Motoyama Noboru

モトヤマノボル | Motoyama Noboru

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/50277282.ja.html

Research field (4)： Cell biology , Nutrition and health science , Molecular biology , Medical biochemistry

Research keywords (20)： nutrigeroscience , SASP , 細胞老化 , 老化 , アポトーシス , DNA損傷 , 細胞死 , 細胞周期チェックポイント , FOXO , Chk2 , SIRT1 , p53 , ノックアウトマウス , がん抑制 , がん化 , がん抑制遺伝子 , 酸化ストレス , ミトコンドリア , 放射線 , p21

Research theme for competitive and other funds (13)：

2020 - 2023 Identificaiton of nutritional factors which suppresses SASP
2016 - 2019 Identificaiton of nutritional factors which suppress SASP
2012 - 2015 Role of SIRT1 on regulation of senescence-associated secretory phenotype during senescence
2003 - 2006 Development of therapeutic approach for progressive multifocal leukoencephalopathy using siRNA against JCV Agnogene.
2004 - 2004 Chk2によるp53活性制御とがん抑制メカニズムに関する研究

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Papers (70)：

Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, et al. MBTD1 preserves adult hematopoietic stem cell pool size and function. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2206860120
Yuki Tanoue, Takeshi Toyoda, Jinghua Sun, Md Kawsar Mustofa, Chie Tateishi, Shinya Endo, Noboru Motoyama, Kimi Araki, Di Wu, Yutaka Okuno, et al. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure. The Journal of investigative dermatology. 2018. 138. 12. 2550-2557
Dong Wan Choo, Sung Ho Goh, Young Woo Cho, Hye Jung Baek, Eun Jung Park, Noboru Motoyama, Tae Hyun Kim, Joo Young Kim, Sang Soo Kim. CHK2 is involved in the p53-independent radiosensitizing effects of valproic acid. ONCOLOGY LETTERS. 2017. 13. 4. 2591-2598
Andrea Barabino, Vicky Plamondon, Mohamed Abdouh, Wassim Chatoo, Anthony Flamier, Roy Hanna, Shufeng Zhou, Noboru Motoyama, Marc Hebert, Joelle Lavoie, et al. Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors. DEVELOPMENT. 2016. 143. 9. 1571-1584
Prashanth Gokare, Arunasalam Navaraj, Shengliang Zhang, Noboru Motoyama, Shen-Shu Sung, Niklas K. Finnberg. Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons. ONCOTARGET. 2016. 7. 20. 29520-29530

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MISC (29)：

柳野卓也, 伊藤雄貴, 日比陽子, 丸山和佳子, 本山昇. 寿命制御因子MST1によるFOXO転写活性化メカニズムの解析. 基礎老化研究. 2012. 36. 2
早川智久, 本山昇. SASP : 細胞老化と個体老化の接点. 基礎老化研究. 2011. 35. 3. 29-31
Stem cell aging theory. Anti-aging medicine. 2011. 7. 4. 549-553
Niklas K. Finnberg, Navaraj Arunasalam, Krystle Lang, George Cerniglia, Noboru Motoyama, Bin-Bing Zhou, Wafik S. El-Deiry. Pharmacologic Chk2-inhibition promotes increased killing of human colorectal cancer cells and protects from gastrointestinal toxicity following Irinotecan/trail death-receptor agonists (TDRA). CANCER RESEARCH. 2011. 71
Kazuhito Naka, Takayuki Hoshii, Yuko Tadokoro, Takako Ooshio, Yukio Kondo, Shinji Nakao, Noboru Motoyama, Atsushi Hirao. Molecular Mechanism Regulating Foxo In Leukemia Initiating Cells of Chronic Myeloid Leukemia. BLOOD. 2010. 116. 21. 1388-1388

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Work history (5)：

2015/09 - 現在 Sugiyama Jogakuen University School of Life Studies (Seikatsuka Gakubu) Department of Human Nutrition Professor
1999/02 - 2015/08 National Center for Geriatrics and Gerontrogy
1996/10 - 1999/01 Kyushu University Medical Institute of Bioregulation Associate Professor
1995/07 - 1996/09 Tokyo University of Science
1993/04 - 1995/06 Washington University School of Medicine Research Associate

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