Shigeru Miyagawa

ミヤガワシゲル | Shigeru Miyagawa

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://kaken.nii.ac.jp/d/r/70544237.ja.html

Research field (2)： Respiratory surgery , Cardiovascular surgery

Research keywords (30)： iPS細胞 , 心不全 , 再生医療 , 再生医学 , 人工心臓 , 幹細胞 , 心不全薬 , トランスレーショナルリサーチ , 機械的刺激 , 心筋分化 , 移植・再生医療 , 左室形成デバイス , 細胞・組織 , 心筋梗塞 , 心筋再生 , 細胞移植 , 細胞シート , Muse細胞 , 心筋細胞 , micro RNA , アディポネクチン , 心房細動 , Drug delivery system , シミュレーション , 難治性疾患 , 血流評価 , 拡張能 , プロスタグランジン製剤 , 腹部大動脈瘤 , 拒絶反応

Research theme for competitive and other funds (33)：

2022 - 2025 脂肪細胞由来幹細胞exosomeを用いた新規cell-free心筋再生療法の開発
2022 - 2025 Novel regenerative therapy for liver failure with skeletal myoblast cell sheet transplantation
2022 - 2025 制御性T細胞を用いた移植免疫制御方法の開発
2021 - 2024 Effects of nutrition, aging, and stem cell against inflammation on high-risk heart disease, and evaluation of tissue regeneration ability.
2021 - 2024 心筋再生療法のメカニズム究明のための心筋ミトコンドリア機能のイメージング

2015 - 2019 Metabolic profiling of reverse remodeling and cardiac recovery in end-stage congestive hart failure

2015 - 2018 Overcoming ischemic cardiomyopathy by angiogenic drugs

2015 - 2018 The impact of transplantation of cardiomyocyte sheet derived from MHC homozygous induced pluripotent stem cells

2015 - 2018 Degenerative therapy for heart failure using skeletal muscle cell-extracellular matrix interaction.

2015 - 2018 Study of drug discovery using cardiomyocytes derived from iPS cells in cardiovascular diseases

2015 - 2017 iPSC derived three dimensional cardiac tissue having circulatory system

2014 - 2017 Development of immune tolerance method for clinical application of allogeneic iPS cells

2014 - 2017 Engineeing of the heart tissues using decellularized extracellular matrix - Development of basic technology to construct three-dimensional organ-like tissues

2013 - 2015 In vivo and vitro noble differentiation of induced pluripotent stem cell derived cardiomyocytes

2013 - 2015 Investigation for immune tolerace of allogeneic induced pluripotent stem cell-derived cardiomyocyte

2012 - 2015 The development of novel therapeutic strategy for pediatric heart failure patients using ventricular assist devices and cardiac regnerative therapy.

2012 - 2015 Degenerative therapy for heart failure using autologous myocardial fibroblast.

2012 - 2015 The development of surgical treatment targeting myocardial stiffness in damaged myocardium

2012 - 2014 Developing microRNA research in cardiac failure

2010 - 2013 アディポネクチン産生細胞シートを用いた新規大動脈瘤治療に関する研究

2011 - 2012 Development of new treatment of heart failure using induced pluripotent stem cells-derived cardiomyocytes

2011 - 2012 Analysis of relationship between microRNA expression and atrial fibrillation for development of new treatment

2011 - 2012 Development of cardiac regenerative medicine using a novel human somatic stem cell (Muse cell)

2010 - 2012 The development of novel therapy combined LVAD and regenerative medicine for severe heart failure patients

2010 - 2011 Development and the clinical application of the caqrdiovascular operation support program applied hydrodynamics simulation

2010 - 2011 Development of Targeted Adiponectin Delivery System by Using Induced Adipocyte Cell-sheet

2009 - 2011 Development of new stent graft system using whole aortic navigation

2009 - 2011 Developing a novel regenerative treatment for cardiac failure by using iPS cell-derived self-cardiac tissue

2009 - 2011 Development of the new cell-free device for sever heart failure by restructuring of artificial stem cell niche using extracellular matrixes and stem cell recruitment/differentiation factors

