Akiyama Yoshinori

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (34)：

2022 - 2026 大腸菌BepAによる外膜タンパク質トリアージ機構とその制御
2018 - 2021 Physiological functions and selective substrate-cleavage mechanism of E. coli intramembrane protease RseP
2015 - 2018 Molecular mechanism for quality control of bacterial outer membrane by the periplasmic protease BepA
2015 - 2018 Mechanism of selective substrate cleqvage and novel cellular functions ofintramembrane protease RseP
2014 - 2018 Elucidation of substrate recognition mechanism of I-CLiP in the trans- and juxta-membrane regions

2015 - 2017 ビブリオ菌における新生鎖機能を介したタンパク質膜透過の制御

2012 - 2015 Analysis of a chaperone/protease involved in quality control of bacterial cell surface

2012 - 2015 A novel regulation mechanism of cellular functions by intramembrane proteolysis

2011 - 2012 Degradation mechanisms of sigma 32 by membrane targeting via SRP pathway

2010 - 2012 SecDF function and roles of the proton motive force in protein translocation

2008 - 2012 Nascent chain biology

2007 - 2011 Quality control of E. coli membrane proteins

2009 - 2010 膜内切断(RIP)プロテアーゼの細胞機能

2009 - 2010 X-ray Crystallographic analysis of membrane-bound AAA+ protease FtsH

2008 - 2010 Analysis of the membrane stress response in E. coli

2007 - 2008 大腸菌膜内切断(RIP)プロテアーゼの細胞機能と制御

2005 - 2007 Molecular mechanism ofreguLaled inframembrane proteolysis (RIP)

2002 - 2006 Cellular systems that control protein dynamism across the membrane

2003 - 2004 Control of extracytoplasmic stress responses by regulated intramembrane proteolysis

2000 - 2001 Regulation mechanism of the DsbA/DsbB system that catalyzes disulfine bond formation

1999 - 2001 Membrane protein degradation by E. coli FtsH

1997 - 1999 SecY functions that support the dynamic movement of SecA, a protein-translocating ATPase

1998 - 1998 膜結合型プロテアーゼ複合体とその多様な機能:大腸菌FtsH複合体の解析

1997 - 1998 Factors involved in the stop transfer process in membrane protein biogenesis

1997 - 1997 膜結合型プロテアーゼ複合体とその多様な機能:大腸菌Frsh複合体の解析

1997 - 1997 蛋白質の機造構築におけるジスルフィド結合の役割とその形成機構

1996 - 1996 膜結合プロテアーゼ複合体とその多様な機能:大腸菌FtsH複合体の解析

1995 - 1996 Quality control of an integral membrane protein, SecY.

1995 - 1996 Cellular factors that assist in membrane protein anchoring

1993 - 1994 大腸菌の新しいATPase相同体(FtsH)の膜タンパク質アンカリングにおける役割

1992 - 1992 ペリプラズムにおけるタンパク質folding因子PpfAの構造と機能

1990 - 1992 Dissection of polypeptide translocator function of SecY

1990 - 1990 無細胞系による膜タンパク質の膜組み込み機構とSecYの役割の解析

1987 - 1988 大腸菌のタンパク質膜透過に関与する膜タンパク質SecYの構造と機能の解析

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Papers (133)：

Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi, et al. The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. Journal of Biological Chemistry. 2024. 107476-107476
Tatsuhiko Yokoyama, Yutaro Yamagata, Saisei Honna, Shinya Mizuno, Shizuka Katagiri, Rika Oi, Terukazu Nogi, Yohei Hizukuri, Yoshinori Akiyama. S2P intramembrane protease RseP degrades small membrane proteins and suppresses the cytotoxicity of intrinsic toxin HokB. mBio. 2023
Ryoji Miyazaki, Yoshinori Akiyama. Analyzing protein intermediate interactions in living E. coli cells using site-specific photo-crosslinking combined with chemical crosslinking. STAR protocols. 2023. 4. 2. 102178-102178
Ryoji Miyazaki, Mengting Ai, Natusko Tanaka, Takehiro Suzuki, Naoshi Dhomae, Tomoya Tsukazaki, Yoshinori Akiyama, Hiroyuki Mori. Inner membrane YfgM-PpiD heterodimer acts as a functional unit that associates with the SecY/E/G translocon and promotes protein translocation. The Journal of biological chemistry. 2022. 298. 11. 102572-102572
Yuki Imaizumi, Kazunori Takanuki, Takuya Miyake, Mizuki Takemoto, Kunio Hirata, Mika Hirose, Rika Oi, Tatsuya Kobayashi, Kenichi Miyoshi, Rie Aruga, et al. Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Science advances. 2022. 8. 34. eabp9011

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MISC (171)：

横山達彦, 塚崎智也, 秋山芳展. グラム陰性細菌において、鉄シグナル伝達を担う一回膜貫通タンパク質FecRの膜挿入・連続的切断機構の解析. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-154]
渡辺藍子, 檜作洋平, 秋山芳展, 松田憲之. YhbOのオキソアルデヒド代謝から推察するパーキンソン病原因因子DJ-1の分子機能. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-214]
石井英治, 松田重輝, 飯田哲也, 秋山芳展, 森博幸. 細菌の遺伝子発現制御の新展開ビブリオ属細菌における翻訳アレストを介した遺伝子発現制御. 日本細菌学雑誌. 2023. 78. 1. 32-32
三宅拓也, 今泉友希, 高貫一徳, 小林達也, 横山達彦, 大井里香, 檜作洋平, 禾晃和, 秋山芳展. 細菌膜内切断プロテアーゼRsePの基質取り込み・切断時におけるダイナミックな構造変化モデル. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1T07a-07
檜作洋平, 横山達彦, 三宅拓也, 小林達也, 今泉友希, 高貫一徳, 大井里香, 禾晃和, 秋山芳展. バクテリアの表層変化と生存戦略細菌パーシスター化における膜内切断プロテアーゼRsePの役割生理学的及び構造学的アプローチ. 日本細菌学雑誌. 2022. 77. 1. 19-19

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Books (3)：

Professional career (1)：

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