KOMURO Akiyoshi

Affiliation and department：
Homepage URL (1)： http://biochem-kindaimed.com/

Research field (1)： Tumor biology

Research keywords (3)：がん幹細胞 , エピジェネティクス , 腫瘍生物学

Research theme for competitive and other funds (6)：

2021 - 2024 エピゲノム制御を介した転移性乳がん発生機構の解明と新規乳がん治療法の開発
2018 - 2021 Metabolic regulation and the remodeling tissue microenvironment
2018 - 2021 Role of histone demethylase in breast cancer progression and finding new therapeutic approaches for breast cancer
2014 - 2016 Inhibition of the maintenance of stemness of glioma initiating cells for clinical applications
2012 - 2014 Analysis of the maintenance of stemness of glioma initiating cells

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Papers (37)：

Masahiko Honda, Ryota Inoue, Kuniyuki Nishiyama, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Ryoichi Sugisawa, Suman Dash, Jun Shirakawa, Hitoshi Okada. Vgll2 as an integrative regulator of mitochondrial function and contractility specific to skeletal muscle. Journal of Cellular Physiology. 2024
Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Masahiko Honda, Ryoichi Sugisawa, Hitoshi Okada. Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer. Cell death & disease. 2024. 15. 2. 131-131
上田健, Dash Suman, 本多賢彦, 古室暁義, 岡田斉. 骨髄系腫瘍におけるNEDD化酵素の腫瘍抑制的な役割. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-479]
岡田斉, Dash Suman, 本多賢彦, 古室暁義, 上田健. 網羅的CRISPRライブラリースクリーニングによるIFNγ-PD-L1経路制御因子の同定. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-493]
Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada. MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance. Molecular cancer research : MCR. 2023. 21. 5. 444-457

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MISC (57)：

DASH Suman, 上田健, 古室暁義, 岡田斉. Gemcitabine-resistant PDAC cells with DCK deficiency show upregulated expression of MYC and glutamine target genes. 日本癌学会学術総会抄録集(Web). 2023. 82nd
古室暁義, 上田健, DASH Suman, 岡田斉. UTX-deficient promotes breast cancer invasion and lung metastasis. 日本癌学会学術総会抄録集(Web). 2023. 82nd
本多賢彦, DASH Suman, 古室暁義, 上田健, 岡田斉. Functional analysis of Vgll2 in the regulation of skeletal muscle oxidative capacity. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
古室暁義, 上田健, 岡田斉. The role of histone demethylase UTX in the development of invasive breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
上田健, 古室暁義, 天野恭志, 本多賢彦, 岡田斉. オンコメタボライトによる毒性を回避する機構. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-746]

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Professional career (1)：

Work history (3)：

2020/04 - 現在 Kindai University Department of Biochemistry, Faculty of Medicine
2015/04 - 2020/03 Kindai University Department of Biochemistry, Faculty of Medicine
2010 - 2015 The University of Tokyo

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