Rchr
J-GLOBAL ID：201501009998442153   Update date: May. 17, 2024

Arakawa Hiroshi

アラカワ ヒロシ | Arakawa Hiroshi
Affiliation and department：
Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy

About Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy


Job title： Associate Professor
Research field  (1)： Clinical pharmacy
Research keywords  (2)： Drug-induced kidney injury ,  Pharmacokinetics
Research theme for competitive and other funds  (21)：
  • 2023 - 2026 三次元培養ヒト近位尿細管上皮細胞を用いた薬物誘発性腎障害in vitro評価手法の開発
  • 2023 - 2026 薬物代謝反応に及ぼす小胞体膜輸送体の役割解明
  • 2023 - 2025 尿酸結合タンパク質CD38を介した尿酸による炎症応答調節
  • 2022 - 2025 Construction of evaluation system for in vitro drug biliary excretion
  • 2022 - 2024 CKD予防・治療手法の提唱を目指した尿毒症物質の腎毒性トリガータンパク質の同定
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Papers (67)：
  • Rikako Imamura, Masahiro Sugimoto, Shin-ichi Horike, Jumpei Terakawa, Kazuki Fujita, Ikumi Tamai, Takiko Daikoku, Yukio Kato, Hiroshi Arakawa. Role of organic anion transporter NPT4 in renal handling of uremic toxin 3-indoxyl sulfate. Journal of Pharmaceutical Sciences. 2024
  • Benedikt Scheidecker, Stéphane Poulain, Masahiro Sugimoto, Taketomo Kido, Takumi Kawanishi, Atsushi Miyajima, Soo Hyeon Kim, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, et al. Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro. Biofabrication. 2024. 16. 2. 025037-025037
  • Shijie Wen, Hiroshi Arakawa, Ikumi Tamai. Uric acid in health and disease: From physiological function to pathogenic mechanism. Pharmacology & therapeutics. 2024. 108615-108615
  • Dhimas Agung Kurniawan, Sylvia Leo, Mutsumi Inamatsu, Sohei Funaoka, Taichi Aihara, Mizuno Aiko, Inoue Rei, Takeshi Sakura, Hiroshi Arakawa, Yukio Kato, et al. Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. PNAS Nexus. 2024
  • Kiyoshi Hashimoto, Hiroshi Arakawa, Rikako Imamura, Takuya Nishimura, Satoshi Kitajima, Takuya Sato, Kazuhide Makiyama, Takehiko Ogawa, Satoshi Yokota. A novel alternative method for long-term evaluation of male reproductive toxicity and its recovery using a pre-pubertal mouse testis organ culture system. Journal of applied toxicology : JAT. 2024
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MISC (19)：
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Books (2)：
  • 個別化医療を目指した臨床薬物動態学 1(基礎編)
    広川書店 2016
  • 個別化医療を目指した臨床薬物動態学 2(治療薬物モニタリング編)
    広川書店 2016
Lectures and oral presentations  (16)：
  • InnoCellTM Tプレートを用いた腎組織スライス初代培養法の樹立と薬物腎毒性評価における有用性
    (第2回新規Cell Based Assay ワーキンググループ研究会 2023)
  • 薬物動態の臓器間相互作用の解明を目的とした肝・腎細胞培養手法の構築
    (第46回日本分子生物学会年会 2023)
  • 薬物トランスポーターを考慮した薬物安全性評価を可能とする肝・腎細胞培養手法の構築
    (第9回AMEDレギュラトリーサイエンス公開シンポジウム 2023)
  • Endoplasmic reticulum membrane transporter OAT2 regulates hepatic drug metabolism
    (2023 International Joint Meeting of 23rd ICCP450/38th JSSX 2023)
  • 透過試験による薬物胆汁中排泄評価が可能なヒト肝細胞培養手法の構築
    (第50回日本毒性学会学術年会 2023)
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Education (2)：
  • 2013 - Graduate School of Kanazawa University Graduate School of Natural Science and Technology Divisions of Life Science
  • - 2007 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Pharmacy
Professional career (1)：
  • PhD (Kanazawa University)
Work history (4)：
  • 2021/02 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Assciate Professor
  • 2018/04 - 現在 Kanazawa University Cancer Research Institute
  • 2016/02 - 2021/01 Kanazawa University Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Sciences Assitant Professor
  • 2013/04/01 - 2016/01/31 Takasaki University of Health and Wealfare Faculty of Pharmacy Assitant Professor
Awards (5)：
  • 2023/09 - 2023 International Joint Meeting of ICCP450/JSSX JSSX Best Poster Award Utility of high content analysis of drug-induced kidney injury using 3D-cultured kidney epithelial cells
  • 2022/11 - 日本動物実験代替法学会 第35回大会 大会長特別賞 三次元培養ヒト初代近位尿細管上皮細胞を用いた薬物腎毒性の評価手法の構築
  • 2022/11 - The Japanese Society for the Study of Xenobiotics (JSSX) JSSX Award for Young Scientists Development of novel pharmacokinetic evaluation systems through collaboration research between pharmaceutical science and bioengineering
  • 2021/11 - Award for Young Scientists
  • 2011/04 - 4th Asia Pacific Regional ISSX Meeting 4th APISSX Best Presentation Award, 1st Place Upregulation of organic anion transporting polypeptide (OATP) 1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer
Association Membership(s) (7)：
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Society for Pharmacology and Experimental Therapeutics (ASPET) ,  JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM ,  The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) ,  The Japanese Society for the Study of Xenobiotics (JSSX) ,  International Society for the Study of Xenobiotics ,  The Japanese Society for Alternatives to Animal Experiments
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