Ota Akinobu

オオタアキノブ | Ota Akinobu

Affiliation and department：

Research field (3)： Hematology and oncology , Pathobiochemistry , Genomics

Research keywords (6)： Innate Immunity , ゲノム編集 , 多発性骨髄腫 , がん , ゲノム異常 , トランスクリプトーム

Research theme for competitive and other funds (13)：

2023 - 2027 癌・精巣特異的嗅覚受容体を介した癌転移機構の解明と臨床応用
2023 - 2026 PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性
2022 - 2025 癌抑制遺伝子BAP1を標的とした胸膜中皮種新規阻害薬の開発
2022 - 2025 ゲノム編集を利用したKRAS変異骨髄腫に対する新規治療標的薬の探索
2021 - 2024 Establishment of the platform for a drug discovery of multiple myeloma by targeting PBK-related signaling pathway

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Papers (94)：

Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, et al. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell Death Discovery. 2024
Xuan Zhou, Hiroki Iida, Yuqiang Li, Akinobu Ota, Lisheng Zhuo, Reiko Nobuhara, Yuki Terajima, Mitsuru Naiki, A Hari Reddi, Koji Kimata, et al. Neurotropin® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response. Molecular Pain. 2024
Toshinori Hyodo, Eri Asano-Inami, Satoko Ito, Mai Sugiyama, Akihiro Nawa, Md Lutfur Rahman, Muhammad Nazmul Hasan, Yuko Mihara, Vu Quang Lam, Sivasundaram Karnan, et al. Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis. The FEBS Journal. 2023
Sivasundaram Karnan, Akinobu Ota, Hideki Murakami, Md. Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Lam Quang Vu, Ichiro Hanamura, Akihito Inoko, Miho Riku, et al. CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma. Cell Death Discovery. 2023
Maho Onda, Akinobu Ota, Kunihiro Ito, Takayuki Ono, Sivasundaram Karnan, Mikako Kato, Sayuri Kondo, Akifumi Furuhashi, Tomio Hayashi, Yoshitaka Hosokawa, et al. Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma. Cancer medicine. 2023

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MISC (87)：

太田明伸, 太田明伸, カルナンシバスンダラン, 小西裕之, 都築忍, 細川好孝, 風岡宜暁. OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
太田明伸, 太田明伸, 恩田真帆, カルナンシバスンダラン, 加藤三香子, 近藤さゆり, 伊藤邦弘, 風岡宜暁, 細川好孝. VEGFR2およびEGFRシグナルの阻害は,口腔扁平上皮癌細胞の生存を低下させる. 日本生化学会大会(Web). 2023. 96th
小野寺一成, 小野寺一成, 下門大祐, 石原康晴, 太田明伸, IRFANUR Rashid Muhammad, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, et al. 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発. 日本再生医療学会総会(Web). 2023. 22nd
周軒, 飯田博己, 木全弘治, 李玉強, 太田明伸, 牛田享宏. 慢性疼痛によるマウス有痛性瘢痕モデルにおける損傷組織部位へのノイロトロピン直接投与の効果. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3P-374
Shinobu Tsuzuki, Takahiko Yasuda, Masahito Kawazu, Toshihide Ueno, Sivasundaram Karnan, Akinobu Ota, Masashi Sanada, Hirokazu Nagai, Akihiro Tomita, Yoshiyuki Takahashi, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. CANCER SCIENCE. 2022. 113. 1236-1236

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Patents (4)：

Books (9)：

ゲノム編集技術 ~実験上のポイント/産業利用に向けた研究開発動向と安全性周知
2023 ISBN:9784865022421
Toxicological Risk Assessment and Multi-System Health Impacts from Exposure
2021 ISBN:9780323853583
CRISPR-Casシステムを用いたゲノム編集と骨髄腫の新たな悪性化因子の同定
Precision Medicine 2021
CRISPR-Cas-mediated genome editing:Novel technology to clarify molecular mechanism contributing to malignant phenotype of multiple myeloma
2020
Role of PDZ binding kinase in tumorigenesis of multiple myeloma
2019

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Education (2)：

2006 - 2010 Sapporo Medical University Graduate School of Medicine
1998 - 2002 Nagoya University Medical faculty Health Sciences

Professional career (1)：

医学博士 (札幌医科大学大学院医学研究科)

Work history (6)：

2023/04 - 現在 Aichi Medical University
2023/04 - 現在 Kinjo Gakuin University College of Human Life and Environment Department of Food and Nutritional Environment Professor
2014/04 - 2023/03 Aichi Medical University School of Medicine Department of Biochemistry Associate Professor
2020/08 - 2021/01 University of Washington Department of Immunology Visiting Assistant Professor
2011/01 - 2013/03 Aichi Medical University School of Medicine Department of Biochemistry Assistant Professor

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Awards (1)：

2018/05 - 日本骨髄腫学会平成30年度日本骨髄腫学会奨励賞

Association Membership(s) (4)：

Japanese Society of Myeloma , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF HEMATOLOGY

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