Rchr
J-GLOBAL ID：201501009998442153   Update date: Nov. 14, 2024

Arakawa Hiroshi

アラカワ ヒロシ | Arakawa Hiroshi
Affiliation and department：
Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy

About Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy


Job title： Associate Professor
Research field  (1)： Clinical pharmacy
Research keywords  (2)： Drug-induced kidney injury ,  Pharmacokinetics
Research theme for competitive and other funds  (21)：
  • 2023 - 2026 三次元培養ヒト近位尿細管上皮細胞を用いた薬物誘発性腎障害in vitro評価手法の開発
  • 2023 - 2026 薬物代謝反応に及ぼす小胞体膜輸送体の役割解明
  • 2023 - 2025 尿酸結合タンパク質CD38を介した尿酸による炎症応答調節
  • 2022 - 2025 Construction of evaluation system for in vitro drug biliary excretion
  • 2022 - 2024 CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定
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Papers (76)：
  • Shijie Wen, Hiroshi Arakawa, Shigeru Yokoyama, Yoshiyuki Shirasaka, Haruhiro Higashida, Ikumi Tamai. Functional identification of soluble uric acid as an endogenous inhibitor of CD38. eLife. 2024. 13
  • Hanyuan Wang, Mathieu Danoy, Ya Gong, Tia Utami, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, Yasuyuki Sakai, Eric Leclerc. Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte-Like Cells Derived From Human-Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip. Journal of applied toxicology : JAT. 2024
  • Masaya Ueno, Hiroki Sugiyama, Feng Li, Tatsuya Nishimura, Hiroshi Arakawa, Xi Chen, Xiaoxiao Cheng, Shinji Takeuchi, Yumie Takeshita, Toshinari Takamura, et al. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Analytical chemistry. 2024. 96. 36. 14499-14507
  • Hiroshi Arakawa, Daichi Higuchi, Etsushi Takahashi, Kohei Matsushita, Shiho Nedachi, Hanwei Peng, Moeno Kadoguchi, Kaoru Morimura, Ayano Araki, Masayuki Kondo, et al. Three-dimensional Culture of Human Proximal Tubular Epithelial Cells for an in vitro Evaluation of Drug-induced Kidney Injury. Journal of pharmaceutical sciences. 2024
  • Natsuko Ishida, Ayano Katsura, Koichi Takagaki, Hiroshi Arakawa, Tsutomu Shimada, Satoshi Mizuno, Yoshimichi Sai, Yukio Kato, Hiroyuki Nakamura, Yukio Suga, et al. Transdermal pilocarpine on the skin over salivary glands to increase salivation: an in vivo study. BMC oral health. 2024. 24. 1. 881-881
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MISC (19)：
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Books (2)：
  • 個別化医療を目指した臨床薬物動態学 1(基礎編)
    広川書店 2016
  • 個別化医療を目指した臨床薬物動態学 2(治療薬物モニタリング編)
    広川書店 2016
Lectures and oral presentations  (24)：
  • Utility of high content analysis for an in vitro evaluation of drug-induced kidney injury
    (2024)
  • 腸肝連結microphysiological systemを用いた薬物動態の臓器間相互作用解析
    (第26回日本神経消化器病学会 2024)
  • In Vitro Evaluation Methods for Hepatic and Renal Drug Disposition and Toxicity
    (2024 ISSX/JSSX Meeting 2024)
  • 胆汁成分が回収可能な肝細胞培養系icHepを用いた薬物胆汁排泄評価
    (第 31 回肝細胞研究会 2024)
  • オルガノイド培養を用いた薬物動態・毒性評価の新展開
    (第51回日本毒性学会学術年会 2024)
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Education (2)：
  • 2013 - Graduate School of Kanazawa University Graduate School of Natural Science and Technology Divisions of Life Science
  • - 2007 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
  • PhD (Kanazawa University)
Work history (4)：
  • 2021/02 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Assciate Professor
  • 2018/04 - 現在 Kanazawa University Cancer Research Institute
  • 2016/02 - 2021/01 Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences Assitant Professor
  • 2013/04/01 - 2016/01/31 Takasaki University of Health and Wealfare Faculty of Pharmacy Assitant Professor
Awards (6)：
  • 2024/05 - 日本薬剤学会 奨励賞 生体環境を模倣する新規細胞培養技術の薬物動態・毒性研究への応用に関する研究
  • 2023/09 - 2023 International Joint Meeting of ICCP450/JSSX JSSX Best Poster Award Utility of high content analysis of drug-induced kidney injury using 3D-cultured kidney epithelial cells
  • 2022/11 - 日本動物実験代替法学会 第35回大会 大会長特別賞 三次元培養ヒト初代近位尿細管上皮細胞を用いた薬物腎毒性の評価手法の構築
  • 2022/11 - The Japanese Society for the Study of Xenobiotics (JSSX) JSSX Award for Young Scientists Development of novel pharmacokinetic evaluation systems through collaboration research between pharmaceutical science and bioengineering
  • 2021/11 - Award for Young Scientists
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Association Membership(s) (7)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Society for Pharmacology and Experimental Therapeutics (ASPET) ,  JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM ,  The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) ,  The Japanese Society for the Study of Xenobiotics (JSSX) ,  International Society for the Study of Xenobiotics ,  The Japanese Society for Alternatives to Animal Experiments
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