Rchr
J-GLOBAL ID：201501009602866222   Update date: Jan. 30, 2024

Yasutoshi Koga

コガ ヤストシ | Yasutoshi Koga
Affiliation and department：
Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine

About Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine


Job title： Emeritus Professor
Homepage URL  (1)： https://kaken.nii.ac.jp/d/r/00225400.ja.html
Research field  (4)： Medical biochemistry ,  Neurology ,  Fetal medicine/Pediatrics ,  Cardiology
Research keywords  (30)： ミトコンドリアDNA ,  点変異 ,  ミトコンドリア脳筋症 ,  電子伝達系酵素 ,  MELAS ,  ミトコンドリアtRNA ,  一酸化窒素 ,  ミトコンドリア病 ,  Leigh脳症 ,  ミトコンドリア ,  RNA 19 ,  エネルギー代謝 ,  電子伝達系酵素欠損症 ,  ミトコンドリア脳卒中 ,  母系遺伝 ,  シナジー効果 ,  核DNA ,  PCR ,  KOマウスモデル ,  早老症 ,  エネルギー不全 ,  エネルギー産生系異常 ,  ミトコンドリア心筋症 ,  臓器特異性 ,  Klotho遺伝子 ,  KOマウス ,  Leitg脳症 ,  RNAプロセッシング ,  プロセッシング ,  ragged-red fibers
Research theme for competitive and other funds  (31)：
  • 2018 - 2021 Therapeutic approach for metabolic syndrome using GDF15
  • 2014 - 2019 Development of therapeutic drug of sodium pyruvate for mitochondrial disorders
  • 2016 - 2018 Confounding factor for GDF15 and FGF21
  • 2011 - 2018 Molecular pathogenesis of mitochondrial disorders
  • 2013 - 2016 Development of diagnostic biomarker of mitochondrial disorders
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Papers (123)：
  • Arinaga-Hino T, Ide T, Akiba J, Suzuki H, Kuwahara R, Amano K, Kawaguchi T, Sano T, Inoue E, Koga H, et al. Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis. Sci Rep. 2022. 24. 12. 8759
  • Kojima-Ishii Kanako, Nana Sakakibara, Kei Murayama, Koji Nagatani, Satoshi Murata, Akira Otake, Yasutoshi Koga, Hisato Suzuki, Tomoko Uehara, Kenjiro Kosaki, et al. BCS1L mutations produce Fanconi syndrome with developmental disability. Journal of human genetics. 2022. 67. 3. 143-148
  • Amel Karaa, Laura E MacMullen, John C Campbell, John Christodoulou, Bruce H Cohen, Thomas Klopstock, Yasutoshi Koga, Costanza Lamperti, Rob van Maanen, Robert McFarland, et al. Community Consensus Guidelines to Support FAIR Data Standards in Clinical Research Studies in Primary Mitochondrial Disease. Advanced genetics (Hoboken, N.J.). 2022. 3. 1
  • Tomoko Kashiki, Jun Kido, Ken Momosaki, Shouichirou Kusunoki, Shiro Ozasa, Keiko Nomura, Atsuko Imai-Okazaki, Tomoko Tsuruoka, Kei Murayama, Yasutoshi Koga, et al. Mitochondrial DNA depletion syndrome with a mutation in SLC25A4 developing epileptic encephalopathy: A case report. Brain & development. 2022. 44. 1. 56-62
  • Masahiro Kinoshita, Shuichi Yatsuga, Osuke Iwata, Hisayoshi Okamura, Toshihiro Morisaki, Sachiko Iwata, Naoko Hara, Ryota Shindo, Mamoru Saikusa, Eimei Harada, et al. Temporal changes and control variables of growth differentiation factor 15 levels during the first week of life in hospitalised newborn infants. Mitochondrion. 2021. 61. 25-30
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MISC (339)：
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Patents (2)：
Education (2)：
  • 1980 - 1984 Kurume University Graduate School of Medicine Graduate School of Medicine Ph.D.
  • 1974 - 1980 Kurume University School of Medicine Medical Doctor
Professional career (1)：
  • M.D., Ph.D. (Kurume University)
Work history (9)：
  • 2022/05 - 現在 Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine Emeritus Professor
  • 2021/04 - 現在 Cognitive and Molecular Research Institute of Brain Diseases, Kurume University School of Medicine Pediatrics Visiting Professor
  • 2004/04 - 2021/03 Kurume University Department of Pediatrics and Child Health, Kurume University School of Medicine Full Profesor
  • 2001/04 - 2004/03 Kurume University Department of Pediatrics and Child Health, Kurume University School of Medicine associate professor
  • 1994/04 - 2001/03 Kurume University Department of Pediatrics and Child Health, Kurume University School of Medicine assistant professor
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Committee career (6)：
  • 2018/10 - 現在 アジアミトコンドリア学会 プレジデント
  • 2016/04 - 現在 JSPS 文部科学研究費二次審査委員
  • 2014/10 - 現在 日本ミトコンドリア学会 理事
  • 2007/04 - 現在 日本小児神経学会 薬事委員
  • 2005/04 - 現在 日本小児科学会 代議員
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Awards (9)：
  • 2016/06 - UMDF Kelsey Wright Award mitochondrial new biomarker GDF15
  • 2011/06 - European Neuromuscular conference Best research award L-arginine therapy for MELAS
  • 2008/10 - Japanese Society of Mitochondrial Research and Medicine Best research award L-arginine therapy for MELAS
  • 2008/06 - UMDF Kelsey Wright Award L-arginine therapy for MELAS
  • 2003/10 - Uehara Memorial Foundation Research awards Molecular basis of mitochondrial disorders
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Association Membership(s) (4)：
THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE ,  JAPANESE SOCIETY FOR INHERITED METABOLIC DISEASES ,  The Japanese Society Of Child Neurology ,  JAPAN PEDIATRIC SOCIETY
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