Uchibori. Novel immunotherapies in multiple myeloma. International Journal of Hematology. 2022. 115. 6. 799-810
内堀亮介, 大嶺謙. AMLに対するCAR-T療法の開発の現状と新規CD70特異的CAR-T. 血液内科. 2022. 84. 5. 730-736

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MISC (30)：

T. Yoshiba, Y. Saga, Y. Sehara, R. Uchibori, M. Urabe, H. Fujiwara, S. Matsubara, H. Mizukami. Efficient targeting of uterine cervical cancer using AAV vectors encoding CRISPR/Cas9 against HPV-E6 gene. HUMAN GENE THERAPY. 2017. 28. 12. A24-A25
Ryosuke Uchibori, Ken Ohmine, Yoshihide Sehara, Masashi Urabe, Hiroaki Mizukami, Junichi Mineno, Kazuto Takesako, Keiya Ozawa. Effect of CAR-T Therapy on Bone Lesions in Myeloma Mouse Model. MOLECULAR THERAPY. 2017. 25. 5. 58-58
Hiroaki Mizukami, Tsukasa Ohmori, Ryosuke Uchibori, Yasushi Saga, Masashi Urabe, Akihiro Kume, Yoichi Sakata, Keiya Ozawa. Duration of Factor IX Expression in Macaques Following AAV8-Mediated Liver Transduction. MOLECULAR THERAPY. 2016. 24. S87-S87
Masashi Urabe, Ryosuke Uchibori, Akihiro Kume, Hiroaki Mizukami, Keiya Ozawa. The Use of Thymidine Kinase Mutants as a Safeguard Switch for IPS Cells. MOLECULAR THERAPY. 2016. 24. S95-S96
Ryosuke Uchibori, Takeshi Teruya, Ken Ohmine, Masashi Urabe, Yasushi Saga, Hiroaki Mizukami, Junichi Mineno, Kazuto Takesako, Keiya Ozawa. CD269 (BCMA)-Specific CAR-Expressing T Cells Dramatically Eradicate Myeloma Cells from Bone Marrow of an Orthotopic Multiple Myeloma Mouse Model. MOLECULAR THERAPY. 2016. 24. S158-S159

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Books (1)：

The biology and therapeutic application of mesenchymal cells
Wiley Blackwell 2017 ISBN:1118907515

Professional career (1)：

Work history (3)：

Awards (4)：

2013 - American Society of Gene & Cell Therapy Outstanding Poster Presentation Award
2012/11 - 自治医科大学自治医科大学医学部最優秀論文賞
2011/04 - 自治医科大学自治医科大学医学部研究奨励賞
自治医科大学自治医科大学大学院医学研究科研究奨励賞

Association Membership(s) (4)：

AMERICAN SOCIETY OF GENE & CELL THERAPY , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE CANCER ASSOCIATION , JAPAN SOCIETY OF GENE THERAPY

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