Takeshi Yamamoto

ヤマモトタケシ | Takeshi Yamamoto

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50363122.ja.html

Research field (1)： Cardiology

Research keywords (30)：心不全 , リアノジン受容体 , 筋小胞体 , 致死的不整脈 , カルシウム , 興奮収縮連関 , 不整脈 , E-C coupling , ryanodine receptor , 内科 , 分子心臓病態学 , K201 , 心室性不整脈 , 突然変異 , calmodulin , protein phosphatase 1β , ダントロレン , 心室頻拍症 , RNAi , 悪性高熱症 , gene therapy , adeno-associated virus vector , 点突然変異 , アデノ随伴ウイルスベクター , calcium , B-type natriuretic peptide promoter , RNAi干渉 , BNP , sarcoplasmic reticulum(SR) , カルシウム循環

Research theme for competitive and other funds (30)：

2024 - 2027 妊娠初期から始めるうつ病への移行を防ぐセルフモニタリングの実証研究
2023 - 2026 心筋梗塞ハイリスク病変に対する血管小胞体Ca制御による新規プラーク安定化療法の開発
2023 - 2026 Development of novel treatment for HFpEF by correcting endoplasmic reticulum function
2022 - 2025 The cell identification research of bone marrow drived liver repaired cell in the new liver regeneration therapy
2021 - 2024 カルモジュリンの核内移行制御による新しい心不全・心肥大の治療

2020 - 2023 Treatment of heart failure, cardiac hypertrophy, and fatal arrhythmia by ryanodine receptor-bound calmodulin regulation

2020 - 2023 DASH食を用いた包括的健康行動促進プログラムの開発

2021 - 2022 カテコラミン誘発性多型性心室頻拍の発症機序解明と治療法開発

2018 - 2021 Targetting ryanodine receptors for anti-heart failure and anti-arrhythmic therapy

2018 - 2021 Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptors

2020 - 2021 リアノジン受容体結合カルモジュリン制御による新しい肺高血圧治療

2017 - 2020 Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin

2016 - 2019 Explore the new heart failure therapy focus on calmodulin translocation in cardiac myocytes

2016 - 2018 An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control

2015 - 2018 Novel therapy of arrhythmia targeting key domain in ryanodine receptor

2015 - 2018 Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmia

2014 - 2016 Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

2011 - 2013 Development of novel arrhythmia therapy using K201 binding core in RyR2 molecle

2011 - 2013 Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

2010 - 2011 Development of therapeutic therapy for regression of cardiac hypertrophy in hypertrophic cardiomyopathy

2009 - 2011 Establishment of Molecular Therapy for Severe Heart Failure and Intractable Fetal Arrhythmia

2009 - 2011 Development of novel therapeutic strategy for heart failure which targets aberrant phosphorylation status in the sarcoplasmic reticulum of failing hearts

2008 - 2010 Novel therapeutic strategy of the fatal arrhythmia targeting specific domain in the ryanodine receptor molecle

2008 - 2010 Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptor

2007 - 2008 Exploration into the Development of New Therapy for Heart Failure by Modifying Sarcoplasmic Reticulum Nanodomain Function

2006 - 2007 Establishment of molecular targeting therapy for duonic heart failure bystabilizmgryanodine receptor

2006 - 2007 Ryanodine receptor as a novel therapeutic target of lethal arrhythmia

2006 - 2007 Elucidation of molecular mechanism and treatment for abnormal ryanodine receptor in patients with malignant hyperthermia and lethal arrhythmia

2006 - 2007 拡張不全の新しいメカニズム:細胞内カルシウム過負荷とタイチンの重要性

2004 - 2005 Acquisition of resistance against heart failure by incorporation of ryanodine receptor stabilizing peptide to cardiomyocyte

