Rchr
J-GLOBAL ID：201401098251089874   Update date: Sep. 17, 2024

Higuchi Kei

ヒグチ ケイ | Higuchi Kei
Affiliation and department：
Tokyo University of Pharmacy and Life Sciences School of Pharmacy

About Tokyo University of Pharmacy and Life Sciences School of Pharmacy


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/10625304.ja.html
Research field  (1)： Clinical pharmacy
Research keywords  (7)： オリゴペプチド ,  アミノ酸 ,  オーファントランスポーター ,  生体内代謝物 ,  Slc6a13 ,  血液脳関門 ,  トランスポーター
Research theme for competitive and other funds  (9)：
  • 2021 - 2024 Absorption mechanism of nucleosides and their analogs in the gastrointestinal tract
  • 2021 - 2024 消化管の薬物吸収を制御する新規促進拡散型オリゴペプチドトランスポーターの分子同定
  • 2021 - 2024 Evaluation of the molecular mechanism of membrane-bound mucins in intestinal drug absorption.
  • 2017 - 2019 塩基性薬物輸送を担う血液脳関門オーファントランスポーターの機能解明
  • 2016 - 2019 Elucidation of the drug recognition properties and molecular entities of the organic cation-proton exchange system at the human blood-brain barrier
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Papers (45)：
  • Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi. Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice. Placenta. 2024. 147. 59-67
  • Koki Sugiyama, Hiroe Shimano, Masaki Takahashi, Yuta Shimura, Asuka Shimura, Takahito Furuya, Ryuto Tomabechi, Yoshiyuki Shirasaka, Kei Higuchi, Hisanao Kishimoto, et al. The Use of Carboxyfluorescein Reveals the Transport Function of MCT6/SLC16A5 Associated with CD147 as a Chloride-Sensitive Organic Anion Transporter in Mammalian Cells. Journal of Pharmaceutical Sciences. 2023
  • Keisuke Kiyomiya, Ryuto Tomabechi, Naoki Saito, Kenta Watai, Tappei Takada, Yoshiyuki Shirasaka, Hisanao Kishimoto, Kei Higuchi, Katsuhisa Inoue. Macrolide and Ketolide Antibiotics Inhibit the Cytotoxic Effect of Trastuzumab Emtansine in HER2-Positive Breast Cancer Cells: Implication of a Potential Drug-ADC Interaction in Cancer Chemotherapy. Molecular Pharmaceutics. 2023
  • Kei Higuchi, Misato Kunieda, Koki Sugiyama, Ryuto Tomabechi, Hisanao Kishimoto, Katsuhisa Inoue. Monocarboxylate Transporter 13 (MCT13/SLC16A13) Functions as a Novel Plasma Membrane Oligopeptide Transporter. Nutrients. 2023. 15. 16
  • Kaori Miyazaki, Hisanao Kishimoto, Hanai Kobayashi, Ayaka Suzuki, Kei Higuchi, Yoshiyuki Shirasaka, Katsuhisa Inoue. The GlycosylatedN-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane. Molecular Pharmacology. 2022. 103. 3. 166-175
ｍore...
MISC (38)：
  • 清宮啓介, 苫米地隆人, 齊藤直希, 渡井健太, 高田龍平, 白坂善之, 岸本久直, 樋口慧, 井上勝央. The Effect of Macrolide Antibiotics on the Cytotoxicity of Trastuzumab Emtansine. 日本薬学会年会要旨集(Web). 2024. 144th
  • 齊藤直希, 苫米地隆人, 川喜多佑香, 清宮啓介, 岸本久直, 樋口慧, 井上勝央. Exploration of genetic polymorphisms in SLC46A3 that affect the efficacy of trastuzumab emtansine. 日本薬学会年会要旨集(Web). 2024. 144th
  • 古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. Effects of Loss of P-glycoprotein of blood-brain barrier homeostasis. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th
  • 古西 修希, 伊藤 慎悟, 上村 立記, 増田 豪, 樋口 慧, 黒澤 俊樹, 手賀 悠真, 出口 芳春, 大槻 純男. ヒト脳毛細血管内皮細胞におけるP-glycoprotein欠損がプロテオームに与える変動. 電気泳動. 2019. 63. Suppl. 230-230
  • 黒澤俊樹, 手賀悠真, 樋口慧, 山口朋子, 望月達貴, 楠原洋之, 川端健二, 出口芳春. ヒトiPS由来脳毛細血管内皮細胞の薬物脳移行評価法としての有用性. 日本薬学会関東支部大会講演要旨集. 2019. 63rd
ｍore...
Lectures and oral presentations  (28)：
  • オーファントランスポーターMCT7/Slc16a6の内因性基質の同定
    (日本薬剤学会第37年会 2022)
  • SLC13A5 as a potential therapeutic target for metabolic disease and cancer
    (2021)
  • Identification of an endogenous substrate of MCT6
    (2021)
  • 気液界面を模倣する疎水性溶媒を用いた上皮系培養細胞における粘液産生と細胞形態への影響
    (日本薬剤学会第36年会 2021)
  • 薬物吸収評価を志向した新規溶剤を用いた気液界面培養法の開発
    (日本薬学会第141年会 2021)
ｍore...
Professional career (1)：
  • 博士薬学 (慶應義塾大学)
Work history (4)：
  • 2020/07 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy School of Pharmacy
  • 2018/07 - 2020/06 Texas Tech University Health Sciences Center Department of Cell Biology and Biochemistry Post Doctoral Research Associate
  • 2012/04 - 2018/06 Teikyo University Faculty of Pharma-Science
  • 2011/09 - 2012/03 Keio University
Committee career (1)：
  • 2022/04 - 現在 The Academy of Pharmaceutical Science and Technology, Japan Yakuzaigaku editorial committee
Awards (1)：
  • 2023/09 - 日本薬学会関東支部会 2023年度関東支部奨励賞 医療薬学部門 新規薬剤開発および薬物療法を目指した生体内代謝物トランスポーターの機能解析
Association Membership(s) (3)：
The Academy of Pharmaceutical Science and Technology, Japan ,  The Pharmaceutical Society of Japan ,  The Japanese Society for the Study of Xenobiotics
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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