2020 - 2022 Disruption of redox status via an essential-metal and harmful-metal interaction
2019 - 2022 Investigation of the defense mechanisms by the transcription factor TCF3 against methylmercury toxicity
2019 - 2021 Methylmercury induced neuronal damage via M1-microglial activation
2015 - 2020 Molecular mechanism for toxic effect of methylmercury
2017 - 2019 Cytostatic factor that released from methylmercury exposed cells
2016 - 2019 Mechanism underlying the reduction of methylmercury toxicity by putrescine
2013 - 2016 Mechanism underlying the reduction of methylmercury toxicity by Ragulator complex which is an autophagy regulator
2012 - 2015 メチル水銀によるS-水銀化を介した心血管系障害
2010 - 2011 メチル水銀によるタンパク質の翻訳後修飾で生じる神経疾患
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Papers (57):
Xi Zheng, Takashi Toyama, Stephanie Siu, Takayuki Kaneko, Hikari Sugiura, Shota Yamashita, Yoshiteru Shimoda, Masayuki Kanamori, Kotoko Arisawa, Hidenori Endo, et al. Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage. Scientific Reports. 2024. 14. 1
Kazuhiro Nishiyama, Takashi Toyama. Supersulfides in Environmental Toxicology and Hygiene. YAKUGAKU ZASSHI. 2024. 144. 1. 39-40
Takashi Toyama, Runa Kudo, Yoshiro Saito. The Role of Supersulfide in Methylmercury Detoxification. YAKUGAKU ZASSHI. 2024. 144. 1. 41-45
Xinying Ye, Takashi Toyama, Keiko Taguchi, Kotoko Arisawa, Takayuki Kaneko, Ryouhei Tsutsumi, Masayuki Yamamoto, Yoshiro Saito. Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf2. Communications Biology. 2023. 6. 1
Yo Shinoda, Masahiro Akiyama, Takashi Toyama. Potential Association between Methylmercury Neurotoxicity and Inflammation. Biological and Pharmaceutical Bulletin. 2023. 46. 9. 1162-1168