Research field (3)：
Human pathology
, Experimental pathology
, Tumor biology
Research keywords (10)：
patient-derived xenograft
, cancer stem cell
, PD-L1
, Y box binding protein
, lung cancer
, 酵素抗原法
, 形質細胞
, Helicobacter pylori
, 標識リガンド
, 標識抗原
Research theme for competitive and other funds (9)：
2021 - 2024 Analysis of role of YB1 in PD-L1 expression to develpe immune check point inhibitor therapy
2018 - 2022 Targeting ceramide synthase 6–dependent metastasis-prone phenotype in lung cancer cells
2018 - 2021 Applicaton of enzyme-labled antigen method for formalin-fixed paraffin-embedded tissue section
2015 - 2017 Detection of specific antibody-producing cells with the enzyme-labeled antigen method in paraffin sections
2013 - 2016 Biological implication and significance of microRNA in inflammatory tumorigenesis - histopathological analysis
2012 - 2014 Analysis of the autoantibodies produced in the diseased synovial tissue in rheumatoid arthritis: The application of the enzyme-labeled antigen method
2010 - 2012 Biological implication of microRNAs in tumorigenesis, tumor development, and progression ? analysis with in situ hybridization using histopathological sections
2009 - 2010 Identifying antigens against antibodies produced in lesional synovium of rheumatoid arthritis and application of the enzyme-labeled antigen method
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Papers (27)：
Atsuko Niimi, Siripan Limsirichaikul, Keiko Kano, Yasuyoshi Mizutani, Toshiyuki Takeuchi, Patinya Sawangsri, Dat Quoc Tran, Yoshiyuki Kawamoto, Motoshi Suzuki. LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration. Cancers. 2023. 15. 10. 2781-2781
Yasuyoshi Mizutani, Kazuya Shiogama, Ken-Ichi Inada, Toshiyuki Takeuchi, Atsuko Niimi, Motoshi Suzuki, Yutaka Tsutsumi. Enzyme-labeled Antigen Method: Factors Influencing the Deterioration of Antigen-binding Activity of Specific Antibodies during Formalin Fixation and Paraffin Embedding. Acta histochemica et cytochemica. 2022. 55. 5. 129-148
Keiko Tamiya-Koizumi, Yurika Otoki, Kiyotaka Nakagawa, Reiji Kannagi, Naoki Mizutani, Motoshi Suzuki, Mamoru Kyogashima, Soichiro Iwaki, Mineyoshi Aoyama, Takashi Murate, et al. Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells. Biochemical and Biophysical Research Communications. 2022
Hanxiao Shi, Atsuko Niimi, Toshiyuki Takeuchi, Kazuya Shiogama, Yasuyoshi Mizutani, Taisuke Kajino, Kenichi Inada, Tetsunari Hase, Takahiro Hatta, Hirofumi Shibata, et al. CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. Cancer science. 2021. 112. 7. 2770-2780
Motoshi Suzuki, Ke Cao, Seiichi Kato, Naoki Mizutani, Kouji Tanaka, Chinatsu Arima, Mei Chee Tai, Norie Nakatani, Kiyoshi Yanagisawa, Toshiyuki Takeuchi, et al. CERS6 required for cell migration and metastasis in lung cancer. Journal of cellular and molecular medicine. 2020. 24. 20. 11949-11959
2015/10 - Japan Society of Histochemisitry and Cytochemistry Young Investigator Award
2012/08 - International Congress of Histochemistry and Cytochemistry Young Histochemist award Visualization of Plasma Cells Producing Disease-specific Antibodies with the Enzyme-labeled Antigen Method
Association Membership(s) (4)：
THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE JAPANESE CANCER ASSOCIATION
, JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY
, THE JAPANESE SOCIETY OF PATHOLOGY
