Research field (2):
Pharmaceuticals - health and biochemistry
, Pharmacology
Research keywords (5):
lipid signaling
, Amyloid beta
, vesicular transport
, Neurodegenerative disease
, Alzheimer disease
Research theme for competitive and other funds (9):
2020 - 2023 GPCR-Amyloid precursor protein supercomplex regulate neural function
2020 - 2023 小胞輸送障害の定量的・網羅的解析法の確立によるアルツハイマー病治療薬の探索
2019 - 2022 APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
2017 - 2020 Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.
2014 - 2017 Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling
2011 - 2015 Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
2009 - 2010 SPHK/S1Pシグナリングによるβセクレターゼ制御機構の解析
2007 - 2008 Substrate specific modulation of the ....secretase activity by vesicular trafficking
Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi. Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Journal of Lipid Research. 2024
Atsushi Morimoto, Nobumasa Takasugi, Yuexuan Pan, Sho Kubota, Naoshi Dohmae, Yumi Abiko, Koji Uchida, Yoshito Kumagai, Takashi Uehara. Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling. Journal of Biological Chemistry. 2024
Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara. Characterization of pathological changes in the olfactory system of mice exposed to methylmercury. Archives of Toxicology. 2024
Rikako Taniguchi, Yuto Moriya, Naoshi Dohmae, Takehiro Suzuki, Kengo Nakahara, Sho Kubota, Nobumasa Takasugi, Takashi Uehara. Attenuation of protein arginine dimethylation via S-nitrosylation of protein arginine methyltransferase 1. Journal of Pharmacological Sciences. 2023
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, et al. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nature Communications. 2023. 14. 1. 621-621