2009 - 2011 Development of the new carrier device for sever heart failure using apoptotic cell-mimetic liposome

2007 - 2008 Therapeutic effect of growth factor enhancement of cardiacregeneration on cardiac remodeling in infarcted rat hearts

2007 - 2008 Development of novel scaffold for cardiac regeneration

2006 - 2008 Identification and therapeuticeffect of growth factor inducingmyoblast sheet transplantation in infarcted rat hearts

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Papers (487)：

Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Lifu Sun, Akima Harada, Ying Hua, Nagako Sougawa, Akiko Tabata, Li Liu, et al. Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction. Bioactive Materials. 2024. 37. 533-548
Keisuke Toya, Yoshito Tomimaru, Shogo Kobayashi, Kiyokazu Nakajima, Akima Harada, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, et al. Application of a laparoscopic device for cell-derived sheet transplantation on the liver in a porcine model. Minimally Invasive Therapy & Allied Technologies. 2024. 1-7
Renjie Wang, Moyu Hasegawa, Hidehiro Suginobe, Chika Yoshihara, Yoichiro Ishii, Atsuko Ueyama, Kazutoshi Ueda, Kazuhisa Hashimoto, Masaki Hirose, Ryo Ishii, et al. Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy. Journal of the American Heart Association. 2024. 13. 6. e032375
Kenichiro Shimatani, Hiromu Sato, Kazuhiko Mizukami, Atsuhiro Saito, Masao Sasai, Jun-Ichiro Enmi, Kenichi Watanabe, Masazumi Kamohara, Yoshichika Yoshioka, Shigeru Miyagawa, et al. Transplantation of Human Embryonic Stem Cell-Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia. Journal of Cardiovascular Translational Research. 2024
Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, et al. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment. iScience. 2024. 27. 2. 108992-108992

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MISC (520)：

小津賢太郎, 岡崇史, 中野智彰, 関原孝之, 中村大輔, 溝手勇, 大谷朋仁, 彦惣俊吾, 宮川繁, 坂田泰史. 心再同期療法左室リードの閾値上昇に対し心外膜リード留置を施行した1例. 植込みデバイス関連冬季大会プログラム・抄録集(Web). 2023. 15th
伊藤仁人, 河村拓史, 吉岡大輔, 川村匡, 松浦良平, 河村愛, 三隅祐輔, 千村美里, 渡部直史, 平将生, et al. 虚血性心筋症に対する自己筋芽細胞パッチ移植におけるNH3-PETによる冠血流評価とTc-99m MIBIシンチグラフィーによるミトコンドリア機能評価. 日本胸部外科学会定期学術集会(Web). 2023. 76th
伊藤仁人, 河村拓史, 吉岡大輔, 川村匡, 松浦良平, 河村愛, 三隅祐輔, 千村美里, 平将生, 島村和男, et al. 虚血性心筋症に対する自己筋芽細胞パッチ移植によってミトコンドリア機能や冠血流予備能が改善を認めた症例. 日本心臓病学会学術集会(Web). 2023. 71st
三宅啓介, 中村隆, 藤村博信, 新谷隆, 澁谷卓, 宮川繁. 包括的高度慢性下肢虚血(CLTI)に対する治療-Global vascular guidelineを踏まえて- 透析CLTI患者に対するバイパスにおけるGlobal Limb Anatomic Staging Systemの重要性. 日本外科学会定期学術集会抄録集. 2022. 122回. PD-3
森下優, 中本敬, 赤澤康裕, 岡崇史, 溝手勇, 大谷朋仁, 戸田宏一, 彦惣俊吾, 宮川繁, 坂田泰史. COVID-19に合併した劇症型心筋炎の一例. 日本内分泌学会雑誌. 2022. 97. 5. 1508-1508

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Work history (7)：

2021/07 - 現在 Osaka University Graduate School of Medicine Department of Cardiovascular Surgery Professor
2018/04 - 2021/06 Osaka University
2016/07 - 2018/03 Osaka University
2014/04 - 2016/06 Osaka University
2013/04 - 2014/03 Osaka University Graduate School of Medicine

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