Rchr
J-GLOBAL ID：201401094182251677   Update date: Feb. 22, 2024

Okada Hitoshi

オカダヒトシ | Okada Hitoshi
Affiliation and department：
近畿大学 医学部 生化学

About 近畿大学 医学部 生化学


Job title： 教授
Homepage URL  (2)： http://biochem-kindaimed.com/ ,  http://biochem-kindaimed.com/en/
Research field  (4)： Laboratory animal science ,  Medical biochemistry ,  Tumor biology ,  Pathobiochemistry
Research keywords  (6)： Aging ,  Metabolism ,  DNA damage response ,  Apoptosis ,  Epigenome ,  Tumor biology
Research theme for competitive and other funds  (16)：
  • 2021 - 2024 代謝ストレスにより誘導される新規肝がんモデルの作製と機能解析
  • 2019 - 2022 TGFbによるSirt1の制御と炎症性腸疾患の抑制機構の解明
  • 2019 - 2022 ヒト-細菌叢間 化学コミュニケーションの理解と炎症性腸疾患・がん・がん免疫
  • 2018 - 2021 代謝制御とがん組織微小環境を結ぶネットワーク機構の解明
  • 2018 - 2019 Elucidation of epigenetics-mediated glucose and lipid metabolism
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Papers (64)：
  • Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Masahiko Honda, Ryoichi Sugisawa, Hitoshi Okada. Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer. Cell death & disease. 2024. 15. 2. 131-131
  • Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada. MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance. Molecular cancer research : MCR. 2023. 21. 5. 444-457
  • Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada. KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility. FASEB bioAdvances. 2021. 3. 12. 1020-1033
  • Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, et al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2021. 8. 18. e2004303
  • Sun-Ju Yi, You-Jee Jang, Hye-Jung Kim, Kyubin Lee, Hyerim Lee, Yeojin Kim, Junil Kim, Seon Young Hwang, Jin Sook Song, Hitoshi Okada, et al. The KDM4B-CCAR1-MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis. Bone research. 2021. 9. 1. 27-27
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MISC (90)：
  • 上田 健, Dash Suman, 本多 賢彦, 古室 暁義, 岡田 斉. 骨髄系腫瘍におけるNEDD化酵素の腫瘍抑制的な役割. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-479]
  • 岡田 斉, Dash Suman, 本多 賢彦, 古室 暁義, 上田 健. 網羅的CRISPRライブラリースクリーニングによるIFNγ-PD-L1経路制御因子の同定. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-493]
  • DASH Suman, 上田健, 古室暁義, 岡田斉. Gemcitabine-resistant PDAC cells with DCK deficiency show upregulated expression of MYC and glutamine target genes. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 古室暁義, 上田健, DASH Suman, 岡田斉. UTX-deficient promotes breast cancer invasion and lung metastasis. 日本癌学会学術総会抄録集(Web). 2023. 82nd
  • 本多賢彦, DASH Suman, 古室暁義, 上田健, 岡田斉. Functional analysis of Vgll2 in the regulation of skeletal muscle oxidative capacity. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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Books (1)：
  • ジーンターゲティングの実際
    実験医学 1996
Lectures and oral presentations  (15)：
  • エピジェネティクスから考える環境因子と肥満
    (第18回 日本抗加齢医学会総会プログラム 2018)
  • Role of histone demethylases in breast cancer development
    (The 76th Annual Meeting of the Japanese Cancer Association 2017)
  • マウスモデルを用いたDNA損傷応答制御による 治療関連白血病発症抑制の試み
    (第21回日本がん分子標的治療学会学術集会 2017)
  • Attenuated DNA damage repair delays therapy-related malignancies in mouse model
    (The 12th International Conference on Protein Phosphatase International Symposium 2016)
  • Attenuated DNA damage repair delays therapy-related malignancies in mouse model
    (The 75th Annual Meeting of the Japanese Cancer Association 2016)
ｍore...
Education (2)：
  • 1991 - 1995 Tohoku University
  • 1981 - 1987 Tohoku University School of Medicine
Professional career (1)：
  • MD, PhD (Tohoku Univ)
Work history (8)：
  • 2014/04 - 現在 Kindai University, Faculty of Medicine Dept. of Biochemistry Professor
  • 2012/07 - 2014/03 University of Toronto Dept. of Medical Biophysics Associate Professor
  • 2005/05 - 2014/03 Campbell Family Institute for Breast Cancer Research Staff Scientist
  • 2005/05 - 2014/03 Ontario Cancer Institute Scientist
  • 2005/11 - 2012/06 University of Toronto Dept. of Medical Biophysics Assistant Professor
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Association Membership(s) (5)：
THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  American Association for Cancer Research ,  THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY
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