Research field (9)：
Respiratory surgery
, Cardiovascular surgery
, Biomaterials
, Biomedical engineering
, Fetal medicine/Pediatrics
, Digestive surgery
, Respiratory medicine
, General surgery, pediatric surgery
, Experimental pathology
Research theme for competitive and other funds (89)：
2021 - 2024 心筋再生療法のメカニズム究明のための心筋ミトコンドリア機能のイメージング
2020 - 2023 Creating "3D mini heart" for transplantation of heart failure
2017 - 2021 Safety and Effectiveness of Stentless Mitral Valve for Mitral Stenosis
2016 - 2018 Development of heart failure treatment by new device using extracellular matrix modulating cardiac stem cell niche
2015 - 2018 Study of drug discovery using cardiomyocytes derived from iPS cells in cardiovascular diseases
2014 - 2016 Development of the treatment of cardiac failure using a nanosphere (NS) preparation encapsulated with a therapeutic agent for myocardial regeneration
2011 - 2016 Creation of Functional Materials Using Polymer Self Assembly and Biomedical Application
2012 - 2015 The development of surgical treatment targeting myocardial stiffness in damaged myocardium
2012 - 2014 Developing microRNA research in cardiac failure
2011 - 2014 Developement of a new stentless mitral valve for clinical application
2011 - 2014 Across-the-board study for treatment strategy of type B aortic dissection
2010 - 2013 アディポネクチン産生細胞シートを用いた新規大動脈瘤治療に関する研究
2011 - 2012 Potential of microRNA as a biomarker for atherosclerotic aortic aneurysm
2011 - 2012 Development of new treatment of heart failure using induced pluripotent stem cells-derived cardiomyocytes
2011 - 2012 Analysis of relationship between microRNA expression and atrial fibrillation for development of new treatment
2011 - 2012 Development of cardiac regenerative medicine using a novel human somatic stem cell (Muse cell)
2010 - 2012 The development of novel therapy combined LVAD and regenerative medicine for severe heart failure patients
2010 - 2011 Development and the clinical application of the caqrdiovascular operation support program applied hydrodynamics simulation
2010 - 2011 Development of Targeted Adiponectin Delivery System by Using Induced Adipocyte Cell-sheet
2009 - 2011 Development of new stent graft system using whole aortic navigation
2009 - 2011 Introduction of new strategy for end-stage heart failure by implantable ventricular assist device aiming to long-term-support with reintegration into society : Survey for the background and possible candidates.
2009 - 2011 Developing a novel regenerative treatment for cardiac failure by using iPS cell-derived self-cardiac tissue
2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors
2009 - 2011 Development of the new carrier device for sever heart failure using apoptotic cell-mimetic liposome
2009 - 2010 自己間葉系幹細胞由来細胞シート移植による自己組織化心筋再生治療法の開発
2008 - 2010 Key factors for cardiac recovery in patients with left ventricular assist device for end stage heart failure
2007 - 2008 Novel treatment strategy for the chronic emphysema aiming for regeneration of the lung by collaboration between medicine and engineering research.
2007 - 2008 A structured endoscopic surgical training program designed for rotating residents
2007 - 2008 Myocardial Regeneration Therapy Using Autologous Cell Sheet
2007 - 2008 Research on the application of "fluctuation in bioligical system" to a new generation artificial heart.
2007 - 2008 Therapeutic effect of growth factor enhancement of cardiacregeneration on cardiac remodeling in infarcted rat hearts
2007 - 2008 Development of novel scaffold for cardiac regeneration
2006 - 2008 Identification and therapeuticeffect of growth factor inducingmyoblast sheet transplantation in infarcted rat hearts
2005 - 2006 Minimally-immunogenic Decellularized Porcine Valve Provides In-situ Recellularization in a Stentless Bioprosthetic Valve
2005 - 2006 Establishment of Regenerative Therapy for Patients with Left Ventricular Assist Device 〜Aiming to 'Bridge to Recovery〜
2004 - 2005 ESTABLISHMENT OF MULTIORGAN PROCUREMENT SYSTEM FROM NO-HEART-BEATING DONOR USING PERCUTANEOUS CARDIOPULMONARY BYPASS
2004 - 2005 Development of Myocardial Regenerative Therapy using Highly Regular Honeycomb-Patterned Scaffold inducing tissue self-regeneration
2003 - 2005 A study for the induction of transplantation tolerance using adenovirus expressing PD-1 ligands and application to myoblast transplantation into infarcted hearts.
2003 - 2005 Myocardial regeneration therapy using nanotechnology enhances self-regeneration in damaged myocardium
2003 - 2004 遺伝子工学・細胞組織工学を応用した拡張型心筋症の新しい治療法の確立
2003 - 2004 自己骨格筋由来拍動細胞による心筋再生治療法の確立
2003 - 2004 Development of a new bioengineered patch for promoting in situ cellularization and the regeneration of autologous tissue in cardiovascular surgery
2003 - 2004 Protective effect on inhalated carbon monoxide for multiple organ dysfunction at cardiovascular surgery
2003 - 2004 Establishment of totally endoscopic cardiac surgery using ZEUS surgical system
2002 - 2003 ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION
2002 - 2003 The combined use of HGF gene therapy and ventricular assist device improves left ventricular function and enables bridge to recovery in goat model of severe heart failure
2001 - 2002 心筋細胞・細胞外基質間相互作用に着目した心筋症メカニズムの解明
2001 - 2002 Biological monitoring of immunological modifications in patients supported with left ventricular assist system
2001 - 2002 An experimental study to detect unknown or unexpected genes expressed in the developmental phase of transplant vasculopathy.
