Research theme for competitive and other funds (6):
2022 - 2026 ALS原因因子FUSの細胞外分泌分子機構の解明
2018 - 2021 FUSR495X変異体による結合RNAを介したALS発症分子機構の解明
2015 - 2018 Identification of ALS linked FUS mutant induced pathological mechanism by genome-wide gene expression analyses
2008 - 2009 FE65による細胞内情報伝達機構の解明
2005 - 2006 APP細胞内領域断片のリン酸化による細胞内情報伝達経路の制御機構解明
2004 - 2006 Analysis of intracellular of APP metabolism and exploration of novel targets of drug suppressing Aβ generation
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Papers (44):
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, et al. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. 2023. 123. 63-74
Tadashi Nakaya. A specific gene-splicing alteration in the SNRNP70 gene as a hallmark of an ALS subtype. Gene. 2022. 818. 146203-146203
Daiki Kawahara, Toshiharu Suzuki, Tadashi Nakaya. Cytoplasmic granule formation by FUS-R495X is attributable to arginine methylation in all Gly-rich, RGG1 and RGG2 domains. Genes to Cells. 2021. 26. 3. 190-197