Rchr
J-GLOBAL ID:201501049907265832   Update date: Feb. 03, 2023

Nakaya Tadashi

ナカヤ タダシ | Nakaya Tadashi
Affiliation and department:
Job title: 講師
Homepage URL  (1): https://kaken.nii.ac.jp/d/r/50374559.ja.html
Research field  (1): Neuroscience - general
Research keywords  (21): RNA ,  FUS ,  ALS ,  アルツハイマー病 ,  APP ,  FE65 ,  リン酸化 ,  細胞死 ,  DNA損傷 ,  核内移行 ,  細胞内情報伝達機構 ,  ストレス応答 ,  AICD ,  βアミロイド ,  X11L ,  神経変性疾患 ,  セクリターゼ ,  神経変性 ,  神経 ,  タンパク質相互作用 ,  認知症
Research theme for competitive and other funds  (6):
  • 2022 - 2026 ALS原因因子FUSの細胞外分泌分子機構の解明
  • 2018 - 2021 FUSR495X変異体による結合RNAを介したALS発症分子機構の解明
  • 2015 - 2018 Identification of ALS linked FUS mutant induced pathological mechanism by genome-wide gene expression analyses
  • 2008 - 2009 FE65による細胞内情報伝達機構の解明
  • 2005 - 2006 APP細胞内領域断片のリン酸化による細胞内情報伝達経路の制御機構解明
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Papers (44):
  • Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, et al. Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging. 2023. 123. 63-74
  • Tadashi Nakaya. A specific gene-splicing alteration in the SNRNP70 gene as a hallmark of an ALS subtype. Gene. 2022. 818. 146203-146203
  • Daiki Kawahara, Toshiharu Suzuki, Tadashi Nakaya. Cytoplasmic granule formation by FUS-R495X is attributable to arginine methylation in all Gly-rich, RGG1 and RGG2 domains. Genes to Cells. 2021. 26. 3. 190-197
  • Tadashi Nakaya. Dissection of FUS domains involved in regulation of SnRNP70 gene expression. FEBS Letters. 2020. 594. 21. 3518-3529
  • Saori Hata, Anqi Hu, Yi Piao, Tadashi Nakaya, Hidenori Taru, Maho Morishima-Kawashima, Shigeo Murayama, Masaki Nishimura, Toshiharu Suzuki. Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels. Human molecular genetics. 2020. 29. 3. 382-393
more...
MISC (34):
Professional career (1):
  • 博士(薬学) (東京大学)
Work history (2):
  • 2020/04 - 現在 International University of Health and Welfare
  • 2013/10 - 2020/03 Hokkaido University
Association Membership(s) (2):
THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE RNA SOCIETY OF JAPAN
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