Research theme for competitive and other funds (6):
2022 - 2025 Prediction of drug disposition into brain in elders using clusters of daily variation in gene expression
2021 - 2025 Elucidation of the mechanism of V1a receptor-induced uterine contraction via receptor coordination and derivation of therapeutic targets for preterm birth
2017 - 2020 Can we prevent analgesic tolerance to morphine? Study of high-order opioid receptor signal complex and its clinical application.
2012 - 2015 Adverse effects of vasopressin receptor deficiency on the male reproductive defect
2009 - 2011 The study of the PGE_2 as a new sexual differentiation factor in the brain.
2009 - 2011 Drug development using accelerated aging model
Nuttawadee Ngamlertwong, Hiroyoshi Tsuchiya, Yuta Mochimaru, Morio Azuma, Takahiro Kuchimaru, Taka-Aki Koshimizu. Agonist dependency of the second phase access of β-arrestin 2 to the heteromeric μ-V1b receptor. Scientific reports. 2021. 11. 1. 15813-15813
Hiroyoshi Tsuchiya, Shyota Fujimura, Yoko Fujiwara, Taka-Aki Koshimizu. Critical role of V1a vasopressin receptor in murine parturition†. Biology of reproduction. 2020. 102. 4. 923-934