Rchr
J-GLOBAL ID:201401094612410529
Update date: Sep. 07, 2024
Sadaie Mahito
サダイエ マヒト | Sadaie Mahito
Affiliation and department:
Job title:
Professor
Homepage URL (1):
http://www.rs.tus.ac.jp/msadaie/top.html
Research field (4):
Molecular biology
, Tumor biology
, Genomics
, Pharmaceuticals - health and biochemistry
Research keywords (8):
Cancer
, Senescence
, Cell Cycle
, Drug Discovery
, Telomere
, Chromatin
, Epigenetics
, Chromosome
Research theme for competitive and other funds (8):
- 2020 - 2023 天然化合物AusDに高い感受性を示すがん細胞の分子遺伝学的特徴の解明
- 2019 - 2022 天然化合物AusDの生物活性に高い感受性を示すがん細胞の分子遺伝学的特徴の解明
- 2018 - 2019 ATRXが関与するゲノム維持機能の分子ネットワークの解明と疾患理解への応用
- 2014 - 2018 Suppression of telomerase-independent telomere maintenance mechanism in cancer cells
- 2010 - 2011 細胞老化と癌抑制を誘導する遺伝子発現機構
- 2005 - 2008 SETドメインタンパク質によるタンパク質メチル化の生理機能
- 2008 - 2008 タンパク質メチル化酵素の機能とその修飾の役割の解明
- 2006 - 2007 タンパク質メチル化酵素の機能とその修飾の役割の解明
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Papers (20):
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Yukiko Kojima, Saki Fujieda, Liya Zhou, Masahiro Takikawa, Kouji Kuramochi, Toshiki Furuya, Ayaka Mizumoto, Noritaka Kagaya, Teppei Kawahara, Kazuo Shin-ya, et al. Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity. Cancer Science. 2024. 115. 9. 3054-3066
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Ayaka Mizumoto, Yuta Yokoyama, Tomoichiro Miyoshi, Masahiro Takikawa, Fuyuki Ishikawa, Mahito Sadaie. DHX36 maintains genomic integrity by unwinding G-quadruplexes. 2023. 28. 10. 694-708
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Yuichi Kato, Tomoka Inoue, Yuuki Furuyama, Kenji Ohgane, Mahito Sadaie, Kouji Kuramochi. Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile. TETRAHEDRON LETTERS. 2021. 86. 153519
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Claire J. Cairney, Lauren S. Godwin, Alan E. Bilsland, Sharon Burns, Katrina H. Stevenson, Lynn McGarry, John Revie, Jon D. Moore, Ceri M. Wiggins, Rebecca S. Collinson, et al. A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLOS GENETICS. 2017. 13. 8. e1006942
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Taku Furubayashi, Kazuya Motohashi, Keisuke Wakao, Tsuyoshi Matsuda, Isao Kii, Takamitsu Hosoya, Nobuhiro Hayashi, Mahito Sadaie, Fuyuki Ishikawa, Michio Matsushita, et al. Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2017. 139. 26. 8990-8994
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MISC (34):
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Matsuo, Y, Isobe, N, Takikawa, M, Hayashi, M, Ishikawa, F, Sadaie, M. Molecular basis of cellular senescence triggered by CDK inhibition. 2024
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滝川 雅大, 岡部 篤史, 金田 篤志, 石川 冬木, 定家 真人, 大木 理恵子. A novel extrinsic apoptosis pathway regulated via the p53-p53PAD7-Hippo-YAP/TAZ axis. The 10th International MDM2 Workshop. 2023
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滝川 雅大, 岡部 篤史, 金田 篤志, 石川 冬木, 定家 真人, 大木 理恵子. A novel extrinsic apoptosis pathway regulated via the p53-p53PAD7-Hippo-YAP/TAZ axis. 第82回日本癌学会学術総会. 2023
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定家 真人. がん細胞の無限増殖を保障するテロメア維持機構の解明と征圧. 科学フォーラム. 2023. 433. 2月号. 8-11
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小島有紀子, 滝川雅大, 新家一男, 旦慎吾, 石川冬木, 定家真人. 骨肉腫細胞に対する天然化合物AusDの細胞傷害性の分子メカニズム. 第81回日本癌学会学術総会. 2022
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Books (7):
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最新がん薬物療法学:合成致死を利用したがん治療
日本臨牀, 日本臨牀社 2014
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エピジェネティクスキーワード事典:老化
実験医学, 羊土社 2013
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老化・寿命のサイエンス:細胞老化における核とクロマチンの動態
実験医学, 羊土社 2013
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染色体サイクル:細胞老化におけるクロマチン構造変換のダイナミズム
蛋白質核酸酵素, 共立出版 2009
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細胞核-遺伝情報制御と疾患:細胞老化・個体老化における核構造と遺伝子発現の調節
実験医学, 羊土社 2009
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Lectures and oral presentations (21):
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がん細胞が無限に増えるしくみ
(東京理科大学オープンカレッジ 2023)
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がん細胞が無限に増えるしくみ
(東京理科大学オープンカレッジ 2022)
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がん細胞が無限に増えるしくみ
(東京理科大学オープンカレッジ 2021)
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がん細胞に抗がん剤さがしを手伝ってもらう
(第7回坊っちゃん講座 2021)
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The balance between fragility and stability of the genome in telomerase-independent cancer cells
(第43回分子生物学会年会 2020)
more...
Education (2):
- - 2004 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Department of Biological Information
- - 1997 Tohoku University Faculty of Agriculture Department of Applied Biosciences
Professional career (1):
- Ph.D. (Tokyo Institute of Technology)
Work history (8):
- 2024/04 - 現在 Tokyo University of Science Faculty of Science and Technology, Applied Biological Science Professor
- 2017/10 - 2024/03 Tokyo University of Science, Faculty of Science and Technology; Associate Professor
- 2013/11 - 2017/09 Kyoto University, Graduate School of Biostudies; Assistant Professor
- 2012/08 - 2013/10 Kyoto University, Graduate School of Biostudies; Research Fellow
- 2008/06 - 2012/07 Cancer Research UK, Cambridge Research Institute
- 2010/06 - 2011/05 Uehara Memorial Foundation Postdoctoral Research Fellow, Research Fellow
- 2002/04 - 2008/05 PRESTO JST Research Fellow, Research Fellow, Special Postdoctoral Researcher
- 2002/04 - 2008/05 Center for Developmental Biology, RIKEN
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Association Membership(s) (4):
International Cell Senescence Association
, 日本基礎老化学会
, 日本癌学会
, 日本分子生物学会
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