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Papers (134)：

Jun Nishikawa, Yuta Tamura, Tomohiro Fujii, Soichiro Fukuda, Shoma Yoneda, Nanami Yamaura, Shinichi Takahashi, Takeshi Yamamoto, Junzo Nojima, Yutaka Suehiro, et al. Far-Ultraviolet Light at 222 nm Affects Membrane Integrity in Monolayered DLD1 Colon Cancer Cells. International journal of molecular sciences. 2024. 25. 13
T Nawata, T Honda, H Sakai, S Tsuji, M Otsuka, H Uchinoumi, S Kobayashi, T Yamamoto, M Asagiri, M Yano. Dantrolene, a ryanodine receptor stabilizer, is a candidate immunomodulator for treating rheumatic disease. Scandinavian Journal of Rheumatology. 2024. 1-3
Kaoru Yamamoto, Yasuharu Ohta, Akihiko Taguchi, Masaru Akiyama, Hiroko Nakabayashi, Yuko Nagao, Hatanaka Ryoko, Yasuaki Wada, Takeshi Yamamoto, Masafumi Yano, et al. Effects of pemafibrate on left ventricular diastolic function in patients with type 2 diabetes mellitus: a pilot study. Diabetology international. 2023. 14. 4. 434-439
Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano. RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure. Journal of molecular and cellular cardiology. 2023. 182. 25-27
Junya Nawata, Takeshi Yamamoto, Shinji Tanaka, Yasutake Yano, Tomoyuki Uchida, Shohei Fujii, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, et al. Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats. Biochemistry and biophysics reports. 2023. 34. 101449-101449

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MISC (321)：

小林茂樹, 山本健, 吉賀康裕, 岡本誉之, 矢野雅文. 心不全・致死的不整脈に対するリアノジン受容体安定化薬の臨床応用. 山口医学. 2023. 72. 3. 133-133
畠中諒子, 太田康晴, 田口昭彦, 秋山優, 山本薫, 中林容子, 永尾優子, 和田靖明, 山本健, 矢野雅文, et al. 2型糖尿病患者におけるペマフィブラードが左室拡張能へ与える影響の検討. 糖尿病. 2023. 66. 8. 618-618
畠中諒子, 太田康晴, 田口昭彦, 秋山優, 山本薫, 中林容子, 永尾優子, 和田靖明, 山本健, 矢野雅文, et al. 2型糖尿病患者におけるペマフィブラードが左室拡張能へ与える影響の検討. 糖尿病. 2023. 66. 8. 618-618
畠中諒子, 太田康晴, 田口昭彦, 秋山優, 山本薫, 中林容子, 永尾優子, 和田靖明, 山本健, 矢野雅文, et al. ペマフィブラートが2型糖尿病患者の左室拡張能に与える影響の検討. 日本内分泌学会雑誌. 2023. 99. 1. 344-344
内田智之, 小田哲郎, 山本健, 内海仁志, 末冨建, 中村吉秀, 藤井翔平, 縄田純也, 矢野泰健, 小林茂樹, et al. Impaired Calmodulin Binding Affinity to Ryanodine Receptor Drives Heart Failure with Preserved Ejection Fraction Progression(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. PJ015-6

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Patents (3)：

Lectures and oral presentations (29)：

心血管病のトランスレーショナルリサーチリアノジン受容体を分子標的とした心不全・不整脈治療
(日本循環制御医学会総会プログラム・抄録集 2019)
Ryanodine受容体安定化薬dantroleneは圧過負荷心における心不全への移行を抑制する(Dantrolene, A Ryanodine Receptor Stabilizer, Suppresses the Transition to Heart Failure in Pressure-overloaded Heart)
(日本循環器学会学術集会抄録集 2019)
DantroleneによるCaMKII-リン酸化RyR2の安定化はCaMKII δcトランスジェニックマウスにおける加齢性心筋症の発現を予防する(Stabilization of CaMKII-phosphorylated RyR2 by Dantrolene Prevents the Development of Agerelated Cardiomyopathy in CaMKII δ c Transgenic Mice)
(日本循環器学会学術集会抄録集 2019)
NAFLDに対するCa代謝調節による新規治療方法の確立のための基礎的検討
(肝臓 2018)
マウスのmonocrotaline誘発性PAHにおいてdantroleneは肺動脈圧を低下させずに右室肥大を予防する(Dantrolene Prevents Right Ventricular Hypertrophy without Reducing Pulmonary Arterial Pressure in Monocrotaline-Induced PAH in Mice)
(日本循環器学会学術集会抄録集 2018)

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Professional career (1)：

医学博士 (山口大学)

Work history (2)：

2016/04 - 現在山口大学医学(系)研究科(研究院)教授
2015 - Yamaguchi University

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