FUKUMURA Kazuhiro

Affiliation and department：
Job title： Senior Assistant Professor

Research field (2)： Molecular biology , Tumor biology

Research theme for competitive and other funds (12)：

2024 - 2027 The discovery of new essential splicing factors restructure a set of human introns
2024 - 2026 生物進化の原動力:イントロンの長大化を支えるスプライシング機構の解明
2024 - 2025 SPF45依存的スプライシングを標的とした抗がん剤耐性抑制戦略
2022 - 2025 mRNAスプライシング制御機構の破綻によって生じる抗がん剤耐性獲得メカニズムの解明と治療戦略
2023 - 2024 新規スプライシング制御因子SPF45から探る抗がん剤耐性獲得機構の解明

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Papers (17)：

Kazuhiro Fukumura, Luca Sperotto, Stefanie Seuß, Hyun-Seo Kang, Rei Yoshimoto, Michael Sattler, Akila Mayeda. SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns. Cell reports. 2023. 42. 113534
Kazuhiro Fukumura, Akio Masuda, Jun-ichi Takeda, Osamu Nagano, Hideyuki Saya, Kinji Ohno, Akila Mayeda. RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle. bioRxiv 2023.11.20.567984; doi: https://doi.org/10.1101/2023.11.20.567984. 2023
Hiroaki Nagamine, Masakazu Yashiro, Naoki Yoshimoto, Motohiro Izumi, Akira Sugimoto, Kenji Nakahama, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Yoko Tani, et al. RBM17 Expression Is Associated With the Efficacy of ICI Monotherapy in NSCLC With Low PD-L1 Expression. Anticancer research. 2023. 43. 10. 4663-4672
Kazuhiro Fukumura, Luca Sperotto, Stefanie Seuß, Hyun-Seo Kang, Rei Yoshimoto, Michael Sattler, Akila Mayeda. SAP30BP interacts with RBM17/SPF45 to promote splicing in a subset of human short introns. bioRxiv doi: https://doi.org/10.1101/2022.12.30.522300. 2022
Kazuhiro Fukumura, Julian P. Venables, A. Mayeda. SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy. MOLECULAR & CELLULAR ONCOLOGY. 2021

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Books (5)：

Lectures and oral presentations (30)：

RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle
(The 29th Annual Meeting of the RNA Society 2024)
SAP30BP-RBM17 interaction is an essential process to splice out a subset of human short introns
(2023)
Identified RBM17 (SPF45)-SAP30BP interaction promotes non- canonical splicing in a subset of human short introns.
(The 28th Annual Meeting of the RNA Society 2023)
Splicing in a subset of human short introns is promoted by SAP30BP- RBM17 but not by canonical U2AF2-U2AF1
(2023)
RNPS1 in PSAP complex controls precise pre-mRNA splicing with periodicity during cell cycle
(2022)

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Education (1)：

2006 - 2009 Kobe University Graduate School of Science and Technology Department of Biosystems Science

Professional career (1)：

Work history (6)：

2024/04 - 現在 Fujita Health University Oncology Innovation Center Senior Assistant Professor
2021/10 - 2024/03 藤田医科大学医科学研究センター遺伝子発現機構学研究部門講師
2015/08 - 2021/09 藤田保健衛生大学(現藤田医科大学) 総合医科学研究所(現医科学研究センター) 遺伝子発現機構学助教
2012/11 - 2015/07 Life Technologies Ltd. (Thermo Fisher Scientific Inc.) Field Application Scientist
2011/04 - 2012/10 Kobe University Faculty of Science, Department of Biology

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Awards (2)：

Association Membership(s) (3)：

THE RNA SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本癌学会

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