2001 - 2002 Development of novel myocardial regeneration therapy for severe heart failure using cellular cardiomyoplasty and gene transfection
2001 - 2002 低侵襲性を求めた完全内視鏡下心臓手術法の確立
2000 - 2001 An experimental study developing new therapeutic strategy for cardiac allograft vasculopathy : selective chemokine/receptor systems as molecular targets
2000 - 2001 ESTABLISHMENT OF NEW IMMUNOSUPPRESSIVE STRATEGY USING GENE TRANSFECTION TECHNIQUE
1999 - 2000 A study searching for new genes in chronic cardiac rejection using PCR-based differential display.
1999 - 2000 A new strategy for brain protection during circulatory arrest
1999 - 2000 Researches on novel techniques of organ-selective gene therapy in thoracic surgery
1999 - 2000 ESTABLISHMENT OF IMMUNOSUPPRESIVE METHOD FOR CLINICAL DISCORDANT XENOGENEIC CARDIAC TRANSPLANTATION
1998 - 2000 A study of molecular diagnosis and treatment for chronic cardiac allograft rejection.
1998 - 2000 Ex vivo expansion system of hematopoietic progenitors utilizing genetic engineering
1998 - 1999 プラズマ放電処理を利用したハイブリッド型人工肺構築
1998 - 1999 Development of biocompatible, next-generation cardiopulmonary bypass system
1998 - 1999 ESTABLISHMENT OF NEW IMMUNOSUPPRESSIVE STRATEGY USING GENE TRANSFECTION TECHNIQUE
1998 - 1999 Anovel strategy for heart disease using gene therapy
1998 - 1999 Development of gene therapy to myocardium using transvenous gene transfection method.
1997 - 1998 Development of the gene therapy against the organ dysfunction in the patients under LVAS support.
1997 - 1998 Novel clinical strategy for thoracic anerysm using intra/extra vascular stenting and molecular biological drug delivery system.
1996 - 1997 体外循環を用いない心房細動根治術(pumpless Maze)の開発
1996 - 1997 Prevention of hypoxic brain damage by in vivo transfection through the carotid artery in cirsulatory arrest
1996 - 1997 A novel gene therapy for congestive heart failure.
1996 - 1997 Mechanism od Cardiac Hypertrophy ; The Efficacy of Gene Therapy in Cardiac Hypertrophy
1996 - 1997 The study elucidating the molecular mechanisms underlying transplant vasculopathy
1996 - 1996 遺伝子導入を用いた肺高血圧症の病態解析と治療に関する研究
1995 - 1996 Study of newly developed cardioplegia for long term myocardial preservation
1995 - 1996 Deveropment of Cryopreseaved Allograft with Gene Introduction
1994 - 1996 A novel myocardial protection with in vivo gene transfection
1994 - 1995 Analysis for the mechanism of graft coronary arteriosclerosis
1994 - 1995 The Research for Regulation of Vascular Stenosis by Antisense Delivery System
1994 - 1995 ESTABLISHMENT OF IMMUNOSUPPRRESIVE METHOD FOR CLINICAL XENOTRANSPLANTATION
1993 - 1994 NEW METHOD FOR MYOCARDIAL PROTECTION
1993 - 1994 New myocardial motection with cytokine network.
1992 - 1993 The mechanisms of pulmonary arterial venous fistula in the cases of Fontan type operation
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Papers (1,258)：
Junjun Li, Menglu Li, Yasunori Nawa, Yuting Liu, Kazuki Bando, Ying Hua, Lifu Sun, Satoshi Fujita, Yoshiki Sawa, Katsumasa Fujita, et al. Label-Free Raman Spectroscopy for Assessing Purity and Maturation of hiPSC-Derived Cardiac Tissue. Analytical Chemistry. 2024. 96. 39. 15765-15772
Takashi Nishimura, Yasutaka Hirata, Takayuki Ise, Hiroyuki Iwano, Hironori Izutani, Koichiro Kinugawa, Takeshi Kitai, Takayuki Ohno, Tomohito Ohtani, Takahiro Okumura, et al. JCS/JSCVS/JCC/CVIT 2023 guideline focused update on indication and operation of PCPS/ECMO/IMPELLA. Journal of cardiology. 2024. 84. 3. 208-238
Takashi Nishimura, Yasutaka Hirata, Takayuki Ise, Hiroyuki Iwano, Hironori Izutani, Koichiro Kinugawa, Takeshi Kitai, Takayuki Ohno, Tomohito Ohtani, Takahiro Okumura, et al. JCS/JSCVS/JCC/CVIT 2023 Guideline Focused Update on Indication and Operation of PCPS/ECMO/IMPELLA. Circulation journal : official journal of the Japanese Circulation Society. 2024
Kenichiro Shimatani, Hiromu Sato, Kazuhiko Mizukami, Atsuhiro Saito, Masao Sasai, Jun-Ichiro Enmi, Kenichi Watanabe, Masazumi Kamohara, Yoshichika Yoshioka, Shigeru Miyagawa, et al. Transplantation of Human Embryonic Stem Cell-Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia. Journal of Cardiovascular Translational Research. 2024
Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, et al. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment. iScience. 2024. 27. 2. 108992-108992
