Rchr
J-GLOBAL ID：201501020337489890   Update date: Nov. 12, 2024

Yamada Takeshi

ヤマダ タケシ | Yamada Takeshi
Affiliation and department：
Institute of Science Tokyo TIDE center

About Institute of Science Tokyo TIDE center


Job title： Project Junior Associate Professor
Homepage URL  (1)： https://kaken.nii.ac.jp/d/r/80633263.ja.html
Research field  (3)： Synthetic organic chemistry ,  Chemical biology ,  Molecular biochemistry
Research keywords  (5)： Organic Chemistry ,  Nucleic acid chemistry ,  核酸医薬 ,  RNA結合性低分子 ,  Chemical Biology
Research theme for competitive and other funds  (7)：
  • 2022 - 2025 Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
  • 2022 - 2025 Development of ASOs which up-regulate the production of circular RNA
  • 2024 - 2025 最適DDSを用いたヘテロ核酸による治療法構築と薬物動態解析
  • 2019 - 2022 Development of small molecules that spontaneously oligomerize on trinucleotide repeats
  • 2017 - 2020 Synthetic study of functional mismatch binding molecules for selective hydrolysis of expanded repeat RNAs
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Papers (26)：
  • Shuhei Sakurabayashi, Takeshi Yamada, Kazuhiko Nakatani. The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding. Bioorganic & Medicinal Chemistry Letters. 2024. 129985-129985
  • Lu Ni, Takeshi Yamada, Kazuhiko Nakatani. Utility of oligonucleotide in upregulating circular RNA production in a cellular model. Scientific Reports. 2024. 14. 1
  • Takeshi Yamada, Shuhei Sakurabayashi, Noriaki Sugiura, Hitoshi Haneoka, Kazuhiko Nakatani. NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA. Chemical Communications. 2024. 60. 27. 3645-3648
  • Lu Ni, Takeshi Yamada, Kazuhiko Nakatani. Utility of oligonucleotide in upregulating circular RNA production in a cellular model. 2024
  • Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani. A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA. Digital Discovery. 2024. 3. 2. 243-248
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MISC (17)：
  • 櫻林修平, 櫻林修平, 古板恭子, 山田剛史, 藤原敏道, 中谷和彦, 児嶋長次郎, 児嶋長次郎. DNA recognition mechanism of naphthyridine dimer, a CGG repeat-binding drug, analyzed by NMR. Abstracts. Annual Meeting of the NMR Society of Japan. 2022. 61st
  • 櫻林修平, 山田剛史, 中谷和彦. 7位修飾ナフチリジンカルバメートダイマーの合成と結合特性. 日本化学会春季年会講演予稿集(CD-ROM). 2019. 99th
  • 八木勇樹, 山田剛史, 中谷和彦. 配列選択的ピリミジン塩基の酸化を指向した,ナフチリジンカルバメートダイマー誘導体の合成とその評価. 日本化学会春季年会講演予稿集(CD-ROM). 2019. 99th
  • 三木翔太, 三木翔太, 山田剛史, 中谷和彦. RNA切断活性をもつミスマッチ結合性リガンドの開発. 日本化学会春季年会講演予稿集(CD-ROM). 2017. 97th
  • 石井陽大, 正木慶昭, 山田剛史, 岡庭夏己, 永田哲也, 武田伸一, 金森功吏, 大窪章寛, 清尾康志, 関根光雄. 筋ジストロフィー治療を指向した塩基部修飾2′-O-MCE RNAの合成と性質. 日本化学会講演予稿集. 2014. 94th. 3
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Patents (9)：
  • 一本鎖核酸及びその用途
  • Focused library
  • 一本鎖核酸及びその用途
  • Chemical modification of monomers and oligonucleotides using cycloaddition
  • Chemical modifications of monomers and oligonucleotides with click components for conjugation with ligands
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Books (1)：
  • Synthesis and Exon-Skipping Activity of Chemically Modified RNAs. Chemical Biology of Nucleic Acids
    Chemical Biology of Nucleic Acids, Springer 2014 ISBN:9783642544514
Lectures and oral presentations  (67)：
  • アンチセンスオリゴによる環状RNA生合成のアップレギュレーション
    (湘南アイパークサイエンスカフェ 2024)
  • Up-regulating of circular RNA production using CLIP-ON oligonucleotide
    (XXV International Round Table on Nucleosides, Nucleotides and Nucleic Acids 2024)
  • Artificial intelligence leading to a cost-effective screening of small molecules targeting nucleic acids
    (XXV International Round Table on Nucleosides, Nucleotides and Nucleic Acids 2024)
  • NMR determination of the binding mode of naphthyridine carbamate dimer (NCD) to CGG repeat DNA
    (2024)
  • リン酸骨格およびダイナミクスに着目したミスマッチDNA-低分子複合体のNMR解析
    (日本化学会第104春季年会 2024)
ｍore...
Education (3)：
  • 2008 - 2011 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Life Science
  • 2006 - 2008 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Life Science
  • 2006 - Tokyo Institute of Technology School of Bioscience and Biotechnology
Professional career (1)：
  • 博士(理学) (東京工業大学)
Work history (10)：
  • 2023/07 - 現在 Osaka University The Institute of Scientific and Industrial Research
  • 2023/04 - 現在 Tokyo Medical and Dental University Project Junior Associate Professor
  • 2020/01 - 2023/03 Osaka University ISIR Assistant Professor
  • 2015/07 - 2020/01 Osaka University ISIR Specially appointed assistant professor
  • 2014/08 - 2015/06 Osaka University The Institute of Scientific and Industrial Research
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Awards (3)：
  • 2022/03 - Tokyo Institute of Technology Seiichi Tejima Research Award (Invention) 2′-hydroxyl group-modified ribonucleoside derivatives
  • 2013/02 - 財団法人手島工業教育資金団 手島精一記念研究賞博士論文賞 「核酸医薬を指向した新規オリゴリボヌクレオチドの合成と性質」
  • 2010/11 - ISNAC Student Oral Award, The 37th International Symposium on Nucleic Acids Chemistry
Association Membership(s) (3)：
日本核酸医薬学会 ,  THE CHEMICAL SOCIETY OF JAPAN ,  Japan Society of Nucleic Acid Chemistry
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